DE69017048D1 - Elektrosprühionenquelle für massenspektrometrie. - Google Patents

Elektrosprühionenquelle für massenspektrometrie.

Info

Publication number
DE69017048D1
DE69017048D1 DE69017048T DE69017048T DE69017048D1 DE 69017048 D1 DE69017048 D1 DE 69017048D1 DE 69017048 T DE69017048 T DE 69017048T DE 69017048 T DE69017048 T DE 69017048T DE 69017048 D1 DE69017048 D1 DE 69017048D1
Authority
DE
Germany
Prior art keywords
ions
mass
tube
desolvation
heat transfer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69017048T
Other languages
English (en)
Other versions
DE69017048T2 (de
Inventor
Brian Chait
Viswanatham Katta
Swapan Chowdhury
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockefeller University
Original Assignee
Rockefeller University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rockefeller University filed Critical Rockefeller University
Application granted granted Critical
Publication of DE69017048D1 publication Critical patent/DE69017048D1/de
Publication of DE69017048T2 publication Critical patent/DE69017048T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404—Capillaries used for transferring samples or ions
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/044—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for preventing droplets from entering the analyzer; Desolvation of droplets
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
DE69017048T 1990-01-22 1990-09-19 Elektrosprühionenquelle für massenspektrometrie. Expired - Lifetime DE69017048T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/467,978 US4977320A (en) 1990-01-22 1990-01-22 Electrospray ionization mass spectrometer with new features
PCT/US1990/005339 WO1991011015A1 (en) 1990-01-22 1990-09-19 Electrospray ion source for mass spectrometry

Publications (2)

Publication Number Publication Date
DE69017048D1 true DE69017048D1 (de) 1995-03-23
DE69017048T2 DE69017048T2 (de) 1995-06-14

Family

ID=23857932

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69017048T Expired - Lifetime DE69017048T2 (de) 1990-01-22 1990-09-19 Elektrosprühionenquelle für massenspektrometrie.

Country Status (8)

Country Link
US (1) US4977320A (de)
EP (1) EP0511961B1 (de)
JP (1) JP3020604B2 (de)
AT (1) ATE118650T1 (de)
AU (1) AU636924B2 (de)
CA (1) CA2074266C (de)
DE (1) DE69017048T2 (de)
WO (1) WO1991011015A1 (de)

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US20060277017A1 (en) * 1993-11-04 2006-12-07 Sproch Norman K Method for the characterization of the three-dimensional structure of proteins employing mass spectrometric analysis and computational feedback modeling
US7047171B1 (en) 1995-12-08 2006-05-16 Sproch Norman K Method for the characterization of the three-dimensional structure of proteins employing mass spectrometric analysis and computational feedback modeling
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US5495108A (en) * 1994-07-11 1996-02-27 Hewlett-Packard Company Orthogonal ion sampling for electrospray LC/MS
US5750988A (en) * 1994-07-11 1998-05-12 Hewlett-Packard Company Orthogonal ion sampling for APCI mass spectrometry
US8847157B2 (en) 1995-08-10 2014-09-30 Perkinelmer Health Sciences, Inc. Multipole ion guide ion trap mass spectrometry with MS/MSn analysis
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DE19734460A1 (de) * 1997-08-11 1999-02-18 Gsf Forschungszentrum Umwelt Verfahren und Vorrichtung zum analytischen Nachweis von Spuren
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US6525313B1 (en) * 2000-08-16 2003-02-25 Brucker Daltonics Inc. Method and apparatus for an electrospray needle for use in mass spectrometry
EP1314186A2 (de) * 2000-08-24 2003-05-28 Newton Scientific, Inc. Probeneneinfuhrschnittstelle zur analytischen behandlung einer auf einem substrat aufgebrachten probe
CA2426731A1 (en) * 2000-10-23 2002-06-20 Genetics Institute, Llc. Acid-labile isotope-coded extractant (alice) and its use in quantitative mass spectrometric analysis of protein mixtures
US6905879B2 (en) * 2000-10-23 2005-06-14 Genetics Institute, Inc. Isotope-coded ionization-enhancing reagents (ICIER) for high-throughput protein identification and quantitation using matrix-assisted laser desorption ionization mass spectrometry
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US6806468B2 (en) * 2001-03-01 2004-10-19 Science & Engineering Services, Inc. Capillary ion delivery device and method for mass spectroscopy
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US6683300B2 (en) 2001-09-17 2004-01-27 Science & Engineering Services, Inc. Method and apparatus for mass spectrometry analysis of common analyte solutions
US7105810B2 (en) 2001-12-21 2006-09-12 Cornell Research Foundation, Inc. Electrospray emitter for microfluidic channel
DE10392706B4 (de) * 2002-05-31 2016-09-29 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Schnelle Kombinations-Mehrfachmodus-Ionisierungsquelle für Massenspektrometer
US7095019B1 (en) 2003-05-30 2006-08-22 Chem-Space Associates, Inc. Remote reagent chemical ionization source
US6943347B1 (en) 2002-10-18 2005-09-13 Ross Clark Willoughby Laminated tube for the transport of charged particles contained in a gaseous medium
WO2005001879A2 (en) * 2003-02-14 2005-01-06 Mds Sciex Atmospheric pressure charged particle discriminator for mass spectrometry
US6900431B2 (en) * 2003-03-21 2005-05-31 Predicant Biosciences, Inc. Multiplexed orthogonal time-of-flight mass spectrometer
US7425700B2 (en) 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
CA2470452C (en) * 2003-06-09 2017-10-03 Ionics Mass Spectrometry Group, Inc. Mass spectrometer interface
US7015466B2 (en) 2003-07-24 2006-03-21 Purdue Research Foundation Electrosonic spray ionization method and device for the atmospheric ionization of molecules
US7537807B2 (en) 2003-09-26 2009-05-26 Cornell University Scanned source oriented nanofiber formation
US20050072915A1 (en) * 2003-10-07 2005-04-07 Biospect Inc. Methods and apparatus for self-optimization of electrospray ionization devices
US20050079631A1 (en) * 2003-10-09 2005-04-14 Science & Engineering Services, Inc. Method and apparatus for ionization of a sample at atmospheric pressure using a laser
US20050133712A1 (en) * 2003-12-18 2005-06-23 Predicant Biosciences, Inc. Scan pipelining for sensitivity improvement of orthogonal time-of-flight mass spectrometers
US7005635B2 (en) * 2004-02-05 2006-02-28 Metara, Inc. Nebulizer with plasma source
US6958473B2 (en) 2004-03-25 2005-10-25 Predicant Biosciences, Inc. A-priori biomarker knowledge based mass filtering for enhanced biomarker detection
US7138626B1 (en) 2005-05-05 2006-11-21 Eai Corporation Method and device for non-contact sampling and detection
US7351960B2 (en) * 2005-05-16 2008-04-01 Thermo Finnigan Llc Enhanced ion desolvation for an ion mobility spectrometry device
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KR100816482B1 (ko) * 2006-02-16 2008-03-24 한국표준과학연구원 높은 공간분해능 레이저 광탈착 이온화 이미징 질량분석을 위한 장치
US20090283674A1 (en) * 2006-11-07 2009-11-19 Reinhold Pesch Efficient Atmospheric Pressure Interface for Mass Spectrometers and Method
US20080116370A1 (en) 2006-11-17 2008-05-22 Maurizio Splendore Apparatus and method for a multi-stage ion transfer tube assembly for use with mass spectrometry
US8288719B1 (en) 2006-12-29 2012-10-16 Griffin Analytical Technologies, Llc Analytical instruments, assemblies, and methods
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US7868289B2 (en) * 2007-04-30 2011-01-11 Ionics Mass Spectrometry Group Inc. Mass spectrometer ion guide providing axial field, and method
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US8637810B2 (en) * 2010-06-24 2014-01-28 Shimadzu Corporation Atmospheric pressure ionization mass spectrometer
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US9048079B2 (en) * 2013-02-01 2015-06-02 The Rockefeller University Method and apparatus for improving ion transmission into a mass spectrometer
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CN107706082B (zh) 2016-08-08 2019-11-26 株式会社岛津制作所 用于质谱仪的限流离子引入接口装置
CN106298429B (zh) * 2016-09-20 2018-03-06 中国科学技术大学 一种电喷雾离子源装置
CN117233413A (zh) 2019-08-05 2023-12-15 禧尔公司 用于样品制备、数据生成和蛋白质冠分析的系统和方法

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Also Published As

Publication number Publication date
ATE118650T1 (de) 1995-03-15
JPH05504017A (ja) 1993-06-24
US4977320A (en) 1990-12-11
AU6623490A (en) 1991-08-05
EP0511961A1 (de) 1992-11-11
CA2074266A1 (en) 1991-07-23
AU636924B2 (en) 1993-05-13
DE69017048T2 (de) 1995-06-14
EP0511961A4 (en) 1993-01-27
WO1991011015A1 (en) 1991-07-25
JP3020604B2 (ja) 2000-03-15
CA2074266C (en) 1999-02-02
EP0511961B1 (de) 1995-02-15

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