AU8513098A - Assays and peptide substrate for determining aggrecan degrading metallo proteaseactivity - Google Patents

Assays and peptide substrate for determining aggrecan degrading metallo proteaseactivity

Info

Publication number
AU8513098A
AU8513098A AU85130/98A AU8513098A AU8513098A AU 8513098 A AU8513098 A AU 8513098A AU 85130/98 A AU85130/98 A AU 85130/98A AU 8513098 A AU8513098 A AU 8513098A AU 8513098 A AU8513098 A AU 8513098A
Authority
AU
Australia
Prior art keywords
proteaseactivity
assays
determining
peptide substrate
metallo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU85130/98A
Inventor
Elizabeth C. Arner
Robert A. Copeland
Gary L. Davis
Jeffrey A. Miller
Michael Pratta
Micky D. Tortorella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Publication of AU8513098A publication Critical patent/AU8513098A/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
AU85130/98A 1998-07-24 1998-07-24 Assays and peptide substrate for determining aggrecan degrading metallo proteaseactivity Abandoned AU8513098A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1998/015436 WO2000005256A1 (en) 1998-07-24 1998-07-24 Assays and peptide substrate for determining aggrecan degrading metallo protease activity

Publications (1)

Publication Number Publication Date
AU8513098A true AU8513098A (en) 2000-02-14

Family

ID=22267553

Family Applications (1)

Application Number Title Priority Date Filing Date
AU85130/98A Abandoned AU8513098A (en) 1998-07-24 1998-07-24 Assays and peptide substrate for determining aggrecan degrading metallo proteaseactivity

Country Status (2)

Country Link
AU (1) AU8513098A (en)
WO (1) WO2000005256A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030166037A1 (en) * 2002-01-16 2003-09-04 Fourie Anne M. Aggrecanase-1 and -2 peptide substrates and methods
PL371525A1 (en) * 2002-01-31 2005-06-27 Wyeth Aggrecanase molecules
DE102004029470A1 (en) * 2004-06-18 2006-01-05 InViTek Gesellschaft für Biotechnik & Biodesign mbH Method for determining aggrecanase activities

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5427954A (en) * 1992-04-29 1995-06-27 Shriner's Hospitals For Crippled Children Compositions and methods for detection and treatment of human osteoarthritis
AUPM666894A0 (en) * 1994-07-07 1994-07-28 University Of Melbourne, The Diagnostic methods and compositions
JP2000503533A (en) * 1996-01-04 2000-03-28 ネーデルランドセ・オルガニザテイエ・フール・テゲパスト―ナトウールベテンシヤツペリーク・オンデルツエク・テイエヌオー Assay method for protease using fluorescent quenching substrate
PT785274E (en) * 1996-01-18 2001-01-31 Aventis Pharma Gmbh ARTIFICIAL RECOMBINANT SUBSTRATE (RAGG 1) AND AGRECANO NATIVE TO STUDY THE PROTEOLITIC ACTIVITY OF 'AGRECANASE' IN CELL CULTURE SYSTEMS

Also Published As

Publication number Publication date
WO2000005256A1 (en) 2000-02-03

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase