DE68922489D1 - Verfahren zur herstellung von radioiodiertem pyrimidin. - Google Patents

Verfahren zur herstellung von radioiodiertem pyrimidin.

Info

Publication number
DE68922489D1
DE68922489D1 DE68922489T DE68922489T DE68922489D1 DE 68922489 D1 DE68922489 D1 DE 68922489D1 DE 68922489 T DE68922489 T DE 68922489T DE 68922489 T DE68922489 T DE 68922489T DE 68922489 D1 DE68922489 D1 DE 68922489D1
Authority
DE
Germany
Prior art keywords
nucleotide
pyrimidine
pyrimidine nucleoside
water
nucleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68922489T
Other languages
English (en)
Other versions
DE68922489T2 (de
Inventor
Amin Kassis
Janina Baranowska-Kortylewicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of DE68922489D1 publication Critical patent/DE68922489D1/de
Application granted granted Critical
Publication of DE68922489T2 publication Critical patent/DE68922489T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
DE68922489T 1988-01-29 1989-01-27 Verfahren zur herstellung von radioiodiertem pyrimidin. Expired - Fee Related DE68922489T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/150,133 US4851520A (en) 1988-01-29 1988-01-29 Method of making radioiodinated pyrimidine nucleoside or nucleotide
PCT/US1989/000358 WO1989007106A1 (en) 1988-01-29 1989-01-27 Method of making radioiodinated pyrimidine

Publications (2)

Publication Number Publication Date
DE68922489D1 true DE68922489D1 (de) 1995-06-08
DE68922489T2 DE68922489T2 (de) 1996-02-01

Family

ID=22533247

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68922489T Expired - Fee Related DE68922489T2 (de) 1988-01-29 1989-01-27 Verfahren zur herstellung von radioiodiertem pyrimidin.

Country Status (6)

Country Link
US (1) US4851520A (de)
EP (1) EP0403544B1 (de)
JP (1) JPH0637509B2 (de)
AT (1) ATE122050T1 (de)
DE (1) DE68922489T2 (de)
WO (1) WO1989007106A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0428623A4 (en) * 1988-08-10 1993-12-08 Stephen Leslie Sacks Production of radioiodinated 1--g(b)-d-arabinofuranosyl)-5(e)-(2-iodovinyl)uracil, and uses thereof, and related analogues incorporating alternative halogen radionuclides, the general radiohalogenation precursors, 1-(2,3,5-tri-o-acetyl--g(b)-d-arabinofuranosyl)-5(z and e)-(2-trimethylsilylvinyl)urac
US5077034A (en) * 1990-03-30 1991-12-31 The President And Fellows Of Harvard College Treatment of tumors with 5-radioiodo-2'-deoxyuridine
US5468853A (en) * 1993-12-30 1995-11-21 Board Of Regents University Of Nebraska Synthesis of 5-radiohalo-2'-deoxyuridine
US5574148A (en) * 1995-02-02 1996-11-12 President U Fellows Of Harvard College Rapid synthesis of radiolabeled pyrimidine nucleosides or nucleotides
US5720935A (en) * 1995-06-09 1998-02-24 President & Fellows Of Harvard College Rapid synthesis of radiolabeled pyrimidine nucleosides or nucleotides from stannyl precursors
US5811073A (en) * 1995-06-19 1998-09-22 President And Fellows Of Harvard College Method for radioisotopic detection and localization of inflammation in a host
US7238338B1 (en) 2001-06-22 2007-07-03 Triumf System and method for the large scale labeling of compounds with radiohalogens
US8597613B2 (en) * 2004-07-02 2013-12-03 Iso-Tex Diagnostics, Inc Radiolabeled lymphatic staining agents and methods for making

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2949451A (en) * 1959-04-21 1960-08-16 Hoffmann La Roche Preparation of thymidine and deoxyfluorouridine, and intermediates therefor
US3135787A (en) * 1960-10-22 1964-06-02 Chemische Werke Witten Process for producing pure sodium salts of 5-sulfo-isophthalic acid and 2-sulfoterephthalic acid
US4649039A (en) * 1984-07-03 1987-03-10 E. I. Du Pont De Nemours And Company Radiolabeling of methionine-containing proteins and peptides

Also Published As

Publication number Publication date
EP0403544B1 (de) 1995-05-03
ATE122050T1 (de) 1995-05-15
EP0403544A4 (en) 1991-04-10
JPH0637509B2 (ja) 1994-05-18
WO1989007106A1 (en) 1989-08-10
EP0403544A1 (de) 1990-12-27
US4851520A (en) 1989-07-25
JPH03500540A (ja) 1991-02-07
DE68922489T2 (de) 1996-02-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee