DE68913688T2 - Verfahren zur Herstellung von Leukotrien-Antagonisten. - Google Patents

Verfahren zur Herstellung von Leukotrien-Antagonisten.

Info

Publication number
DE68913688T2
DE68913688T2 DE68913688T DE68913688T DE68913688T2 DE 68913688 T2 DE68913688 T2 DE 68913688T2 DE 68913688 T DE68913688 T DE 68913688T DE 68913688 T DE68913688 T DE 68913688T DE 68913688 T2 DE68913688 T2 DE 68913688T2
Authority
DE
Germany
Prior art keywords
production
leukotriene antagonists
leukotriene
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68913688T
Other languages
English (en)
Other versions
DE68913688D1 (de
Inventor
David L Hugues
James J Bergan
Paul J Reider
Edward J J Grabowski
Joseph S Amato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE68913688D1 publication Critical patent/DE68913688D1/de
Publication of DE68913688T2 publication Critical patent/DE68913688T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10Nitrogen as only ring hetero atom
    • C12P17/12Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
DE68913688T 1988-12-22 1989-12-20 Verfahren zur Herstellung von Leukotrien-Antagonisten. Expired - Lifetime DE68913688T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/288,216 US5070022A (en) 1988-12-22 1988-12-22 Enzymic process for preparing leukotriene antagonists

Publications (2)

Publication Number Publication Date
DE68913688D1 DE68913688D1 (de) 1994-04-14
DE68913688T2 true DE68913688T2 (de) 1994-09-22

Family

ID=23106235

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68913688T Expired - Lifetime DE68913688T2 (de) 1988-12-22 1989-12-20 Verfahren zur Herstellung von Leukotrien-Antagonisten.

Country Status (5)

Country Link
US (1) US5070022A (de)
EP (1) EP0375394B1 (de)
JP (1) JPH02291290A (de)
CA (1) CA2006197A1 (de)
DE (1) DE68913688T2 (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE59889B1 (en) * 1986-02-14 1994-04-20 Merck Frosst Canada Inc 2-substituted quinoline dioic acids
JPS63245694A (ja) * 1986-11-13 1988-10-12 Showa Shell Sekiyu Kk 光学活性含硫カルボン酸およびその対掌体エステルの製法
EP0271287A3 (de) * 1986-12-11 1990-06-13 Merck Frosst Canada Inc. Chinolindicarbonsäuren und ihre Amide

Also Published As

Publication number Publication date
JPH02291290A (ja) 1990-12-03
CA2006197A1 (en) 1990-06-22
DE68913688D1 (de) 1994-04-14
EP0375394A3 (de) 1991-10-23
EP0375394A2 (de) 1990-06-27
US5070022A (en) 1991-12-03
EP0375394B1 (de) 1994-03-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee