DE69119785T2 - Zweiphasensystem zur herstellung und präsentation von fremdantigenen in hybriden lebendimpfstoffen - Google Patents

Zweiphasensystem zur herstellung und präsentation von fremdantigenen in hybriden lebendimpfstoffen

Info

Publication number
DE69119785T2
DE69119785T2 DE69119785T DE69119785T DE69119785T2 DE 69119785 T2 DE69119785 T2 DE 69119785T2 DE 69119785 T DE69119785 T DE 69119785T DE 69119785 T DE69119785 T DE 69119785T DE 69119785 T2 DE69119785 T2 DE 69119785T2
Authority
DE
Germany
Prior art keywords
live vaccine
additional antigen
subpopulation
dantigens
presentation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69119785T
Other languages
English (en)
Other versions
DE69119785D1 (de
Inventor
Thomas Meyer
Johannes Pohlner
Frank Reuss
Zhengxin Yan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Priority to DE69119785T priority Critical patent/DE69119785T2/de
Application granted granted Critical
Publication of DE69119785D1 publication Critical patent/DE69119785D1/de
Publication of DE69119785T2 publication Critical patent/DE69119785T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/107—Vibrio
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69119785T 1990-12-20 1991-12-20 Zweiphasensystem zur herstellung und präsentation von fremdantigenen in hybriden lebendimpfstoffen Expired - Fee Related DE69119785T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE69119785T DE69119785T2 (de) 1990-12-20 1991-12-20 Zweiphasensystem zur herstellung und präsentation von fremdantigenen in hybriden lebendimpfstoffen

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4041045A DE4041045A1 (de) 1990-12-20 1990-12-20 Zweiphasen-systeme fuer die produktion und praesentation von fremdantigen in hybriden lebendimpfstoffen
DE69119785T DE69119785T2 (de) 1990-12-20 1991-12-20 Zweiphasensystem zur herstellung und präsentation von fremdantigenen in hybriden lebendimpfstoffen
PCT/EP1991/002478 WO1992011027A1 (en) 1990-12-20 1991-12-20 Two-phase system for the production and presentation of foreign antigens in hybrid live vaccines

Publications (2)

Publication Number Publication Date
DE69119785D1 DE69119785D1 (de) 1996-06-27
DE69119785T2 true DE69119785T2 (de) 1996-12-19

Family

ID=6420942

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4041045A Ceased DE4041045A1 (de) 1990-12-20 1990-12-20 Zweiphasen-systeme fuer die produktion und praesentation von fremdantigen in hybriden lebendimpfstoffen
DE69119785T Expired - Fee Related DE69119785T2 (de) 1990-12-20 1991-12-20 Zweiphasensystem zur herstellung und präsentation von fremdantigenen in hybriden lebendimpfstoffen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE4041045A Ceased DE4041045A1 (de) 1990-12-20 1990-12-20 Zweiphasen-systeme fuer die produktion und praesentation von fremdantigen in hybriden lebendimpfstoffen

Country Status (9)

Country Link
US (1) US6255097B1 (de)
EP (1) EP0565548B1 (de)
JP (1) JPH06504434A (de)
AT (1) ATE138269T1 (de)
DE (2) DE4041045A1 (de)
DK (1) DK0565548T3 (de)
ES (1) ES2087512T3 (de)
GR (1) GR3020495T3 (de)
WO (1) WO1992011027A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0835928A1 (de) * 1996-10-11 1998-04-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin Helicobacter Pylori Lebendimpfstoff
US6797275B1 (en) * 1998-12-04 2004-09-28 The United States Of America As Represented By The Department Of Health And Human Services Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine
US7041296B1 (en) * 1999-11-12 2006-05-09 The United States Of America As Represented By The Department Of Health And Human Services Methods of treating inflammatory bowel disease using cholera toxin B subunit

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337314A (en) * 1979-05-23 1982-06-29 Research Corporation Genetically attenuated bacterial vaccines with multiple mutations of the same phenotype
US4632830A (en) * 1981-07-31 1986-12-30 The United States Of America As Represented By The Secretary Of The Army Oral vaccine for immunization against enteric disease
GB8314645D0 (en) * 1983-05-26 1983-06-29 Wellcome Found Bivalent vaccines
JPS6363381A (ja) * 1986-09-04 1988-03-19 Kokuritsu Yobou Eisei Kenkyusho 組換えワクチニアウイルス
DE4344350C2 (de) * 1993-12-23 1995-09-21 Max Planck Gesellschaft Bakterien zur Herstellung stabiler Fusionsproteine und Verfahren zu deren Nachweis

Also Published As

Publication number Publication date
ATE138269T1 (de) 1996-06-15
DE4041045A1 (de) 1992-07-02
DK0565548T3 (da) 1996-06-17
JPH06504434A (ja) 1994-05-26
WO1992011027A1 (en) 1992-07-09
EP0565548A1 (de) 1993-10-20
DE69119785D1 (de) 1996-06-27
ES2087512T3 (es) 1996-07-16
GR3020495T3 (en) 1996-10-31
EP0565548B1 (de) 1996-05-22
US6255097B1 (en) 2001-07-03

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENS

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee