DE60331414D1 - AGGRECANASE 1 AND 2 PEPTIDE SUBSTRATES AND METHOD - Google Patents
AGGRECANASE 1 AND 2 PEPTIDE SUBSTRATES AND METHODInfo
- Publication number
- DE60331414D1 DE60331414D1 DE60331414T DE60331414T DE60331414D1 DE 60331414 D1 DE60331414 D1 DE 60331414D1 DE 60331414 T DE60331414 T DE 60331414T DE 60331414 T DE60331414 T DE 60331414T DE 60331414 D1 DE60331414 D1 DE 60331414D1
- Authority
- DE
- Germany
- Prior art keywords
- aggrecanase
- peptide substrates
- metalloproteases
- proteases
- modulate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Detergent Compositions (AREA)
- Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)
Abstract
The present invention describes synthetic peptide substrates of the metalloproteases, aggrecanase-1 and/or -2 suitable for assays of enzyme activity. The invention also describes methods using these peptides to discover pharmaceutical agents that modulate these proteases.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/050,200 US20030166037A1 (en) | 2002-01-16 | 2002-01-16 | Aggrecanase-1 and -2 peptide substrates and methods |
PCT/US2003/001327 WO2003062263A2 (en) | 2002-01-16 | 2003-01-15 | Aggrecanase-1 and -2 peptide substrates and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60331414D1 true DE60331414D1 (en) | 2010-04-08 |
Family
ID=27609064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60331414T Expired - Lifetime DE60331414D1 (en) | 2002-01-16 | 2003-01-15 | AGGRECANASE 1 AND 2 PEPTIDE SUBSTRATES AND METHOD |
Country Status (8)
Country | Link |
---|---|
US (2) | US20030166037A1 (en) |
EP (1) | EP1474509B1 (en) |
AT (1) | ATE458810T1 (en) |
AU (1) | AU2003203028A1 (en) |
CA (1) | CA2473513C (en) |
DE (1) | DE60331414D1 (en) |
ES (1) | ES2339758T3 (en) |
WO (1) | WO2003062263A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20040088059A (en) * | 2002-02-05 | 2004-10-15 | 와이어쓰 | Truncated aggrecanase molecules |
US6933275B2 (en) * | 2002-05-01 | 2005-08-23 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase C peptides for use in withdrawal |
WO2007146802A2 (en) * | 2006-06-09 | 2007-12-21 | University Of Maryland, Baltimore | System and compositions for isolating suppressors of hiv-1 protease |
EP2746402A1 (en) * | 2013-03-12 | 2014-06-25 | Academisch Medisch Centrum | Method of prognosis of Alzheimers disease and substrates for use therein |
JP2020508058A (en) * | 2017-02-22 | 2020-03-19 | ユニヴェルシテ・ドゥ・モントリオール | Novel minor histocompatibility antigens and their use |
JP7369428B2 (en) * | 2019-08-09 | 2023-10-26 | 国立大学法人群馬大学 | Sugar compounds and their uses |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6803188B1 (en) * | 1996-01-31 | 2004-10-12 | The Regents Of The University Of California | Tandem fluorescent protein constructs |
AU8513098A (en) * | 1998-07-24 | 2000-02-14 | Du Pont Pharmaceuticals Company | Assays and peptide substrate for determining aggrecan degrading metallo proteaseactivity |
EP1315490B1 (en) * | 2000-09-06 | 2008-11-12 | Ortho-McNeil Pharmaceutical, Inc. | A method for treating allergies using substituted pyrazoles |
-
2002
- 2002-01-16 US US10/050,200 patent/US20030166037A1/en not_active Abandoned
-
2003
- 2003-01-15 WO PCT/US2003/001327 patent/WO2003062263A2/en not_active Application Discontinuation
- 2003-01-15 DE DE60331414T patent/DE60331414D1/en not_active Expired - Lifetime
- 2003-01-15 EP EP03702145A patent/EP1474509B1/en not_active Expired - Lifetime
- 2003-01-15 AT AT03702145T patent/ATE458810T1/en not_active IP Right Cessation
- 2003-01-15 AU AU2003203028A patent/AU2003203028A1/en not_active Abandoned
- 2003-01-15 ES ES03702145T patent/ES2339758T3/en not_active Expired - Lifetime
- 2003-01-15 CA CA2473513A patent/CA2473513C/en not_active Expired - Fee Related
-
2004
- 2004-12-15 US US11/012,797 patent/US7312045B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1474509A4 (en) | 2005-12-28 |
AU2003203028A1 (en) | 2003-09-02 |
US20050164319A1 (en) | 2005-07-28 |
US20030166037A1 (en) | 2003-09-04 |
EP1474509A2 (en) | 2004-11-10 |
WO2003062263A3 (en) | 2004-01-15 |
ES2339758T3 (en) | 2010-05-25 |
ATE458810T1 (en) | 2010-03-15 |
CA2473513C (en) | 2012-03-20 |
EP1474509B1 (en) | 2010-02-24 |
CA2473513A1 (en) | 2003-07-31 |
US7312045B2 (en) | 2007-12-25 |
WO2003062263A2 (en) | 2003-07-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69101557T2 (en) | ENZYMATIC DETERGENT COMPOSITION AND METHOD FOR STABILIZING THE ENZYME. | |
ATE496123T1 (en) | NUCLEIC ACIDS WHICH CODE FOR TRAM MEMBRANE SERINE PROTEASES, THE ENCODED PROTEINS AND METHODS BASED THEREON | |
TW200745552A (en) | HU-ASP 1 protease substrate and uses thereof | |
DE60127441D1 (en) | dipeptidylpeptidases | |
ATE279203T1 (en) | USE OF SUBSTRATE SUBTRACTION LIBRARIES TO DIFFERENTIATE ENZYME SPECIFICITIES | |
DE69637307D1 (en) | CYSTEIN AND SERINE PROTEASE INHIBITORS DERIVED FROM D-AMINO ACIDS | |
TR199902751T2 (en) | Protease inhibitors. | |
DE69705838D1 (en) | SUBSTRATES AND INHIBITORS OF PROTEOLYTIC ENZYMS | |
IS5905A (en) | Alzheimer's secretion | |
WO2004020458A3 (en) | Assays and compositions for identifying agents that modulate the activity of deubiquitinating agents | |
ATE382148T1 (en) | ANTIBODIES FOR APOPTOSIS MARKERS AND METHODS OF APPLICATION | |
DK1083903T3 (en) | Bridged Indopyrrolocarbazoles | |
EP1032393A4 (en) | Quinoline-containing alpha-ketoamide cysteine and serine protease inhibitors | |
ATE350470T1 (en) | CHIMERIC PROTEINS CLIPABLE BY THROMBIN | |
ATE309264T1 (en) | PEPTIDYL-2-AMINO-1HYDROXYALKANSULPHONIC ACIDS AS CYSTEINE PROTEASE INHIBITORS | |
HK1016495A1 (en) | Phosphorous-containing cysteine and serine protease inhibitors | |
DE60134230D1 (en) | SUBSTRATES AND EVIDENCE ON THE EFFICACY OF BETA-SECRETASE | |
DE60331414D1 (en) | AGGRECANASE 1 AND 2 PEPTIDE SUBSTRATES AND METHOD | |
DE602006017359D1 (en) | SUBSTRATE FOR RPN-11 ENZYME ACTIVITY | |
ATE295737T1 (en) | USE OF ENZYMES OBTAINED FROM CILIATES AS DIGESTIVE MEDICATIONS | |
WO2002093177A3 (en) | Assays for identifying modulators of rhomboid polypeptides | |
MXPA02012030A (en) | Metalloprotease peptide substrates and methods. | |
DE60236996D1 (en) | CULTURAL MEDIUM FOR THE DETECTION OF BACTERIA OF THE GENUS LISTERIA | |
SI1539815T1 (en) | Crystal structure of an angiotensin-converting enzyme (ace) and uses thereof | |
DE60031856D1 (en) | SÄUGERADHÄSIONPROTEASE |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |