DE69025943D1 - Verwendung von Spiperone-derivate zur Immunosuppression - Google Patents
Verwendung von Spiperone-derivate zur ImmunosuppressionInfo
- Publication number
- DE69025943D1 DE69025943D1 DE69025943T DE69025943T DE69025943D1 DE 69025943 D1 DE69025943 D1 DE 69025943D1 DE 69025943 T DE69025943 T DE 69025943T DE 69025943 T DE69025943 T DE 69025943T DE 69025943 D1 DE69025943 D1 DE 69025943D1
- Authority
- DE
- Germany
- Prior art keywords
- immunosuppression
- composition
- spiperone
- mucosal
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Birds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39652389A | 1989-08-21 | 1989-08-21 | |
US49474490A | 1990-03-16 | 1990-03-16 | |
PCT/US1990/004637 WO1991002527A1 (en) | 1989-08-21 | 1990-08-15 | Method and composition for the treatment of cutaneous, ocular, and mucosal hypersensitivity, inflammation, and hyperproliferative conditions using topical preparations of serotonin antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69025943D1 true DE69025943D1 (de) | 1996-04-18 |
DE69025943T2 DE69025943T2 (de) | 1996-09-19 |
Family
ID=27015537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69025943T Expired - Fee Related DE69025943T2 (de) | 1989-08-21 | 1990-08-15 | Verwendung von Spiperone-derivate zur Immunosuppression |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0489108B1 (de) |
JP (1) | JPH05502217A (de) |
AT (1) | ATE135216T1 (de) |
CA (1) | CA2065375A1 (de) |
DE (1) | DE69025943T2 (de) |
IE (1) | IE903012A1 (de) |
NZ (1) | NZ234957A (de) |
PT (1) | PT95058A (de) |
WO (1) | WO1991002527A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5703088A (en) * | 1989-08-21 | 1997-12-30 | Beth Israel Deaconess Medical Center, Inc. | Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses |
US5574041A (en) * | 1990-03-16 | 1996-11-12 | Beth Israel Hospital Association | Use of spiperone derivatives as immunosuppressant agents |
WO1991013622A1 (en) * | 1990-03-16 | 1991-09-19 | Beth Israel Hospital Association | Use of spiperone as an immunosuppressant and anti-inflammatory agent |
EP0555231A1 (de) * | 1990-09-04 | 1993-08-18 | Miles Inc. | Regulierung der neoplastischen zellproliferation durch einen neunen 5h1a-rezeptor |
IT1249678B (it) * | 1991-07-12 | 1995-03-09 | Ciro Costagliola | Collirio per il trattamento della ipertensione oculare |
WO1993012789A1 (en) * | 1991-12-27 | 1993-07-08 | Beth Israel Hospital | Use of spiperone or spiperone derivatives as immunosuppressant agents |
US5693645A (en) * | 1992-12-23 | 1997-12-02 | Beth Israel Deaconess Medical Center, Inc. | Use of spiperone or spiperone derivatives as immunosuppressant agents |
ATE241359T1 (de) * | 1993-03-26 | 2003-06-15 | Beth Israel Hospital | Topische und systemische anwendung von buspiron und seinen derivaten zur behandlung von pathologischen zuständen, die mit immunantworten verbunden sind |
US5484788A (en) * | 1993-03-26 | 1996-01-16 | Beth Israel Hospital Association | Buspirone as a systemic immunosuppressant |
US5631017A (en) * | 1993-03-26 | 1997-05-20 | Beth Israel Deaconess Medical Center, Inc. | Topical application of buspirone for treatment of pathological conditions associated with immune responses |
NZ276088A (en) | 1993-11-19 | 1999-07-29 | Janssen Pharmaceutica Nv | [(1,2-benzisoxazol-3-yl)-1-piperidinyl-alkyl-6,7,8,9-tetrahydro-4h- pyrido[1,2-a]-pyrimidin-4-one derivatives (ie risperidone) |
TW592729B (en) * | 1995-04-06 | 2004-06-21 | Janssen Pharmaceutica Nv | Rate-controlled transdermal administration of risperidone |
JPH11503757A (ja) * | 1995-04-18 | 1999-03-30 | イーライ・リリー・アンド・カンパニー | 5−ht▲下7▼レセプターにおいて生理学的および病理学的機能を生じるエルゴリン化合物の使用方法 |
US5637314A (en) * | 1995-06-07 | 1997-06-10 | Beth Israel Deaconess Medical Center, Inc. | Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis |
US6197830B1 (en) | 1995-09-22 | 2001-03-06 | Bruce M. Frome | Method for achieving relief from sympathetically mediated pain |
JP2000502346A (ja) * | 1995-12-21 | 2000-02-29 | イーライ・リリー・アンド・カンパニー | 皮膚炎の処置方法 |
US5880134A (en) * | 1996-03-20 | 1999-03-09 | Eli Lilly And Company | Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor |
US5886003A (en) * | 1996-03-25 | 1999-03-23 | Eli Lilly And Company | Methods of treating or ameliorating the symptoms of venomous bites and stings |
JP2000507544A (ja) * | 1996-03-25 | 2000-06-20 | イーライ・リリー・アンド・カンパニー | 痛みの治療方法 |
FR2758263B1 (fr) * | 1997-01-16 | 1999-12-17 | Oreal | Utilisation d'un antagoniste ou d'un agoniste de serotonine specifiques respectivement du recepteur 5ht2 et 5ht1d dans une composition cosmetique ou dermatologique pour peaux sensibles et composition obtenue |
US6211171B1 (en) | 1998-05-19 | 2001-04-03 | Dalhousie University | Use of antidepressants for local analgesia |
JP2001039875A (ja) * | 1999-07-30 | 2001-02-13 | Soutetsu Cho | 免疫活性化製剤および免疫活性化方法 |
US6979447B2 (en) * | 2001-03-30 | 2005-12-27 | Philadelphia Health And Education Corporation | Immunomodulation and effect on cell processes relating to serotonin family receptors |
EP1534256A4 (de) * | 2002-06-17 | 2007-06-20 | Philadelphia Health & Educatio | Immunmodulation und wirkung auf die zellprozesse in zusammenhang mit rezeptoren der serotonin-familie und der blut-gehirn-schranke |
WO2004010894A2 (en) | 2002-07-30 | 2004-02-05 | Omeros Corporation | Ophthalmologic irrigation solutions and method |
FR2866567A1 (fr) * | 2004-02-20 | 2005-08-26 | Galderma Res & Dev | Utilisation d'un antagoniste du recepteur beta-adrenergique, at1, 5-ht2, 5-ht5 et/ou de la galanine, pour le traitement de la rosacee |
CN1686139B (zh) * | 2005-04-30 | 2012-07-11 | 福建师范大学 | 酮色林在治疗炎性疼痛的新型镇痛药中的应用 |
GB0701170D0 (en) * | 2007-01-22 | 2007-02-28 | Imp Innovations Ltd | Compositions and uses thereof |
BRPI0810621A2 (pt) | 2007-04-13 | 2017-06-06 | Southern Res Inst | métodos de inibição ou redução da angiogênese, do crescimento ou metástase de tumor dependente da mesma e de tratamento de doença ou desordem associada a angiogênese. |
WO2014049071A1 (en) * | 2012-09-26 | 2014-04-03 | Tangent Reprofiling Limited | Modulators of androgen synthesis |
AU2013201465B2 (en) | 2012-10-24 | 2016-03-03 | Rayner Surgical (Ireland) Limited | Stable preservative-free mydriatic and anti-inflammatory solutions for injection |
WO2015101839A1 (en) * | 2014-01-01 | 2015-07-09 | Avi Dascalu | Compositions and methods of treatment for mycosis fungoides |
TWI705812B (zh) | 2014-12-01 | 2020-10-01 | 奥默羅斯公司 | 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液 |
RU2740378C1 (ru) * | 2020-02-11 | 2021-01-13 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) | Лекарственное средство, стимулирующее регенерацию эндотелия легких при хронической обструктивной болезни легких |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2788309A (en) * | 1954-09-03 | 1957-04-09 | Ciba Pharm Prod Inc | Reserpine composition for parenteral administration |
US2854380A (en) * | 1955-09-06 | 1958-09-30 | Upjohn Co | Aqueous therapeutic composition comprising reserpine, propylene glycol and sorbitol |
EP0268309B1 (de) * | 1986-09-22 | 1996-12-11 | Janssen Pharmaceutica N.V. | Serotonin-Antagonisten zur Behandlung von Wunden |
-
1990
- 1990-08-15 AT AT90913638T patent/ATE135216T1/de not_active IP Right Cessation
- 1990-08-15 JP JP2512725A patent/JPH05502217A/ja active Pending
- 1990-08-15 EP EP90913638A patent/EP0489108B1/de not_active Expired - Lifetime
- 1990-08-15 DE DE69025943T patent/DE69025943T2/de not_active Expired - Fee Related
- 1990-08-15 WO PCT/US1990/004637 patent/WO1991002527A1/en active IP Right Grant
- 1990-08-15 CA CA002065375A patent/CA2065375A1/en not_active Abandoned
- 1990-08-17 NZ NZ234957A patent/NZ234957A/en unknown
- 1990-08-20 IE IE301290A patent/IE903012A1/en unknown
- 1990-08-21 PT PT95058A patent/PT95058A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU6347790A (en) | 1991-04-03 |
PT95058A (pt) | 1991-05-22 |
DE69025943T2 (de) | 1996-09-19 |
IE903012A1 (en) | 1991-02-27 |
NZ234957A (en) | 1997-06-24 |
EP0489108A4 (en) | 1992-10-28 |
EP0489108A1 (de) | 1992-06-10 |
WO1991002527A1 (en) | 1991-03-07 |
JPH05502217A (ja) | 1993-04-22 |
CA2065375A1 (en) | 1991-02-22 |
ATE135216T1 (de) | 1996-03-15 |
AU656121B2 (en) | 1995-01-27 |
EP0489108B1 (de) | 1996-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |