DE60325894D1 - Stereoselektiver prozess zur herstellung von nukleosidanalogen dioxolan-derivaten - Google Patents
Stereoselektiver prozess zur herstellung von nukleosidanalogen dioxolan-derivatenInfo
- Publication number
- DE60325894D1 DE60325894D1 DE60325894T DE60325894T DE60325894D1 DE 60325894 D1 DE60325894 D1 DE 60325894D1 DE 60325894 T DE60325894 T DE 60325894T DE 60325894 T DE60325894 T DE 60325894T DE 60325894 D1 DE60325894 D1 DE 60325894D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- lipase
- preparation
- compound
- nucleoside analogue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical class C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 title 1
- 229940127073 nucleoside analogue Drugs 0.000 title 1
- 230000000707 stereoselective effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 108090001060 Lipase Proteins 0.000 abstract 3
- 102000004882 Lipase Human genes 0.000 abstract 3
- 239000004367 Lipase Substances 0.000 abstract 3
- 229940040461 lipase Drugs 0.000 abstract 3
- 235000019421 lipase Nutrition 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 241001661345 Moesziomyces antarcticus Species 0.000 abstract 2
- 230000002255 enzymatic effect Effects 0.000 abstract 2
- 229940088598 enzyme Drugs 0.000 abstract 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 abstract 1
- 108090000371 Esterases Proteins 0.000 abstract 1
- 102000019280 Pancreatic lipases Human genes 0.000 abstract 1
- 108050006759 Pancreatic lipases Proteins 0.000 abstract 1
- 101000968489 Rhizomucor miehei Lipase Proteins 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 229940116369 pancreatic lipase Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42682102P | 2002-11-18 | 2002-11-18 | |
PCT/CA2003/001798 WO2004048590A1 (en) | 2002-11-18 | 2003-11-18 | Stereoselective process for the production of dioxolane nucleoside analogues |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60325894D1 true DE60325894D1 (de) | 2009-03-05 |
Family
ID=32393318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60325894T Expired - Lifetime DE60325894D1 (de) | 2002-11-18 | 2003-11-18 | Stereoselektiver prozess zur herstellung von nukleosidanalogen dioxolan-derivaten |
Country Status (9)
Country | Link |
---|---|
US (1) | US7955835B2 (ja) |
EP (1) | EP1573019B1 (ja) |
JP (1) | JP4501135B2 (ja) |
AT (1) | ATE420972T1 (ja) |
AU (1) | AU2003285230B2 (ja) |
CA (1) | CA2505552C (ja) |
DE (1) | DE60325894D1 (ja) |
ES (1) | ES2318179T3 (ja) |
WO (1) | WO2004048590A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050085638A1 (en) * | 2002-01-25 | 2005-04-21 | Shire Biochem Inc | Process for producing dioxolane nucleoside analogues |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ250842A (en) * | 1991-02-22 | 1996-03-26 | Univ Emory | Resolution of a racemic mixture of nucleoside enantiomers such as 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane (ftc) |
DK1140937T3 (da) | 1998-12-23 | 2004-03-22 | Shire Biochem Inc | Antivirale nucleosid-analoger |
AU2653200A (en) | 1999-02-11 | 2000-08-29 | Biochem Pharma Inc. | Stereoselective synthesis of nucleoside analogues |
-
2003
- 2003-11-18 WO PCT/CA2003/001798 patent/WO2004048590A1/en active Application Filing
- 2003-11-18 CA CA2505552A patent/CA2505552C/en not_active Expired - Lifetime
- 2003-11-18 DE DE60325894T patent/DE60325894D1/de not_active Expired - Lifetime
- 2003-11-18 US US10/535,235 patent/US7955835B2/en active Active
- 2003-11-18 AT AT03778180T patent/ATE420972T1/de not_active IP Right Cessation
- 2003-11-18 ES ES03778180T patent/ES2318179T3/es not_active Expired - Lifetime
- 2003-11-18 AU AU2003285230A patent/AU2003285230B2/en not_active Expired
- 2003-11-18 JP JP2004554100A patent/JP4501135B2/ja not_active Expired - Lifetime
- 2003-11-18 EP EP03778180A patent/EP1573019B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2004048590A1 (en) | 2004-06-10 |
US7955835B2 (en) | 2011-06-07 |
JP4501135B2 (ja) | 2010-07-14 |
EP1573019B1 (en) | 2009-01-14 |
AU2003285230A1 (en) | 2004-06-18 |
CA2505552C (en) | 2012-06-05 |
CA2505552A1 (en) | 2004-06-10 |
JP2006506096A (ja) | 2006-02-23 |
ATE420972T1 (de) | 2009-01-15 |
US20060134763A1 (en) | 2006-06-22 |
ES2318179T3 (es) | 2009-05-01 |
AU2003285230B2 (en) | 2010-04-22 |
EP1573019A1 (en) | 2005-09-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60238745D1 (de) | Glucosamin und verfahren zur herstellung von glucosamin aus mikrobieller biomasse | |
ATE340857T1 (de) | Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadph | |
ATE414162T1 (de) | Verfahren und materialien zur herstellung von glucosamin | |
DE60326621D1 (de) | Verfahren zur herstellung eines sputtertargets und sputtertarget | |
DK0629701T3 (da) | Enzymatisk hydrolysemetode til fremstilling af C-10 og C-13 hydroxylbærende taxaner, enzymatisk esterificeringsmetode til f | |
ATE501264T1 (de) | Enzymatische verfahren zur herstellung 4- substituierter 3-hydroxybuttersäure-derivate | |
DE60322708D1 (de) | Glucosesensor unter verwendung von glucosedehydrogenase | |
BR0307349A (pt) | Processos para fermentar uma composição de fitoesterol e para preparar androestadienodiona a partir da androestenodiona, fusarium solani fmi 33, e, composição | |
KR100897457B1 (ko) | 탁수스종의세포배양에의한탁산의생산증진방법 | |
TW200619387A (en) | Lipase powder composition and method for producing esterified product using the same | |
Jacobsen et al. | Enantioselective enzymatic preparation of chiral glutaric monocarboxylic acids and amides | |
DE60325894D1 (de) | Stereoselektiver prozess zur herstellung von nukleosidanalogen dioxolan-derivaten | |
ATE170924T1 (de) | Verfahren zur veresterung von carbonsäuren mit tertiären alkoholen | |
NZ508404A (en) | Alcoholic fermentation using a mineral-enriched yeast as a nutrient source | |
ATE386134T1 (de) | Verfahren zur herstellung von glutathion | |
JP2769194B2 (ja) | 酵素分解方法 | |
EE05498B1 (et) | Butnool-I-esteraas | |
ATE386132T1 (de) | Verfahren zur enantioselektiven öffnung von 3- substituierten oxetan-2-onen unter verwendung der lipasen von candida antarctica oder von burkholderia plantarii | |
HUP9903899A2 (hu) | Eljárás L-aminosavak fermentációs előállítására | |
CA2354382C (en) | Process for preparing optically active 1-amino-4-(hydroxymethyl) cyclopent-2-ene derivatives | |
KR880701287A (ko) | 광학적으로 활성인 1,2-디하이드로-3H-피롤로(1, 2a)피롤-1-카복실산 유도체의 제조방법 | |
TW200639257A (en) | Enzymatic synthesis method for a triglyceride of a phenylfatty acid | |
WO2004081220A3 (en) | A process for enzymatically resolving an enantiomeric mixture of alpha-hydroxy acids | |
ATE211505T1 (de) | Verfahren zur enzymatischen herstellung eines synthese-zwischenprodukt von befloxatone | |
ATE422552T1 (de) | Verfahren zur enzymatischen reduktion von nad und nadp |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: SHIRE CANADA INC., VILLE ST.-LAURENT, QUEBEC, CA |
|
8364 | No opposition during term of opposition |