DE60320844D1 - Kristallstruktur der glutamatracemase (muri) - Google Patents

Kristallstruktur der glutamatracemase (muri)

Info

Publication number
DE60320844D1
DE60320844D1 DE60320844T DE60320844T DE60320844D1 DE 60320844 D1 DE60320844 D1 DE 60320844D1 DE 60320844 T DE60320844 T DE 60320844T DE 60320844 T DE60320844 T DE 60320844T DE 60320844 D1 DE60320844 D1 DE 60320844D1
Authority
DE
Germany
Prior art keywords
muri
glutamatracemase
crystal structure
inhibitors
screening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60320844T
Other languages
English (en)
Inventor
Marie Anderson
Stewart Lindsay Fisher
Rutger Henk Folmer
Gunther Kern
Rolf Tomas Lundqvist
David Trevor Newton
Yafeng Xue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE60320844D1 publication Critical patent/DE60320844D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Piezo-Electric Or Mechanical Vibrators, Or Delay Or Filter Circuits (AREA)
  • Magnetic Heads (AREA)
DE60320844T 2002-12-20 2003-12-08 Kristallstruktur der glutamatracemase (muri) Expired - Fee Related DE60320844D1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US43552702P 2002-12-20 2002-12-20
US43516702P 2002-12-20 2002-12-20
US43527202P 2002-12-20 2002-12-20
US43508702P 2002-12-20 2002-12-20
PCT/US2003/038977 WO2004061097A2 (en) 2002-12-20 2003-12-08 Crystal structure of glutamate racemase (muri)

Publications (1)

Publication Number Publication Date
DE60320844D1 true DE60320844D1 (de) 2008-06-19

Family

ID=32719501

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60320844T Expired - Fee Related DE60320844D1 (de) 2002-12-20 2003-12-08 Kristallstruktur der glutamatracemase (muri)

Country Status (7)

Country Link
US (1) US20050037478A1 (de)
EP (1) EP1573000B1 (de)
AT (1) ATE394480T1 (de)
AU (1) AU2003302328A1 (de)
DE (1) DE60320844D1 (de)
ES (1) ES2305570T3 (de)
WO (1) WO2004061097A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2078091A4 (de) * 2007-07-10 2010-09-01 Medimmune Llc Kristalle und struktur der menschlichen igg-fc-variante
EP2700631B1 (de) * 2008-10-15 2015-07-08 Ohio Northern University Modell für Glutamatracemasehemmer und antibakterielle Glutamatracemase-Wirkstoffe
US8236849B2 (en) 2008-10-15 2012-08-07 Ohio Northern University Model for glutamate racemase inhibitors and glutamate racemase antibacterial agents
CN109576200A (zh) * 2019-01-10 2019-04-05 鲁东大学 一种产谷氨酸消旋酶的重组菌及其构建方法和应用
CN111979208B (zh) * 2019-05-23 2023-01-10 弈柯莱生物科技(上海)股份有限公司 一种l-谷氨酸脱氢酶突变体及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002014261A2 (en) * 2000-08-10 2002-02-21 Eli Lilly And Company 4-substituted d-glutamic acid derivatives for use as antibiotic

Also Published As

Publication number Publication date
ATE394480T1 (de) 2008-05-15
AU2003302328A1 (en) 2004-07-29
EP1573000A2 (de) 2005-09-14
WO2004061097A2 (en) 2004-07-22
ES2305570T3 (es) 2008-11-01
EP1573000B1 (de) 2008-05-07
WO2004061097A3 (en) 2004-09-23
AU2003302328A8 (en) 2004-07-29
US20050037478A1 (en) 2005-02-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee