DE632131C - Process for converting vitamin B into a fat-soluble, easily split form - Google Patents

Process for converting vitamin B into a fat-soluble, easily split form

Info

Publication number
DE632131C
DE632131C DEI50594D DEI0050594D DE632131C DE 632131 C DE632131 C DE 632131C DE I50594 D DEI50594 D DE I50594D DE I0050594 D DEI0050594 D DE I0050594D DE 632131 C DE632131 C DE 632131C
Authority
DE
Germany
Prior art keywords
soluble
vitamin
fat
easily split
split form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEI50594D
Other languages
German (de)
Inventor
Dr Richard Kuhn
Dr Hermann Rudy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IG Farbenindustrie AG
Original Assignee
IG Farbenindustrie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IG Farbenindustrie AG filed Critical IG Farbenindustrie AG
Priority to DEI50594D priority Critical patent/DE632131C/en
Application granted granted Critical
Publication of DE632131C publication Critical patent/DE632131C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)

Description

Verfahren zur Überführung des Vitamins B2 in eine fettlösliche, leicht spaltbare Form Das Vitamin B2 (Lactoflavin) ist in Wasser leicht, in Fetten aber ganz unlöslich. Zur Herstellung einer Lösung, die sowohl lipoidlösliche Vitamine als auch das Vitamin B2 enthalten soll, ist es erforderlich, dieses letztere Vitamin ebenfalls in eine lipoidlösliche, dabei aber leicht spaltbare Form übertuführen. Es wurde gefunden, daß man durch Einwirken von Aceton auf das Vitamin B2 (Lactoflavin) eine lipoidlösliche Acetonverbindung des Vitamins B2 erhält, die schon durch sehr verdünnte Säuren, wie z. B. die Sausäure des Magens, wieder gespalten wird, wobei das wirksame Vitamin in Freiheit gesetzt wird.Method for converting vitamin B2 into a fat-soluble, easily Fissile form Vitamin B2 (lactoflavin) is light in water, but in fats completely insoluble. To prepare a solution that contains both lipoid soluble vitamins as well as containing vitamin B2, it is necessary to have this latter vitamin likewise in a lipoid-soluble, but easily cleavable form. It has been found that the action of acetone on vitamin B2 (lactoflavin) a lipoid-soluble acetone compound of vitamin B2 is obtained, which is already through very dilute acids such as B. the acid of the stomach, is split again, whereby the effective vitamin is set free.

Beispiel i Gewichtsteil kristallisiertes Lactoflavin wird mit iooo Gewichtsteilen trockenem Aceton, das i % Salzsäure enthält, i--Stunden geschüttelt. Man neutralisiert, verdampft den größten Teil des Acetons im Vakuum, verdünnt mit Wasser und schüttelt mit Chloroform aus. Das chloröformlösliche Acetonlactoflavin wird nach Entfernung des Chloroforms aus wäßrigem Alkohol umkristallisiert.Example i part by weight of crystallized lactoflavin is with iooo Parts by weight of dry acetone containing 1% hydrochloric acid, shaken for 1 hour. Neutralize, evaporate most of the acetone in vacuo, dilute with Water and shake out with chloroform. The chloroform-soluble acetone lactoflavin is recrystallized from aqueous alcohol after removal of the chloroform.

Claims (1)

PATENTANSPRUCH: Verfahren zur Überführung des Vitamins B2 .(Lactoflavin) in eine fettlösliche, leicht spaltbare Form, darin bestehend, daß man das Vitamin B2 durch Einwirkung von Aceton zu seiner Acetonverbindung umsetzt.PATENT CLAIM: Process for transferring vitamin B2. (Lactoflavin) into a fat-soluble, easily split form, consisting in getting the vitamin B2 is converted to its acetone compound by the action of acetone.
DEI50594D 1934-09-20 1934-09-20 Process for converting vitamin B into a fat-soluble, easily split form Expired DE632131C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEI50594D DE632131C (en) 1934-09-20 1934-09-20 Process for converting vitamin B into a fat-soluble, easily split form

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEI50594D DE632131C (en) 1934-09-20 1934-09-20 Process for converting vitamin B into a fat-soluble, easily split form

Publications (1)

Publication Number Publication Date
DE632131C true DE632131C (en) 1936-07-03

Family

ID=7192865

Family Applications (1)

Application Number Title Priority Date Filing Date
DEI50594D Expired DE632131C (en) 1934-09-20 1934-09-20 Process for converting vitamin B into a fat-soluble, easily split form

Country Status (1)

Country Link
DE (1) DE632131C (en)

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