DE60316595D1 - Sperrschicht für wirkstoffhaltige polymere beschichtungen - Google Patents

Sperrschicht für wirkstoffhaltige polymere beschichtungen

Info

Publication number
DE60316595D1
DE60316595D1 DE60316595T DE60316595T DE60316595D1 DE 60316595 D1 DE60316595 D1 DE 60316595D1 DE 60316595 T DE60316595 T DE 60316595T DE 60316595 T DE60316595 T DE 60316595T DE 60316595 D1 DE60316595 D1 DE 60316595D1
Authority
DE
Germany
Prior art keywords
barrier
separating layer
active polymer
polymer coatings
apposition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60316595T
Other languages
English (en)
Other versions
DE60316595T2 (de
Inventor
Laurie R Lawin
Michelle C Boucha-Rayle
Timothy M Kloke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Surmodics Inc
Original Assignee
Surmodics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surmodics Inc filed Critical Surmodics Inc
Application granted granted Critical
Publication of DE60316595D1 publication Critical patent/DE60316595D1/de
Publication of DE60316595T2 publication Critical patent/DE60316595T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Paints Or Removers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
DE60316595T 2002-12-06 2003-12-05 Sperrschicht für wirkstoffhaltige polymere beschichtungen Expired - Lifetime DE60316595T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US313234 2002-12-06
US10/313,234 US20040111144A1 (en) 2002-12-06 2002-12-06 Barriers for polymeric coatings
PCT/US2003/038788 WO2004052420A2 (en) 2002-12-06 2003-12-05 Barriers for bioactive agent-containing polymeric coatings

Publications (2)

Publication Number Publication Date
DE60316595D1 true DE60316595D1 (de) 2007-11-08
DE60316595T2 DE60316595T2 (de) 2008-10-23

Family

ID=32468185

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60316595T Expired - Lifetime DE60316595T2 (de) 2002-12-06 2003-12-05 Sperrschicht für wirkstoffhaltige polymere beschichtungen

Country Status (8)

Country Link
US (2) US20040111144A1 (de)
EP (1) EP1567203B1 (de)
JP (2) JP2006511261A (de)
AT (1) ATE374050T1 (de)
AU (1) AU2003298006A1 (de)
CA (1) CA2503831C (de)
DE (1) DE60316595T2 (de)
WO (1) WO2004052420A2 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
ATE466603T1 (de) * 1998-04-27 2010-05-15 Surmodics Inc Bioaktive wirkstoffe freisetzende beschichtungen
US20020188037A1 (en) * 1999-04-15 2002-12-12 Chudzik Stephen J. Method and system for providing bioactive agent release coating
US7700819B2 (en) 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
US7763769B2 (en) * 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
US20030032874A1 (en) 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US7828728B2 (en) 2003-07-25 2010-11-09 Dexcom, Inc. Analyte sensor
US7097850B2 (en) 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
US7125476B2 (en) * 2003-01-30 2006-10-24 The United States Of America As Represented By The Secretary Of The Navy Microwave-attenuating composite materials, methods for preparing the same, intermediates for preparing the same, devices containing the same, methods of preparing such a device, and methods of attenuating microwaves
US20040230298A1 (en) * 2003-04-25 2004-11-18 Medtronic Vascular, Inc. Drug-polymer coated stent with polysulfone and styrenic block copolymer
EP1648298A4 (de) 2003-07-25 2010-01-13 Dexcom Inc Sauerstoffverbessernde membransysteme für implantierbare vorrichtungen
US20070275156A1 (en) * 2003-11-28 2007-11-29 Masaru Tanaka Cell Growth Inhibiting Film, Medical Instrument and Digestive System Stent
DE602005015564D1 (de) * 2004-04-06 2009-09-03 Surmodics Inc Beschichtungszusammensetzungen für bioaktive mittel
US8277713B2 (en) 2004-05-03 2012-10-02 Dexcom, Inc. Implantable analyte sensor
GB0414099D0 (en) * 2004-06-23 2004-07-28 Univ Glasgow Biocompatible layered structures and methods for their manufacture
US7648727B2 (en) * 2004-08-26 2010-01-19 Advanced Cardiovascular Systems, Inc. Methods for manufacturing a coated stent-balloon assembly
JP5155146B2 (ja) * 2005-03-15 2013-02-27 サーモディクス，インコーポレイティド 挿入可能な医療器具用の柔軟性ポリマー被膜
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
US20060257355A1 (en) * 2005-05-10 2006-11-16 Abiomed, Inc. Impregnated polymer compositions and devices using them
US8182890B2 (en) * 2007-01-19 2012-05-22 Elixir Medical Corporation Biodegradable endoprostheses and methods for their fabrication
US8814930B2 (en) 2007-01-19 2014-08-26 Elixir Medical Corporation Biodegradable endoprosthesis and methods for their fabrication
RU2447901C2 (ru) 2007-01-21 2012-04-20 Хемотек Аг Медицинский продукт для лечения обтураций просветов организма и для предупреждения угрожающих повторных обтураций
DE102007008479A1 (de) 2007-02-21 2008-09-04 Orlowski, Michael, Dr. Beschichtetes Expandierbares System
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
CN102047101A (zh) * 2008-03-28 2011-05-04 德克斯康公司 用于连续的分析物传感器的聚合物膜
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US20100008966A1 (en) * 2008-07-14 2010-01-14 Surmodics, Inc. Medical Devices and Methods for Delivery of Nucleic Acids
US8560039B2 (en) 2008-09-19 2013-10-15 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
EP3064230B1 (de) 2009-07-10 2019-04-10 Boston Scientific Scimed, Inc. Verwendung von nanokristallen für einen wirkstofffreisetzungsballon
WO2011008393A2 (en) * 2009-07-17 2011-01-20 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
WO2011059123A1 (ko) * 2009-11-11 2011-05-19 주식회사 메디프렉스 접착성 물질과 결합된 헤파린 화합물, 이의 제조방법, 이를 유효성분으로 함유하는 고체 표면 코팅제, 및 이를 이용한 고체 표면의 코팅방법
US20110160645A1 (en) * 2009-12-31 2011-06-30 Boston Scientific Scimed, Inc. Cryo Activated Drug Delivery and Cutting Balloons
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
WO2013146376A1 (ja) 2012-03-27 2013-10-03 テルモ株式会社 コーティング組成物および医療機器
US9855156B2 (en) 2014-08-15 2018-01-02 Elixir Medical Corporation Biodegradable endoprostheses and methods of their fabrication
US9259339B1 (en) 2014-08-15 2016-02-16 Elixir Medical Corporation Biodegradable endoprostheses and methods of their fabrication
US9480588B2 (en) 2014-08-15 2016-11-01 Elixir Medical Corporation Biodegradable endoprostheses and methods of their fabrication
US9730819B2 (en) 2014-08-15 2017-08-15 Elixir Medical Corporation Biodegradable endoprostheses and methods of their fabrication
JP5874859B1 (ja) * 2014-12-12 2016-03-02 東洋インキＳｃホールディングス株式会社 体液接触用医療用具および生体適合性重合体
CN104874090A (zh) * 2015-03-20 2015-09-02 深圳市信立泰生物医疗工程有限公司 一种新型药物洗脱球囊导管
US11622872B2 (en) 2016-05-16 2023-04-11 Elixir Medical Corporation Uncaging stent
EP3457985B1 (de) 2016-05-16 2021-02-17 Elixir Medical Corporation Expansionsstent

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069307A (en) * 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US4391797A (en) * 1977-01-05 1983-07-05 The Children's Hospital Medical Center Systems for the controlled release of macromolecules
US4292965A (en) * 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
DE2920500A1 (de) * 1979-05-21 1980-11-27 Boehringer Sohn Ingelheim Pharmazeutische zubereitung in form eines polyacrylatfilmes
US5310559A (en) * 1982-09-01 1994-05-10 Hercon Laboratories Corporation Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer
US4973493A (en) * 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US5217492A (en) * 1982-09-29 1993-06-08 Bio-Metric Systems, Inc. Biomolecule attachment to hydrophobic surfaces
US5512329A (en) * 1982-09-29 1996-04-30 Bsi Corporation Substrate surface preparation
US4722906A (en) * 1982-09-29 1988-02-02 Bio-Metric Systems, Inc. Binding reagents and methods
US5002582A (en) * 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
US5258041A (en) * 1982-09-29 1993-11-02 Bio-Metric Systems, Inc. Method of biomolecule attachment to hydrophobic surfaces
US4603152A (en) * 1982-11-05 1986-07-29 Baxter Travenol Laboratories, Inc. Antimicrobial compositions
US4693887A (en) * 1983-09-15 1987-09-15 The Kendall Company Microphase separated hydrogels for controlled release of bioactive materials
DE3344691A1 (de) * 1983-12-10 1985-06-20 Bayer Ag, 5090 Leverkusen Wirkstoffabgasesysteme
DE3347278A1 (de) * 1983-12-28 1985-07-11 Bayer Ag, 5090 Leverkusen Wirkstoffabgabesysteme
US4826759A (en) * 1984-10-04 1989-05-02 Bio-Metric Systems, Inc. Field assay for ligands
WO1987004935A1 (en) * 1986-02-24 1987-08-27 Fischell Robert An intravascular stent and percutaneous insertion system
US4959217A (en) * 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules
US4979959A (en) * 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
US5263992A (en) * 1986-10-17 1993-11-23 Bio-Metric Systems, Inc. Biocompatible device with covalently bonded biocompatible agent
US5114719A (en) * 1987-04-29 1992-05-19 Sabel Bernhard A Extended drug delivery of small, water-soluble molecules
US4968539A (en) * 1987-12-01 1990-11-06 Lion Corporation Liquid crystal membrane
US4916193A (en) * 1987-12-17 1990-04-10 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US4867968A (en) * 1987-12-29 1989-09-19 Florida-Kansas Health Care, Inc. Elastomeric composition containing therapeutic agents and articles manufactured therefrom
US5019096A (en) * 1988-02-11 1991-05-28 Trustees Of Columbia University In The City Of New York Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
US5024742A (en) * 1988-02-24 1991-06-18 Cedars-Sinai Medical Center Method of crosslinking amino acid containing polymers using photoactivatable chemical crosslinkers
US5165952A (en) * 1989-01-18 1992-11-24 Becton, Dickinson And Company Anti-infective and antithrombogenic medical articles and method for their preparation
US4994071A (en) * 1989-05-22 1991-02-19 Cordis Corporation Bifurcating stent apparatus and method
WO1991003990A1 (en) * 1989-09-15 1991-04-04 Chiron Ophthalmics, Inc. Method for achieving epithelialization of synthetic lenses
US5674192A (en) * 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US5304121A (en) * 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
AU7998091A (en) * 1990-05-17 1991-12-10 Harbor Medical Devices, Inc. Medical device polymer
US5180366A (en) * 1990-10-10 1993-01-19 Woods W T Apparatus and method for angioplasty and for preventing re-stenosis
US5437656A (en) * 1991-02-27 1995-08-01 Leonard Bloom Method and device for inhibiting H.I.V. hepatitis B and other viruses and germs when using a needle, scalpel and other sharp instrument in a medical environment
US5221698A (en) * 1991-06-27 1993-06-22 The Regents Of The University Of Michigan Bioactive composition
US5356433A (en) * 1991-08-13 1994-10-18 Cordis Corporation Biocompatible metal surfaces
AU3664693A (en) * 1992-02-13 1993-09-03 Bio-Metric Systems, Inc. Immobilization of chemical species in crosslinked matrices
US5248732A (en) * 1992-06-01 1993-09-28 Enichem S.P.A. Blends of polyetherimides, aromatic alkyl methacrylates and polycarbonates
US5414075A (en) * 1992-11-06 1995-05-09 Bsi Corporation Restrained multifunctional reagent for surface modification
US5342348A (en) * 1992-12-04 1994-08-30 Kaplan Aaron V Method and device for treating and enlarging body lumens
US5419760A (en) * 1993-01-08 1995-05-30 Pdt Systems, Inc. Medicament dispensing stent for prevention of restenosis of a blood vessel
US20020055710A1 (en) * 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
US5464650A (en) * 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5380299A (en) * 1993-08-30 1995-01-10 Med Institute, Inc. Thrombolytic treated intravascular medical device
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
CA2176934A1 (en) * 1993-11-17 1995-05-26 Ramnath Sasisekharan Method for inhibiting angiogenesis using heparinase
EP0772467A1 (de) * 1994-07-22 1997-05-14 Advanced Cardiovascular Systems, Inc. Hydrophiles beschichtungsmaterial für intrakoporelle verwenudng
WO1996025897A2 (en) * 1995-02-22 1996-08-29 Menlo Care, Inc. Covered expanding mesh stent
US6099562A (en) * 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
EP1018977B1 (de) * 1995-05-26 2004-12-08 SurModics, Inc. Verfahren und implantierbarer gegenstand zur förderung der endothelialisierung
US6774278B1 (en) * 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US5783502A (en) * 1995-06-07 1998-07-21 Bsi Corporation Virus inactivating coatings
US5722424A (en) * 1995-09-29 1998-03-03 Target Therapeutics, Inc. Multi-coating stainless steel guidewire
US5714360A (en) * 1995-11-03 1998-02-03 Bsi Corporation Photoactivatable water soluble cross-linking agents containing an onium group
US5981298A (en) * 1995-12-13 1999-11-09 Surmodics, Inc. Immunoassay device and method
US5942555A (en) * 1996-03-21 1999-08-24 Surmodics, Inc. Photoactivatable chain transfer agents and semi-telechelic photoactivatable polymers prepared therefrom
US6121027A (en) * 1997-08-15 2000-09-19 Surmodics, Inc. Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups
US5858653A (en) * 1997-09-30 1999-01-12 Surmodics, Inc. Reagent and method for attaching target molecules to a surface
US20020164374A1 (en) * 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
US6221425B1 (en) * 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
US6007833A (en) * 1998-03-19 1999-12-28 Surmodics, Inc. Crosslinkable macromers bearing initiator groups
ATE466603T1 (de) * 1998-04-27 2010-05-15 Surmodics Inc Bioaktive wirkstoffe freisetzende beschichtungen
US6335029B1 (en) * 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
US6254609B1 (en) * 1999-01-11 2001-07-03 Scimed Life Systems, Inc. Self-expanding stent delivery system with two sheaths
US6530950B1 (en) * 1999-01-12 2003-03-11 Quanam Medical Corporation Intraluminal stent having coaxial polymer member
US6331186B1 (en) * 1999-03-22 2001-12-18 Scimed Life Systems, Inc. End sleeve coating for stent delivery
US6607598B2 (en) * 1999-04-19 2003-08-19 Scimed Life Systems, Inc. Device for protecting medical devices during a coating process
US6176849B1 (en) * 1999-05-21 2001-01-23 Scimed Life Systems, Inc. Hydrophilic lubricity coating for medical devices comprising a hydrophobic top coat
US6325807B1 (en) * 1999-06-11 2001-12-04 Scimed Life Systems, Inc. Variable strength sheath
AU774553B2 (en) * 1999-06-24 2004-07-01 Biocompatibles Limited Balloon expandable stent
US6800073B2 (en) * 1999-10-28 2004-10-05 Scimed Life Systems, Inc. Biocompatible pharmaceutical articles
WO2001036008A2 (en) * 1999-11-18 2001-05-25 Sts Biopolymers, Inc. Medical devices coated with elastic polymeric material
US6251136B1 (en) * 1999-12-08 2001-06-26 Advanced Cardiovascular Systems, Inc. Method of layering a three-coated stent using pharmacological and polymeric agents
US6908624B2 (en) * 1999-12-23 2005-06-21 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US20020007213A1 (en) * 2000-05-19 2002-01-17 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US6451373B1 (en) * 2000-08-04 2002-09-17 Advanced Cardiovascular Systems, Inc. Method of forming a therapeutic coating onto a surface of an implantable prosthesis
US20020111590A1 (en) * 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
US6545097B2 (en) * 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
US6517520B2 (en) * 2000-12-21 2003-02-11 Ethicon Endo Surgery, Inc. Peripherally inserted catheter with flushable guide-tube
GB0100761D0 (en) * 2001-01-11 2001-02-21 Biocompatibles Ltd Drug delivery from stents
US7771468B2 (en) * 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
CA2747159A1 (en) * 2001-05-07 2002-11-07 Queen's University At Kingston Biodegradable elastomer and method of preparing same
US20040058056A1 (en) * 2001-07-06 2004-03-25 Shigemasa Osaki Drug diffusion coatings, applications and methods
US6753071B1 (en) * 2001-09-27 2004-06-22 Advanced Cardiovascular Systems, Inc. Rate-reducing membrane for release of an agent
US20030065377A1 (en) * 2001-09-28 2003-04-03 Davila Luis A. Coated medical devices
US7682387B2 (en) * 2002-04-24 2010-03-23 Biosensors International Group, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US7585516B2 (en) * 2001-11-12 2009-09-08 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices
US20030204168A1 (en) * 2002-04-30 2003-10-30 Gjalt Bosma Coated vascular devices
US7655038B2 (en) * 2003-02-28 2010-02-02 Biointeractions Ltd. Polymeric network system for medical devices and methods of use
US20040054104A1 (en) * 2002-09-05 2004-03-18 Pacetti Stephen D. Coatings for drug delivery devices comprising modified poly(ethylene-co-vinyl alcohol)
US6800663B2 (en) * 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
US7241455B2 (en) * 2003-04-08 2007-07-10 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent
US7279174B2 (en) * 2003-05-08 2007-10-09 Advanced Cardiovascular Systems, Inc. Stent coatings comprising hydrophilic additives
NL1023720C2 (nl) * 2003-06-23 2004-12-28 Univ Eindhoven Tech Werkwijze voor het wijzigen van de transporteigenschappen van een materiaal, werkwijze voor het vrijmaken van een werkstof uit een implantaat, evenals implantaat met werkstof.
US9114199B2 (en) * 2003-07-31 2015-08-25 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing acrylic copolymer for controlled delivery of therapeutic agent
US20050064011A1 (en) * 2003-08-11 2005-03-24 Young-Ho Song Implantable or insertable medical devices containing phenolic compound for inhibition of restenosis
US20050037047A1 (en) * 2003-08-11 2005-02-17 Young-Ho Song Medical devices comprising spray dried microparticles
US20050037048A1 (en) * 2003-08-11 2005-02-17 Young-Ho Song Medical devices containing antioxidant and therapeutic agent
CA2535346A1 (en) * 2003-08-13 2005-03-03 Medtronic, Inc. Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices, and methods
US20050037052A1 (en) * 2003-08-13 2005-02-17 Medtronic Vascular, Inc. Stent coating with gradient porosity
EP1684820A2 (de) * 2003-08-13 2006-08-02 Medtronic, Inc. Systeme zur abgabe von wirkstoffen mit einer mischbaren polymermischung, medizinprodukte und -verfahren

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EP1567203B1 (de) 2007-09-26
CA2503831A1 (en) 2004-06-24
WO2004052420A2 (en) 2004-06-24
JP2006346492A (ja) 2006-12-28
AU2003298006A8 (en) 2004-06-30
ATE374050T1 (de) 2007-10-15
WO2004052420A3 (en) 2004-07-22
JP2006511261A (ja) 2006-04-06
US20080031918A1 (en) 2008-02-07
EP1567203A2 (de) 2005-08-31
CA2503831C (en) 2010-10-26
AU2003298006A1 (en) 2004-06-30
DE60316595T2 (de) 2008-10-23
US20040111144A1 (en) 2004-06-10

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