DE671069C - Process for the preparation of weakly alkaline solutions of methylaesculetin - Google Patents

Process for the preparation of weakly alkaline solutions of methylaesculetin

Info

Publication number
DE671069C
DE671069C DEB172586D DEB0172586D DE671069C DE 671069 C DE671069 C DE 671069C DE B172586 D DEB172586 D DE B172586D DE B0172586 D DEB0172586 D DE B0172586D DE 671069 C DE671069 C DE 671069C
Authority
DE
Germany
Prior art keywords
weakly alkaline
preparation
methylaesculetin
alkaline solutions
solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEB172586D
Other languages
German (de)
Inventor
Dr Fritz Johannessohn
Dr Erich Rabald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DEB172586D priority Critical patent/DE671069C/en
Application granted granted Critical
Publication of DE671069C publication Critical patent/DE671069C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Description

Verfahren zur Herstellung schwach alkalischer Lösungen von Methyläsculetin Es wurde gefunden., daß man aus dem iai Wasser praktisch unlöslichen therapeutisch wertvollen Methyläsculetin (3-Methyl-6, 7-di-,o.xycumarin) für Heilzwecke geeignete schwach alkalische Lösungen herstellen kann, wenn man Triäthanalamin Aals Lösungsvermittler verwendet.Process for the preparation of weakly alkaline solutions of methyl esculetin It has been found that practically insoluble water can be treated therapeutically valuable methylesculetin (3-methyl-6, 7-di-, o.xycumarin) suitable for healing purposes Weakly alkaline solutions can be produced if you use triethanalamine as a solubilizer used.

Obwohl es bekannt ist, daß Methyläsculetin, ähnlich wie andere Oxycwmarine, in Alkali löslich ist, war es doch nicht vorausziusehen, da:ß die verhältnismäßig schwache Base T riäthanolamin diese lösende Wirkung zeigt, da es mittels des nicht viel stärker basischen. Natriumcarbonats nicht gelingt, i o,öige klare Methyläscul,etinlösung.en herzustellen, während man mittels Triäthanolamin zu vollkommen klaren 5 ojoigen Methyläscul@etinlös;ungen kommen kann. Es handelt ;sich hier also nicht nur um einen Neutral.isierungseffekt.Although it is known that methylesculetin, similar to other oxycwmarine, is soluble in alkali, it could not be foreseen that it would be proportionate The weak base triethanolamine shows this dissolving effect because it does not much more basic. Sodium carbonate does not succeed in producing clear methyl acetone solution produce, while using triethanolamine to completely clear 5 ojoigen Methylascul @ etine solutions can occur. It's not just one Neutralizing effect.

Man hat zwar auch schon vorgeschlagen,, zur Herstellung stark ialkalischer, Eiweiß nicht koagulierender antiseptischer Lösungen von. Phe:nolen Amine, darunter auch die aus Monochlorhydrin, Dichlorhydrin, Epichlorhydrin und Ammoniak entstehenden Basen, zuzusetzen; hieraus konnte aber nicht entnammen werden, daß es möglich ist, durch Zusatz von Triäthanö@lamin bei Methyläsculetin Löslichkeitserhöhung zu bewirken und auf solche Weise für .therapeutische Verwendungszwecke geeignete; schwach :alkalisch reagierende Lösungen, welche die Koagulation von Eiweiß nicht hintanhalten, herzustellen.It has already been suggested, for the production of strongly alkaline, Protein of non-coagulating antiseptic solutions of. Phe: nolen amines, including also those arising from monochlorohydrin, dichlorohydrin, epichlorohydrin and ammonia Bases to add; but it could not be deduced from this that it is possible to bring about an increase in the solubility of methyl aesculetin by adding Triäthanö @ lamin and in such a way suitable for .therapeutic purposes; weak: alkaline to produce reactive solutions that do not prevent the coagulation of protein.

Beispiel Man gibt zu Methyläsculetin eine 8o,oige wäßrige Triäthanolaminlösuug; man erhält so eine 2%ige- Lösung bezogen auf Methyläsculetin.EXAMPLE An 80% aqueous triethanolamine solution is added to methylesculetin; a 2% solution based on methyl esculetin is thus obtained.

Claims (1)

PATl?NTAXIS1'RUCIi: Verfahren zur Herstellung schwach alkalischer, für Heilzwecke ge"eignie:,er wäßriger Lösungen von Methyläscul.etin, dadurch gekennzeichnet, daß man Triäthanolami,n als Lösungsvermittler zusetzt.PATl? NTAXIS1'RUCIi: Process for the production of weakly alkaline, suitable for healing purposes:, he aqueous solutions of Methyläscul.etin, characterized in, that one adds triethanolami, n as a solubilizer.
DEB172586D 1936-01-19 1936-01-19 Process for the preparation of weakly alkaline solutions of methylaesculetin Expired DE671069C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEB172586D DE671069C (en) 1936-01-19 1936-01-19 Process for the preparation of weakly alkaline solutions of methylaesculetin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB172586D DE671069C (en) 1936-01-19 1936-01-19 Process for the preparation of weakly alkaline solutions of methylaesculetin

Publications (1)

Publication Number Publication Date
DE671069C true DE671069C (en) 1939-01-31

Family

ID=7007054

Family Applications (1)

Application Number Title Priority Date Filing Date
DEB172586D Expired DE671069C (en) 1936-01-19 1936-01-19 Process for the preparation of weakly alkaline solutions of methylaesculetin

Country Status (1)

Country Link
DE (1) DE671069C (en)

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