DE68900604D1 - Indolon-derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung. - Google Patents

Indolon-derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung.

Info

Publication number
DE68900604D1
DE68900604D1 DE8989402102T DE68900604T DE68900604D1 DE 68900604 D1 DE68900604 D1 DE 68900604D1 DE 8989402102 T DE8989402102 T DE 8989402102T DE 68900604 T DE68900604 T DE 68900604T DE 68900604 D1 DE68900604 D1 DE 68900604D1
Authority
DE
Germany
Prior art keywords
methoxy
naphthyl
alkyl radical
indolon
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989402102T
Other languages
English (en)
Inventor
Philippe Manoury
Jean Binet
Daniel Obitz
Gerard Defosse
Elisabeth Dewitte
Corinne Veronique
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Application granted granted Critical
Publication of DE68900604D1 publication Critical patent/DE68900604D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8989402102T 1988-08-03 1989-07-25 Indolon-derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung. Expired - Fee Related DE68900604D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8810482A FR2635104B1 (fr) 1988-08-03 1988-08-03 Derives d'indolone, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
DE68900604D1 true DE68900604D1 (de) 1992-02-06

Family

ID=9369068

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989402102T Expired - Fee Related DE68900604D1 (de) 1988-08-03 1989-07-25 Indolon-derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung.

Country Status (6)

Country Link
US (1) US5010079A (de)
EP (1) EP0354094B1 (de)
JP (1) JPH0273062A (de)
AT (1) ATE70826T1 (de)
DE (1) DE68900604D1 (de)
FR (1) FR2635104B1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2635105B1 (fr) * 1988-08-03 1991-01-25 Synthelabo Derives de piperazine et leur procede de preparation
GB9008605D0 (en) * 1990-04-17 1990-06-13 Smith Kline French Lab Process
CA2043709C (en) * 1990-06-29 2002-01-22 David W. Smith Antimigraine alkoxypyrimidine derivatives
US5077293A (en) * 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
CA2084531A1 (en) * 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
FR2687401B1 (fr) * 1992-02-18 1994-05-20 Meram Laboratoires Derives de la 1,4-dialkylpiperazine, procedes d'obtention et compositions pharmaceutiques les contenant.
WO1994021619A1 (en) * 1993-03-16 1994-09-29 Pfizer Inc. Naphthalene derivatives
US5618816A (en) * 1995-03-02 1997-04-08 Bristol-Myers Squibb Company Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines
US5776959A (en) * 1995-06-05 1998-07-07 Washington University Anticonvulsant and anxiolytic lactam and thiolactam derivatives
JPH09124643A (ja) * 1995-08-14 1997-05-13 Bristol Myers Squibb Co 抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体
WO1998008816A1 (fr) * 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Derives d'indoxyle et psychotropes
PT1464641E (pt) * 1999-12-30 2008-07-01 Lundbeck & Co As H Derivados de 4-fenil-1-piperazinilo, -piperidinilo e -tetrahidropiridilo como antagonistas da dopamina d4
MXPA06012403A (es) 2004-04-27 2007-01-17 Wyeth Corp Purificacion de moduladores de receptor progesterona.
ATE435204T1 (de) * 2004-05-11 2009-07-15 Egis Gyogyszergyar Nyrt 3-(((4-phenyl)-piperazin-1-yl)-alkyl)-3-alkyl-1 3-dihydro-2h-indol-2-on-derivate und verwandte verbindungen zur behandlung von erkrankungen des zentralnervensystems
HU0400957D0 (en) * 2004-05-11 2004-07-28 Egyt Gyogyszervegyeszeti Gyar Piperazinbe derivatives of dialkyl oxindoles
EP1751106B1 (de) * 2004-05-11 2008-10-29 EGIS Gyógyszergyár Nyrt Piperazinderivate von alkyloxindolen
HUP0400953A3 (en) * 2004-05-11 2008-02-28 Egis Gyogyszergyar Nyilvanosan Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use
WO2009049030A1 (en) * 2007-10-09 2009-04-16 Triton Biopharma, Llc Method to use compositions having antidepressant anxiolytic and other neurological activity and compositions of matter
US20090281114A1 (en) * 2008-05-08 2009-11-12 Fabre-Kramer Pharmaceuticals, Inc. Indolylalkyl derivatives of pyrimidinylpiperazine and metabolites thereof for treatment of anxiety, depression, and sexual dysfunction
HUP0900071A2 (en) * 2009-02-06 2010-10-28 Egis Gyogyszergyar Nyilvanosan Optically active 3-[(phenyl-piperazin-1-yl)alkyl]-3-alkyl-oxindole derivatives influencing the central nervous system and pharmaceutical compositions containing them
WO2015014256A1 (en) 2013-07-29 2015-02-05 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use thereof
WO2016192657A1 (en) 2015-06-03 2016-12-08 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB944443A (de) * 1959-09-25 1900-01-01
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
US3732248A (en) * 1969-12-15 1973-05-08 Pfizer 3-substituted-1-phenyl indolinones
US4883795A (en) * 1988-01-22 1989-11-28 Pfizer Inc. Piperazinyl-heterocyclic compounds

Also Published As

Publication number Publication date
ATE70826T1 (de) 1992-01-15
EP0354094B1 (de) 1991-12-27
FR2635104B1 (fr) 1992-04-30
EP0354094A1 (de) 1990-02-07
FR2635104A1 (fr) 1990-02-09
US5010079A (en) 1991-04-23
JPH0273062A (ja) 1990-03-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee