DE69019774D1 - Isochinolin-Derivate zur Behandlung des Glaukoms oder der okulären Hypertonie. - Google Patents

Isochinolin-Derivate zur Behandlung des Glaukoms oder der okulären Hypertonie.

Info

Publication number
DE69019774D1
DE69019774D1 DE69019774T DE69019774T DE69019774D1 DE 69019774 D1 DE69019774 D1 DE 69019774D1 DE 69019774 T DE69019774 T DE 69019774T DE 69019774 T DE69019774 T DE 69019774T DE 69019774 D1 DE69019774 D1 DE 69019774D1
Authority
DE
Germany
Prior art keywords
glaucoma
treatment
ocular hypertension
isoquinoline derivatives
isoquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69019774T
Other languages
English (en)
Other versions
DE69019774T2 (de
Inventor
Toyohiro Tadokoro
Kiyoshi Sato
Shigeki Hatakeyama
Shigeo Kawase
Masao Ueno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Seifun Group Inc
Original Assignee
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP7386689A external-priority patent/JPH02255618A/ja
Priority claimed from JP24230389A external-priority patent/JPH03106816A/ja
Application filed by Nisshin Seifun Group Inc filed Critical Nisshin Seifun Group Inc
Publication of DE69019774D1 publication Critical patent/DE69019774D1/de
Application granted granted Critical
Publication of DE69019774T2 publication Critical patent/DE69019774T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE69019774T 1989-03-28 1990-03-24 Isochinolin-Derivate zur Behandlung des Glaukoms oder der okulären Hypertonie. Expired - Fee Related DE69019774T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7386689A JPH02255618A (ja) 1989-03-28 1989-03-28 緑内障治療剤
JP24230389A JPH03106816A (ja) 1989-09-20 1989-09-20 緑内障治療用点眼剤

Publications (2)

Publication Number Publication Date
DE69019774D1 true DE69019774D1 (de) 1995-07-06
DE69019774T2 DE69019774T2 (de) 1995-11-09

Family

ID=26415010

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69019774T Expired - Fee Related DE69019774T2 (de) 1989-03-28 1990-03-24 Isochinolin-Derivate zur Behandlung des Glaukoms oder der okulären Hypertonie.

Country Status (6)

Country Link
US (1) US5061714A (de)
EP (1) EP0389995B1 (de)
CA (1) CA2013167A1 (de)
DE (1) DE69019774T2 (de)
DK (1) DK0389995T3 (de)
ES (1) ES2075082T3 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3141051B2 (ja) * 1992-10-09 2001-03-05 日清製粉株式会社 抗動脈硬化剤
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
CA2125060C (en) * 1993-07-02 1999-03-30 Henry P. Dabrowski Ophthalmic solution for artificial tears
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5895645A (en) * 1995-01-31 1999-04-20 Bausch & Lomb Incorporated Opthalmic solution for artificial tears
US5800807A (en) * 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US7151102B2 (en) 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
AU2003229953A1 (en) 2002-04-30 2003-11-17 Kudos Pharmaceuticals Limited Phthalazinone derivatives
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
US7220422B2 (en) * 2003-05-20 2007-05-22 Allergan, Inc. Methods and compositions for treating eye disorders
GB0419072D0 (en) 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
JP2008517941A (ja) * 2004-10-21 2008-05-29 デューク・ユニバーシティー 眼科用薬剤
CA2503099A1 (en) * 2005-04-18 2006-10-18 Kabushiki Kaisha Yakult Honsha Pharmaceutical compositions containing camptothecins
US7470787B2 (en) 2005-07-11 2008-12-30 Aerie Pharmaceuticals, Inc. Isoquinoline compounds
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
EP2526948A1 (de) 2006-09-20 2012-11-28 Aerie Pharmaceuticals, Inc. RHO-Kinase-Hemmer
UY30639A1 (es) 2006-10-17 2008-05-31 Kudos Pharm Ltd Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
AU2008299721A1 (en) 2007-09-14 2009-03-19 Astrazeneca Ab Phthalazinone derivatives
CN101821242B (zh) 2007-10-17 2013-07-24 库多斯药物有限公司 4-[3-(4-环丙烷羰基-哌嗪-1-羰基)-4-氟-苄基]-2h-酞嗪-1-酮
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
UY31603A1 (es) 2008-01-23 2009-08-31 Derivados de ftalazinona
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
LT2346495T (lt) 2008-10-07 2016-10-10 Astrazeneca Uk Limited Farmacinė kompozicija 514
EP3053913B1 (de) 2009-05-01 2018-03-07 Aerie Pharmaceuticals, Inc. Hemmer mit doppelmechanismus zur behandlung von erkrankungen
TWI499418B (zh) 2009-05-21 2015-09-11 Nerviano Medical Sciences Srl 異喹啉－１（２ｈ）－酮衍生物
US20140275160A1 (en) 2013-03-15 2014-09-18 Aerie Pharmaceuticals, Inc. Combination therapy
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
AU2015414743B2 (en) 2015-11-17 2019-07-18 Alcon Inc. Process for the preparation of kinase inhibitors and intermediates thereof
JP6907319B2 (ja) 2016-08-31 2021-07-21 アエリエ ファーマシューティカルズ インコーポレイテッド 眼科用組成物
EP3609871A4 (de) 2017-03-31 2021-01-06 Aerie Pharmaceuticals, Inc. Aryl-cyclopropyl-amino-isochinolinyl-amidverbindungen
CA3112391A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
WO2023241652A1 (zh) * 2022-06-16 2023-12-21 广州润尔眼科生物科技有限公司 一种药物组合物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4129565A (en) * 1975-07-11 1978-12-12 Nisshin Flour Milling Co., Ltd. Isocarbostyril derivatives
GB1590629A (en) * 1976-09-23 1981-06-03 Cam Gears Ltd Powerassisted gear system
AU518814B2 (en) * 1979-01-30 1981-10-22 Otsuka Pharamaceutical Co. Glaucoma treatment
JPS57212161A (en) * 1981-06-25 1982-12-27 Nisshin Flour Milling Co Ltd Isocarbostyril derivative
JPS59116269A (ja) * 1982-12-24 1984-07-05 Nisshin Flour Milling Co Ltd イソカルボスチリル誘導体
JPS60237070A (ja) * 1984-05-08 1985-11-25 Nisshin Flour Milling Co Ltd 光学活性イソカルボスチリル誘導体の製法
JPS6355512A (ja) * 1986-08-27 1988-03-10 Hitachi Ltd 微小物質撮像装置

Also Published As

Publication number Publication date
DK0389995T3 (da) 1995-07-03
EP0389995A3 (de) 1991-10-30
EP0389995B1 (de) 1995-05-31
ES2075082T3 (es) 1995-10-01
US5061714A (en) 1991-10-29
EP0389995A2 (de) 1990-10-03
DE69019774T2 (de) 1995-11-09
CA2013167A1 (en) 1990-09-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee