DE69110807T2 - Verfahren zur herstellung von equimolaren salzen von asparaginsäure und magnesium, magnesiumaspartatsalz nach diesem verfahren und ihre verwendung. - Google Patents
Verfahren zur herstellung von equimolaren salzen von asparaginsäure und magnesium, magnesiumaspartatsalz nach diesem verfahren und ihre verwendung.Info
- Publication number
- DE69110807T2 DE69110807T2 DE69110807T DE69110807T DE69110807T2 DE 69110807 T2 DE69110807 T2 DE 69110807T2 DE 69110807 T DE69110807 T DE 69110807T DE 69110807 T DE69110807 T DE 69110807T DE 69110807 T2 DE69110807 T2 DE 69110807T2
- Authority
- DE
- Germany
- Prior art keywords
- magnesium
- production
- asparagic acid
- aspartate salt
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 title 1
- CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical class OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 title 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical class [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title 1
- 229960005261 aspartic acid Drugs 0.000 title 1
- 239000011777 magnesium Chemical class 0.000 title 1
- 229910052749 magnesium Inorganic materials 0.000 title 1
- 229940091250 magnesium supplement Drugs 0.000 title 1
- RXMQCXCANMAVIO-CEOVSRFSSA-L magnesium;(2s)-2-amino-4-hydroxy-4-oxobutanoate Chemical class [H+].[H+].[Mg+2].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O RXMQCXCANMAVIO-CEOVSRFSSA-L 0.000 title 1
- 239000002184 metal Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9004353A FR2660653B1 (fr) | 1990-04-05 | 1990-04-05 | Sels equimolaires d'acide alpha-amine dicarboxylique et de metal divalent, leur procede de preparation et leur application pour l'obtention de compositions pharmaceutiques. |
| PCT/FR1991/000284 WO1991015463A1 (fr) | 1990-04-05 | 1991-04-05 | PROCEDE DE PREPARATION DE SELS EQUIMOLAIRES D'ACIDE α-AMINE DICARBOXYLIQUE ET DE METAL DIVALENT, SEL D'ASPARTATE DE MAGNESIUM OBTENU PAR LEDIT PROCEDE ET SES APPLICATIONS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69110807D1 DE69110807D1 (de) | 1995-08-03 |
| DE69110807T2 true DE69110807T2 (de) | 1995-12-07 |
Family
ID=9395465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69110807T Expired - Fee Related DE69110807T2 (de) | 1990-04-05 | 1991-04-05 | Verfahren zur herstellung von equimolaren salzen von asparaginsäure und magnesium, magnesiumaspartatsalz nach diesem verfahren und ihre verwendung. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0476120B1 (de) |
| AT (1) | ATE124387T1 (de) |
| AU (1) | AU7652491A (de) |
| DE (1) | DE69110807T2 (de) |
| ES (1) | ES2077225T3 (de) |
| FR (1) | FR2660653B1 (de) |
| WO (1) | WO1991015463A1 (de) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE357754C (de) * | 1919-08-08 | 1922-08-31 | Farbenfab Vorm Bayer F & Co | Verfahren zur Darstellung von Doppelverbindungen aus aliphatischen Aminodicarbonsaeuren |
| ES253183A1 (es) * | 1959-11-05 | 1960-06-01 | M Lab | Procedimiento de obtenciën de bromohidrato de glutamato de magnesio |
| GB910321A (en) * | 1960-02-25 | 1962-11-14 | Olivier Paul Gaudin | Improvements in and relating to a process for preparing ferrous salts of aspartic acid and medicines containing these salts |
| US3836668A (en) * | 1960-12-27 | 1974-09-17 | Ferrer Labor | Therapeutic composition and method of treating patients therewith |
| GB1283810A (en) * | 1970-12-30 | 1972-08-02 | Verla Pharm | Magnesium aspartate hydrohalides |
| US4137326A (en) * | 1975-04-11 | 1979-01-30 | Verla-Pharm Arzneimittelfabrik, Apotheker H.J.V. Ehrlich | Use of magnesium monospartate hydrochloride complex |
| DE3238118A1 (de) * | 1982-10-14 | 1984-04-19 | Verla-Pharm, Arzneimittelfabrik Apotheker H.J. v. Ehrlich GmbH & Co KG, 8132 Tutzing | Verfahren zur herstellung von komplexverbindungen aus aminodicarbonsaeuren, zweiwertigen metallionen und halogenidionen |
-
1990
- 1990-04-05 FR FR9004353A patent/FR2660653B1/fr not_active Expired - Lifetime
-
1991
- 1991-04-05 ES ES91907714T patent/ES2077225T3/es not_active Expired - Lifetime
- 1991-04-05 WO PCT/FR1991/000284 patent/WO1991015463A1/fr active IP Right Grant
- 1991-04-05 AU AU76524/91A patent/AU7652491A/en not_active Abandoned
- 1991-04-05 EP EP91907714A patent/EP0476120B1/de not_active Expired - Lifetime
- 1991-04-05 AT AT91907714T patent/ATE124387T1/de active
- 1991-04-05 DE DE69110807T patent/DE69110807T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU7652491A (en) | 1991-10-30 |
| ATE124387T1 (de) | 1995-07-15 |
| ES2077225T3 (es) | 1995-11-16 |
| DE69110807D1 (de) | 1995-08-03 |
| FR2660653A1 (fr) | 1991-10-11 |
| EP0476120B1 (de) | 1995-06-28 |
| EP0476120A1 (de) | 1992-03-25 |
| FR2660653B1 (fr) | 1994-05-20 |
| WO1991015463A1 (fr) | 1991-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |