DE60315417D1 - Verfahren zur herstellung von losartan kaliumsalz mit verbesserten fliesseigenschaften - Google Patents
Verfahren zur herstellung von losartan kaliumsalz mit verbesserten fliesseigenschaftenInfo
- Publication number
- DE60315417D1 DE60315417D1 DE60315417T DE60315417T DE60315417D1 DE 60315417 D1 DE60315417 D1 DE 60315417D1 DE 60315417 T DE60315417 T DE 60315417T DE 60315417 T DE60315417 T DE 60315417T DE 60315417 D1 DE60315417 D1 DE 60315417D1
- Authority
- DE
- Germany
- Prior art keywords
- flow properties
- improved flow
- calium
- salt
- preparing losartan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002083 C09CA01 - Losartan Substances 0.000 title abstract 2
- KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 title 1
- 229960004773 losartan Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 229960000519 losartan potassium Drugs 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41945002P | 2002-10-17 | 2002-10-17 | |
| US419450P | 2002-10-17 | ||
| US42607202P | 2002-11-12 | 2002-11-12 | |
| US426072P | 2002-11-12 | ||
| US42646102P | 2002-11-14 | 2002-11-14 | |
| US426461P | 2002-11-14 | ||
| US43145002P | 2002-12-04 | 2002-12-04 | |
| US431450P | 2002-12-04 | ||
| US43180902P | 2002-12-09 | 2002-12-09 | |
| US431809P | 2002-12-09 | ||
| PCT/US2003/032885 WO2004035049A1 (en) | 2002-10-17 | 2003-10-17 | Process for preparing losartan potassium with improved flowability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60315417D1 true DE60315417D1 (de) | 2007-09-20 |
| DE60315417T2 DE60315417T2 (de) | 2008-04-30 |
Family
ID=32111134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60315417T Expired - Fee Related DE60315417T2 (de) | 2002-10-17 | 2003-10-17 | Verfahren zur herstellung von losartan kaliumsalz mit verbesserten fliesseigenschaften |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20040171843A1 (de) |
| EP (1) | EP1471908B1 (de) |
| AT (1) | ATE369132T1 (de) |
| AU (1) | AU2003284262A1 (de) |
| DE (1) | DE60315417T2 (de) |
| ES (1) | ES2290518T3 (de) |
| WO (1) | WO2004035049A1 (de) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3249827B2 (ja) * | 1996-10-29 | 2002-01-21 | メルク エンド カンパニー インコーポレーテッド | ロサルタンの結晶化法 |
| CN1612866A (zh) * | 2001-11-14 | 2005-05-04 | 特瓦制药工业有限公司 | 无定形和结晶形的氯沙坦钾及其制备方法 |
-
2003
- 2003-10-17 EP EP03776442A patent/EP1471908B1/de not_active Expired - Lifetime
- 2003-10-17 AU AU2003284262A patent/AU2003284262A1/en not_active Abandoned
- 2003-10-17 US US10/688,697 patent/US20040171843A1/en not_active Abandoned
- 2003-10-17 WO PCT/US2003/032885 patent/WO2004035049A1/en active IP Right Grant
- 2003-10-17 DE DE60315417T patent/DE60315417T2/de not_active Expired - Fee Related
- 2003-10-17 ES ES03776442T patent/ES2290518T3/es not_active Expired - Lifetime
- 2003-10-17 AT AT03776442T patent/ATE369132T1/de not_active IP Right Cessation
-
2006
- 2006-04-13 US US11/404,368 patent/US20060241161A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE369132T1 (de) | 2007-08-15 |
| US20040171843A1 (en) | 2004-09-02 |
| AU2003284262A8 (en) | 2004-05-04 |
| EP1471908A1 (de) | 2004-11-03 |
| EP1471908B1 (de) | 2007-08-08 |
| ES2290518T3 (es) | 2008-02-16 |
| US20060241161A1 (en) | 2006-10-26 |
| WO2004035049A1 (en) | 2004-04-29 |
| AU2003284262A1 (en) | 2004-05-04 |
| DE60315417T2 (de) | 2008-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |