DE60331781D1 - Verwendung von synergistischen lytischen enzymen aus bakteriophagen zur vorbeugung und behandlung bakterieller infektionen - Google Patents
Verwendung von synergistischen lytischen enzymen aus bakteriophagen zur vorbeugung und behandlung bakterieller infektionenInfo
- Publication number
- DE60331781D1 DE60331781D1 DE60331781T DE60331781T DE60331781D1 DE 60331781 D1 DE60331781 D1 DE 60331781D1 DE 60331781 T DE60331781 T DE 60331781T DE 60331781 T DE60331781 T DE 60331781T DE 60331781 D1 DE60331781 D1 DE 60331781D1
- Authority
- DE
- Germany
- Prior art keywords
- enzymes
- bacterial infections
- bacteriophages
- prevention
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 5
- 108090000790 Enzymes Proteins 0.000 title abstract 5
- 208000035143 Bacterial infection Diseases 0.000 title abstract 3
- 208000022362 bacterial infectious disease Diseases 0.000 title abstract 3
- 230000002101 lytic effect Effects 0.000 title abstract 2
- 241001515965 unidentified phage Species 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title 1
- 230000002195 synergetic effect Effects 0.000 title 1
- 229930182555 Penicillin Natural products 0.000 abstract 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 2
- 229940049954 penicillin Drugs 0.000 abstract 2
- 101100203377 Bacillus subtilis (strain 168) slp gene Proteins 0.000 abstract 1
- 101100221834 Caenorhabditis elegans cpl-1 gene Proteins 0.000 abstract 1
- 101100242529 Drosophila melanogaster Pal2 gene Proteins 0.000 abstract 1
- 101150012565 LRIT1 gene Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 abstract 1
- 101100477497 Mus musculus Shcbp1 gene Proteins 0.000 abstract 1
- 108010013639 Peptidoglycan Proteins 0.000 abstract 1
- 241000193998 Streptococcus pneumoniae Species 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 210000002421 cell wall Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000000249 desinfective effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 101150077062 pal gene Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011012 sanitization Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/23—Solid substances, e.g. granules, powders, blocks, tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01017—Lysozyme (3.2.1.17)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01028—N-Acetylmuramoyl-L-alanine amidase (3.5.1.28)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43607702P | 2002-12-23 | 2002-12-23 | |
| PCT/US2003/041229 WO2004058182A2 (en) | 2002-12-23 | 2003-12-23 | Use of synergistic bacteriophage lytic enzymes for prevention and treatment of bacterial infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60331781D1 true DE60331781D1 (de) | 2010-04-29 |
Family
ID=32682335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60331781T Expired - Lifetime DE60331781D1 (de) | 2002-12-23 | 2003-12-23 | Verwendung von synergistischen lytischen enzymen aus bakteriophagen zur vorbeugung und behandlung bakterieller infektionen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20060159671A1 (de) |
| EP (1) | EP1585478B1 (de) |
| AT (1) | ATE460920T1 (de) |
| AU (1) | AU2003303338C1 (de) |
| CA (1) | CA2511492A1 (de) |
| DE (1) | DE60331781D1 (de) |
| WO (1) | WO2004058182A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006063176A2 (en) * | 2004-12-06 | 2006-06-15 | The Government Of The Usa As Representedtd By The Secretary Of The Dept Of Health And Human Services | Inhibition of biofilm formation using bacteriophage |
| CA2609357A1 (en) * | 2005-05-26 | 2006-11-30 | Gangagen Life Sciences Inc. | Bacterial management in animal holding systems |
| US20110295090A1 (en) | 2008-12-04 | 2011-12-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, and methods including implantable devices with anti-microbial properties |
| DK2764093T3 (en) | 2011-10-05 | 2018-07-30 | Univ Rockefeller | DIMER BACTERYPHAGE LYSINES |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957686A (en) * | 1990-02-06 | 1990-09-18 | Norris Alan H | Use of bacteriophages to inhibit dental caries |
| AU699322B2 (en) * | 1994-04-05 | 1998-12-03 | Exponential Biotherapies, Inc. | Antibacterial therapy with genotypically modified bacteriophage |
| US6254866B1 (en) * | 1997-10-31 | 2001-07-03 | New Horizons Diagnostics Corporation | Use of phage associated lytic enzymes for treating bacterial infections of the digestive tract |
| US6056954A (en) * | 1997-10-31 | 2000-05-02 | New Horizons Diagnostics Corp | Use of bacterial phage associated lysing enzymers for the prophylactic and therapeutic treatment of various illnesses |
| US6277399B1 (en) * | 1997-10-31 | 2001-08-21 | New Horizon Diagnostics Corporation | Composition incorporating bacterial phage associated lysing enzymes for treating dermatological infections |
| US6264945B1 (en) * | 1997-10-31 | 2001-07-24 | Vincent A Fischetti | Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections |
| EP1250050B1 (de) * | 2000-01-11 | 2004-10-27 | Intralytix Inc. | Verfahren und vorrichtung zur reinigung mit bakteriophagen |
-
2003
- 2003-12-23 US US10/540,666 patent/US20060159671A1/en not_active Abandoned
- 2003-12-23 AU AU2003303338A patent/AU2003303338C1/en not_active Ceased
- 2003-12-23 DE DE60331781T patent/DE60331781D1/de not_active Expired - Lifetime
- 2003-12-23 WO PCT/US2003/041229 patent/WO2004058182A2/en not_active Application Discontinuation
- 2003-12-23 CA CA002511492A patent/CA2511492A1/en not_active Abandoned
- 2003-12-23 AT AT03808560T patent/ATE460920T1/de not_active IP Right Cessation
- 2003-12-23 EP EP03808560A patent/EP1585478B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20060159671A1 (en) | 2006-07-20 |
| EP1585478A4 (de) | 2007-09-26 |
| AU2003303338C1 (en) | 2009-11-26 |
| CA2511492A1 (en) | 2004-07-15 |
| AU2003303338A1 (en) | 2004-07-22 |
| ATE460920T1 (de) | 2010-04-15 |
| EP1585478A2 (de) | 2005-10-19 |
| AU2003303338B2 (en) | 2009-04-09 |
| WO2004058182A2 (en) | 2004-07-15 |
| EP1585478B1 (de) | 2010-03-17 |
| WO2004058182A3 (en) | 2006-01-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |