DE60327891D1 - Vorrichtung und verfahren zur untersuchung der männlichen fertilität - Google Patents

Vorrichtung und verfahren zur untersuchung der männlichen fertilität

Info

Publication number
DE60327891D1
DE60327891D1 DE60327891T DE60327891T DE60327891D1 DE 60327891 D1 DE60327891 D1 DE 60327891D1 DE 60327891 T DE60327891 T DE 60327891T DE 60327891 T DE60327891 T DE 60327891T DE 60327891 D1 DE60327891 D1 DE 60327891D1
Authority
DE
Germany
Prior art keywords
sperm
sample
microchannel
density
detector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60327891T
Other languages
English (en)
Inventor
Alexander M Aravanis
Jason L Pyle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Advanced Fluidix Laboratories LLC
Original Assignee
Advanced Fluidix Laboratories LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Fluidix Laboratories LLC filed Critical Advanced Fluidix Laboratories LLC
Application granted granted Critical
Publication of DE60327891D1 publication Critical patent/DE60327891D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1027—Determining speed or velocity of a particle
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
DE60327891T 2002-12-09 2003-12-09 Vorrichtung und verfahren zur untersuchung der männlichen fertilität Expired - Lifetime DE60327891D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US43187202P 2002-12-09 2002-12-09
US51179803P 2003-10-16 2003-10-16
US10/705,162 US6929945B2 (en) 2002-12-09 2003-11-06 Male fertility assay method and device
PCT/US2003/039069 WO2004053465A2 (en) 2002-12-09 2003-12-09 Male fertility assay method and device

Publications (1)

Publication Number Publication Date
DE60327891D1 true DE60327891D1 (de) 2009-07-16

Family

ID=32512332

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60327891T Expired - Lifetime DE60327891D1 (de) 2002-12-09 2003-12-09 Vorrichtung und verfahren zur untersuchung der männlichen fertilität

Country Status (9)

Country Link
US (2) US6929945B2 (de)
EP (1) EP1581798B1 (de)
JP (1) JP4529019B2 (de)
KR (1) KR20050085471A (de)
AT (1) ATE433103T1 (de)
AU (1) AU2003297757B2 (de)
CA (1) CA2507031A1 (de)
DE (1) DE60327891D1 (de)
WO (1) WO2004053465A2 (de)

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US20060270021A1 (en) * 2004-06-07 2006-11-30 Shuichi Takayama Integrated microfluidic sperm isolation and insemination device
WO2006079185A1 (en) * 2005-01-31 2006-08-03 The University Of Sydney Apparatus and method for monitoring cell motility
US7708944B1 (en) * 2006-06-13 2010-05-04 Research Foundation Of State University Of New York Ultra-sensitive, portable capillary sensor
US7786888B2 (en) * 2006-10-30 2010-08-31 Honeywell International Inc. False ceiling fire detector assembly
CN101055270B (zh) * 2007-05-30 2011-01-26 北京望升伟业科技发展有限公司 精子活力快速检测试剂盒及其制备和使用方法
CN102016591A (zh) * 2008-03-20 2011-04-13 泰德哈尔·赞巴尔 用于诊断男性生育能力的方法和试剂盒
WO2009121137A1 (en) * 2008-04-01 2009-10-08 Lilian Soon Method for imaging directional cell migration
CN101271105B (zh) * 2008-05-21 2012-12-19 北京望升伟业科技发展有限公司 精子活性快速检测试剂盒及其制备和使用方法
JP2010004770A (ja) * 2008-06-25 2010-01-14 Yuji Tsuji 精子検査器
JP2010252746A (ja) * 2009-04-28 2010-11-11 Nippon Telegr & Teleph Corp <Ntt> 細菌分析装置
JP2010252745A (ja) * 2009-04-28 2010-11-11 Nippon Telegr & Teleph Corp <Ntt> 細菌分析装置
TW201109654A (en) * 2009-09-14 2011-03-16 Univ Nat Taiwan Biochip system, method for determining sperm quality and method for isolating sperm
US20130089876A1 (en) * 2010-04-19 2013-04-11 Research Foundation Of State University Of New York Capillary biosensor system and its method of use
US8828329B2 (en) 2010-10-01 2014-09-09 Church & Dwight, Co., Inc. Electronic analyte assaying device
WO2012126478A1 (en) * 2011-03-21 2012-09-27 Motilitycount Aps Device for analysis of cellular motility
JP6010033B2 (ja) 2011-08-26 2016-10-19 オリンパス株式会社 光分析を用いた単一粒子検出装置、単一粒子検出方法及び単一粒子検出用コンピュータプログラム
WO2013040428A1 (en) 2011-09-14 2013-03-21 Dcb-Usa Llc Microfluidic chips for acquiring sperms with high motility, productions and applications thereof
ES2797452T3 (es) 2012-03-16 2020-12-02 Fertility Innovations Ltd Procesamiento de espermatozoides
EP2840381B1 (de) 2012-04-18 2017-08-09 Olympus Corporation Verfahren zum nachweis von zielpartikeln
EP2840380A4 (de) 2012-04-18 2015-11-25 Olympus Corp Einzelpartikeldetektor mit photoanalysis, einzelpartikelnachweisverfahren und computerprogramm für einzelpartikelnachweis
US9663755B2 (en) 2013-11-19 2017-05-30 The Governing Council Of The University Of Toronto Apparatus and methods for sperm separation
US10422737B2 (en) * 2013-11-20 2019-09-24 The Brigham And Women's Hospital, Inc. System and method for sperm sorting
US10417481B2 (en) * 2015-06-22 2019-09-17 The Brigham And Women's Hospital, Inc. Home evaluation of the quality of semen samples
US10384207B2 (en) 2015-07-21 2019-08-20 Neuro Probe Incorporated Assay apparatus and methods
CA2999683A1 (en) 2015-09-30 2017-04-06 Semen Refinement B.V. Microfluidic device for selection of semen
KR101721086B1 (ko) * 2016-06-17 2017-03-29 김영재 남성 불임 진단 시스템
AR107746A1 (es) * 2017-02-24 2018-05-30 Herberto Ernesto Hector Repetto Dispositivo y método de separación de células móviles
EP3687416A1 (de) 2017-09-29 2020-08-05 Nanovare SAS Vorrichtungen und verfahren zur analyse männlicher unfruchtbarkeit
CN107723237B (zh) * 2017-11-23 2023-12-08 北京大学深圳医院 辅助生殖试验用多用途培养皿
US20200400544A1 (en) * 2017-12-15 2020-12-24 Ams International Ag Integrated filter-based particulate matter sensors
CN109470672A (zh) * 2018-12-06 2019-03-15 大连海事大学 多光强激发检测单个微藻细胞活性的装置与方法
CN110339876B (zh) * 2019-06-27 2021-04-30 昆明理工大学 一种基于液滴寄存的肿瘤细胞筛查微流控装置及筛查方法

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Also Published As

Publication number Publication date
ATE433103T1 (de) 2009-06-15
WO2004053465A2 (en) 2004-06-24
US7108966B2 (en) 2006-09-19
JP2006511825A (ja) 2006-04-06
CA2507031A1 (en) 2004-06-24
US20050130122A1 (en) 2005-06-16
JP4529019B2 (ja) 2010-08-25
WO2004053465A3 (en) 2004-11-11
EP1581798A2 (de) 2005-10-05
US20040146850A1 (en) 2004-07-29
US6929945B2 (en) 2005-08-16
KR20050085471A (ko) 2005-08-29
AU2003297757B2 (en) 2009-12-24
AU2003297757A1 (en) 2004-06-30
EP1581798B1 (de) 2009-06-03

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