DE678948C - Contrast media for the visualization of the genitourinary system through X-rays - Google Patents

Contrast media for the visualization of the genitourinary system through X-rays

Info

Publication number
DE678948C
DE678948C DESCH91645D DESC091645D DE678948C DE 678948 C DE678948 C DE 678948C DE SCH91645 D DESCH91645 D DE SCH91645D DE SC091645 D DESC091645 D DE SC091645D DE 678948 C DE678948 C DE 678948C
Authority
DE
Germany
Prior art keywords
visualization
rays
genitourinary system
contrast media
solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DESCH91645D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DESCH91645D priority Critical patent/DE678948C/en
Application granted granted Critical
Publication of DE678948C publication Critical patent/DE678948C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Description

Kontrastmittel für die Sichtbarmachung des Urogenitalsystems durch Röntgenstrahlen Die Röntgendiagnosti k der Krankheiten des Urogenitalsystems hat in den letzten Jahren an Bedeutung gewonnen. Als Kontrastmittel wurden Lösungen anorganischer Jodsalze, z. B. 25 0/0ige Jodlithiumlösungen, verwendet, deren Zuführung auf dem Wege über die Blase mit Hilfe des Katheters erfolgt ist, ein Verfahren, das neben Schmerzhaftigkeit auch noch andere Nachteile aufweist.Contrast media for the visualization of the genitourinary system X-rays The X-ray diagnosis of diseases of the genitourinary system has gained importance in recent years. Solutions were used as contrast media inorganic iodine salts, e.g. B. 25 0/0 iodine lithium solutions are used, their feed a procedure is carried out on the way through the bladder with the help of the catheter, which besides painfulness also has other disadvantages.

Man hat versucht, die Nachteile dieser Methode dadurch zu vermeiden, daß man harnstoffbaltige Natriumjodidlösungen inj izierte. Doch zeigte sich, daß auch bei Verwendung dieses Mittels wie allgemein bei Verwendung anorganischer Jodsalze wenig brauchbare Bilder erhalten werden.Attempts have been made to avoid the disadvantages of this method by that one injected urea-containing sodium iodide solutions. But it turned out that also when using this agent as in general when using inorganic iodine salts few useful images are obtained.

Es ist ferner vorgeschlagen worden, jodierte Pflanzenöle, wie sie in den Präparaten Campiodol, Jodipin, Lipiodol im Handel sind, für die Zwecke der Pyelographie nutzbar zu machen. Aber auch durch keine dieser Verbindungen wurde ein einwandfreier Bilderfolg erzielt. Dazu kommt noch, daß ihre Einverleibung in den Organismus wegen ihrer Wasserunlöslichkeit nur auf retrogradem Wege möglich ist. It has also been suggested to use iodized vegetable oils like them in the preparations Campiodol, Jodipin, Lipiodol are on the market for the purpose of To harness pyelography. But neither was through any of these connections a flawless picture success achieved. In addition, their incorporation into the organism is only possible in a retrograde way because of its insolubility in water is.

Auch andere für die Pyelographie als Röntgenkontrastmittel empfohlene Verbindungen, wie Tetrajodphenolphthalein, a-Monojodhydrin und ß-jodpropionsaures Natrium und andere, kommen wegen ihrer häufig beobachteten toxischen Nebenwirkungen ebenfalls für eine Anwendung nicht in Frage. Others recommended as X-ray contrast media for pyelography Compounds such as tetraiodophenolphthalein, α-monoiodohydrin and ß-iodopropionic acid Sodium, and others, come because of their commonly observed toxic side effects also out of the question for an application.

Es wurde nun gefunden, daßman alle obenerwähnten Nachteile vermeidet und ausgezeichnete kontrastreiche Bilder erzielt, wenn man als Kontrastmittel entweder Lösungen von dibrom-p-acetaininobenzoesauremNatrium oder von 2-oxo-5-jodpyridin-N-essigsaurem Natrium verwendet. It has now been found that all of the disadvantages mentioned above are avoided and excellent high contrast images are obtained when used as a contrast agent either Solutions of sodium dibromo-p-acetaininobenzoic acid or of 2-oxo-5-iodopyridine-N-acetic acid Sodium used.

Verbindungen dieser Art besitzen auf Grund ihrer physiologischen Indifferenz, ihrer großen Wasserlöslichkeit und ihrer Stabilität den besonideren Vorteil, daß sie intravenös in hoher Konzentration dem Körper einverleibt werden können, wobei sich - Bilder ganz hervorragender Qualität erzielen lassen. Compounds of this type have due to their physiological Indifference, their great water solubility and their stability the more special Advantage that they are incorporated into the body intravenously in high concentrations can, whereby - images of very excellent quality can be achieved.

Verwendet man beispielsweise 40 0/0ige Lösungen ~ von 2-oxo-5-jodpyridin-N-essigsaurem Natrium oder 50 obige Lösungen von dibrom-p-acetaminobenzoesaurem Natrium, so läßt sich bereits kurze Zeit nach der Einverleibung das Urogenitalsystem in ausgezeichneten Klarheit auf dem Röntgenschirm darstellen und photographieren. If, for example, 40% solutions of 2-oxo-5-iodopyridine-N-acetic acid are used Sodium or the above solutions of sodium dibromo-p-acetaminobenzoate, so leave The genitourinary system is already in excellent shape just a short time after it has been incorporated Show clarity on the X-ray screen and take photos.

Claims (1)

PATENTANSPRU C11 : Verwendung von dibrom-p-acetaminobenzoesaurem Natrium oder 2-oxo-5-jodpyridin-N-essigsaurem Natrium als Kontrastmittel für die Sichtbarmachung des Urogenitalsystems durch Röntgenstrahlen. PATENT CLAIM C11: Use of dibromo-p-acetaminobenzoic acid Sodium or 2-oxo-5-iodopyridine-N-acetic acid sodium as a contrast agent for the Visualization of the genitourinary system through X-rays.
DESCH91645D 1929-09-26 1929-09-26 Contrast media for the visualization of the genitourinary system through X-rays Expired DE678948C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DESCH91645D DE678948C (en) 1929-09-26 1929-09-26 Contrast media for the visualization of the genitourinary system through X-rays

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DESCH91645D DE678948C (en) 1929-09-26 1929-09-26 Contrast media for the visualization of the genitourinary system through X-rays

Publications (1)

Publication Number Publication Date
DE678948C true DE678948C (en) 1939-07-25

Family

ID=7444699

Family Applications (1)

Application Number Title Priority Date Filing Date
DESCH91645D Expired DE678948C (en) 1929-09-26 1929-09-26 Contrast media for the visualization of the genitourinary system through X-rays

Country Status (1)

Country Link
DE (1) DE678948C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE973275C (en) * 1951-12-01 1960-01-07 F J Collin A G Device for regulating the flow rate of nozzles for open ovens with gas heating or for gas generation, in particular coke ovens

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE973275C (en) * 1951-12-01 1960-01-07 F J Collin A G Device for regulating the flow rate of nozzles for open ovens with gas heating or for gas generation, in particular coke ovens

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