DE68924462D1 - Derivate von DC-88A. - Google Patents

Derivate von DC-88A.

Info

Publication number
DE68924462D1
DE68924462D1 DE68924462T DE68924462T DE68924462D1 DE 68924462 D1 DE68924462 D1 DE 68924462D1 DE 68924462 T DE68924462 T DE 68924462T DE 68924462 T DE68924462 T DE 68924462T DE 68924462 D1 DE68924462 D1 DE 68924462D1
Authority
DE
Germany
Prior art keywords
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68924462T
Other languages
English (en)
Other versions
DE68924462T2 (de
Inventor
Yutaka Kanda
Tohru Yasuzawa
Hiromitsu Saito
Hiroshi Sano
Eiji Kobayashi
Makoto Morimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of DE68924462D1 publication Critical patent/DE68924462D1/de
Publication of DE68924462T2 publication Critical patent/DE68924462T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE68924462T 1988-10-21 1989-10-23 Derivate von DC-88A. Expired - Fee Related DE68924462T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP26558288 1988-10-21
JP6257289 1989-03-15

Publications (2)

Publication Number Publication Date
DE68924462D1 true DE68924462D1 (de) 1995-11-09
DE68924462T2 DE68924462T2 (de) 1996-05-02

Family

ID=26403620

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68924462T Expired - Fee Related DE68924462T2 (de) 1988-10-21 1989-10-23 Derivate von DC-88A.

Country Status (3)

Country Link
US (1) US5008271A (de)
EP (1) EP0365041B1 (de)
DE (1) DE68924462T2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5248692A (en) * 1990-06-11 1993-09-28 Kyowa Hakko Kogyo Co., Ltd. DC-89 derivatives as anti-tumor agents
US5214065A (en) * 1990-06-11 1993-05-25 Kyowa Hakko Kogyo Co., Ltd. Dc-89 derivatives
JP2612649B2 (ja) * 1990-07-26 1997-05-21 協和醗酵工業株式会社 Ｄｃ−８９誘導体
EP0468400B1 (de) * 1990-07-26 1996-08-14 Kyowa Hakko Kogyo Co., Ltd. DC-89-Derivate als Antitumor-Wirkstoffe
EP0499130A1 (de) * 1991-02-15 1992-08-19 Kyowa Hakko Kogyo Co., Ltd. Derivate der Verbindung DC-89
US5258383A (en) * 1991-06-28 1993-11-02 Kyowa Hakko Kogyo Co., Ltd. DC-89 derivatives
US5843937A (en) * 1996-05-23 1998-12-01 Panorama Research, Inc. DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents
AU754083B2 (en) * 1997-05-22 2002-11-07 Scripps Research Institute, The Analogs of duocarmycin and CC-1065

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169888A (en) * 1977-10-17 1979-10-02 The Upjohn Company Composition of matter and process
US4400518A (en) * 1980-11-18 1983-08-23 The Upjohn Company Composition of matter and process
US4423229A (en) * 1980-11-18 1983-12-27 The Upjohn Company Composition of matter and process
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
US4423228A (en) * 1980-11-18 1983-12-27 The Upjohn Company Process for preparing N-(methyl-sulfonyl)-1,2,8,8a-cyclopropa[c]benzo[1,2-b:4,3-b']dipyrrol-4(5H)-one
US4423230A (en) * 1980-11-18 1983-12-27 The Upjohn Company Preparation of an intermediate for N-(methylsulfonyl)-1,2,8,8a-cyclopropa[c][1,2-b:-4,3-b']dipyrol-4(5H)-one
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
DE3783588T2 (de) * 1986-04-17 1993-06-09 Kyowa Hakko Kogyo Kk Neue verbindungen dc-88a und dc-89a1 und deren herstellungsverfahren.
WO1988004659A2 (en) * 1986-12-19 1988-06-30 The Upjohn Company Novel cc-1065 analogs
EP0318056A3 (de) * 1987-11-27 1990-12-19 Meiji Seika Kaisha Ltd. Antibiotika und Verfahren zu deren Herstellung
JP2562935B2 (ja) * 1988-04-28 1996-12-11 明治製菓株式会社 抗腫瘍性物質ｓｆ２５８２誘導体

Also Published As

Publication number Publication date
DE68924462T2 (de) 1996-05-02
US5008271A (en) 1991-04-16
EP0365041A1 (de) 1990-04-25
EP0365041B1 (de) 1995-10-04

Similar Documents

Publication Publication Date Title
DE68913022D1 (de) Heterozyklische Derivate.
DE68910421D1 (de) DC-88A-Derivate.
ATE70833T1 (de) Piperazinyl-heterocyclische derivate.
DE69033335D1 (de) DC-88A-Derivate
DE3779563D1 (de) Reduzierte derivate von avermectin.
MX9202933A (es) Derivados de tiazolidindiona.
NO893304L (no) Heterocykliske forbindelser.
DE68907527D1 (de) Laser-bohren von bauteilen.
DE68918802D1 (de) Stickstoff enthaltende heterozyklische Derivate.
DE68907324D1 (de) Nassaetzung von ausgehaerteten polyimiden.
ATE112172T1 (de) Targetformer von antitumor-methyltrithioagenzien.
ATE99694T1 (de) Antiparasitaere derivate.
DE68924462D1 (de) Derivate von DC-88A.
DE69006142D1 (de) Substituierte Glutaramidsäuren und Derivate.
DE58907381D1 (de) Ungesättigte Derivate von 2,2,6,6-Tetramethylpiperidin.
DE3876607D1 (de) Optisch getrennte derivate von neuroprotektivem aminopyrrolidin.
DE3583858D1 (de) Derivate von alcoxymethylaether und alcoxymethylester.
ATE83481T1 (de) Fuenfgliedrige heterocyclische derivate von n'substituiertenn,n'-diacylhydrazinen.
DE3869116D1 (de) Spiro(bis)indan-bis-oxyphthalsaeuren und ihre funktionellen derivate.
ATE102624T1 (de) Makrolide derivate.
DE58903514D1 (de) Derivate der 2,3-difluorbenzoesaeure.
DE68901275D1 (de) Spiro(bis)indanbis(carboxyphenylether) und ihre derivate.
DE3889644D1 (de) Pheophorbidderivate.
DE69011268D1 (de) Diflourobenzonitril Derivate.
DE69002136D1 (de) Saccharidderivate von protocatechualdehyd.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee