DE60313967D1 - Verfahren zur entwicklung von pdk1-modulatoren - Google Patents
Verfahren zur entwicklung von pdk1-modulatorenInfo
- Publication number
- DE60313967D1 DE60313967D1 DE60313967T DE60313967T DE60313967D1 DE 60313967 D1 DE60313967 D1 DE 60313967D1 DE 60313967 T DE60313967 T DE 60313967T DE 60313967 T DE60313967 T DE 60313967T DE 60313967 D1 DE60313967 D1 DE 60313967D1
- Authority
- DE
- Germany
- Prior art keywords
- pdk1
- protein kinase
- selecting
- compound
- modulators
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101000600756 Homo sapiens 3-phosphoinositide-dependent protein kinase 1 Proteins 0.000 title abstract 5
- 101001117146 Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Proteins 0.000 title abstract 5
- 102100024148 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Human genes 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 102000001253 Protein Kinase Human genes 0.000 abstract 3
- 108060006633 protein kinase Proteins 0.000 abstract 3
- 230000003197 catalytic effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000002209 hydrophobic effect Effects 0.000 abstract 2
- 101001031598 Dictyostelium discoideum Probable serine/threonine-protein kinase fhkC Proteins 0.000 abstract 1
- 102000006335 Phosphate-Binding Proteins Human genes 0.000 abstract 1
- 108010058514 Phosphate-Binding Proteins Proteins 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 150000003906 phosphoinositides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C43/00—Alloys containing radioactive materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Materials Engineering (AREA)
- Biotechnology (AREA)
- Metallurgy (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Liquid Developers In Electrophotography (AREA)
- Liquid Crystal Substances (AREA)
- Materials For Photolithography (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Manufacture And Refinement Of Metals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0213186.0A GB0213186D0 (en) | 2002-06-08 | 2002-06-08 | Methods |
| GB0213186 | 2002-06-08 | ||
| PCT/GB2003/002509 WO2003104481A2 (en) | 2002-06-08 | 2003-06-09 | Methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60313967D1 true DE60313967D1 (de) | 2007-07-05 |
| DE60313967T2 DE60313967T2 (de) | 2008-01-17 |
Family
ID=9938208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60313967T Expired - Lifetime DE60313967T2 (de) | 2002-06-08 | 2003-06-09 | Verfahren zur entwicklung von pdk1-modulatoren |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7792665B2 (de) |
| EP (1) | EP1513947B1 (de) |
| AT (1) | ATE362993T1 (de) |
| AU (1) | AU2003241038A1 (de) |
| DE (1) | DE60313967T2 (de) |
| GB (1) | GB0213186D0 (de) |
| WO (1) | WO2003104481A2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006020755A2 (en) * | 2004-08-10 | 2006-02-23 | Beth Israel Deaconess Medical Center, Inc. | Methods for identifying inhibitors of the mtor pathway as diabetes therapeutics |
| WO2008019890A2 (en) * | 2006-08-18 | 2008-02-21 | Biondi Ricardo M | Method of modulation of protein phosphorylation-dependent conformational transitions with low molecular weight compounds |
| EP2182058A1 (de) | 2008-10-17 | 2010-05-05 | Universität des Saarlandes | Hochauflösende Struktur der Proteinkinase-PDK1 und allosterische Effekte niedermolekularer Aktivatoren |
| CN102713618B (zh) | 2009-09-16 | 2015-07-15 | 新基阿维罗米克斯研究公司 | 蛋白激酶复合物和抑制剂 |
| AU2010339456A1 (en) * | 2009-12-30 | 2012-07-05 | Celgene Avilomics Research, Inc. | Ligand-directed covalent modification of protein |
| US8623857B2 (en) | 2010-05-26 | 2014-01-07 | Merck Sharp & Dohme Corp. | N-phenyl imidazole carboxamide inhibitors of 3-phosphoinositide-dependent protein kinase-1 |
| EP2865757A1 (de) | 2013-10-22 | 2015-04-29 | Sylentis, S.A.U. | siRNA und deren Verwendung in Verfahren und Zusammensetzungen zur Hemmung der Expression des PDK1-Gens |
| JP6709273B2 (ja) * | 2018-03-28 | 2020-06-10 | 公益財団法人福岡県産業・科学技術振興財団 | 蒸着装置 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5854992A (en) * | 1996-09-26 | 1998-12-29 | President And Fellows Of Harvard College | System and method for structure-based drug design that includes accurate prediction of binding free energy |
| EP0983363B1 (de) * | 1997-03-17 | 2005-11-23 | Medical Research Council | Phosphatidyl-3,4,5-triphosphat abhängige proteinkinase |
| WO2000036135A2 (en) | 1998-12-14 | 2000-06-22 | Medical Research Council | Screening methods based on the use of protein kinases |
| ATE373676T1 (de) | 1998-12-14 | 2007-10-15 | Univ Dundee | Verfahren zur aktivierung von sgk durch phosphorylierung. |
| US6387641B1 (en) * | 1998-12-16 | 2002-05-14 | Vertex Pharmaceuticals Incorporated | Crystallized P38 complexes |
| GB9906245D0 (en) * | 1999-03-19 | 1999-05-12 | Medical Res Council | Enzyme |
| WO2000070030A1 (en) * | 1999-05-19 | 2000-11-23 | Amgen Inc. | Crystal of a lymphocyte kinase-ligand complex and methods of use |
| US6670167B1 (en) | 1999-11-01 | 2003-12-30 | Agouron Pharmaceuticals, Inc. | Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof |
| WO2001035316A2 (en) * | 1999-11-10 | 2001-05-17 | Structural Bioinformatics, Inc. | Computationally derived protein structures in pharmacogenomics |
| WO2001044497A2 (en) | 1999-12-02 | 2001-06-21 | University Of Dundee | Protein kinase regulation |
| EP1272839A4 (de) * | 2000-03-23 | 2006-03-01 | California Inst Of Techn | Verfahren und vorrichtung zum vorhersagen von interaktionen bei der ligandenbindung |
| US6484103B1 (en) * | 2000-09-11 | 2002-11-19 | Astex Technology Limited | Crystal structure |
| US20040137518A1 (en) * | 2002-01-31 | 2004-07-15 | Lambert Millard Hurst | CRYSTALLIZED PPARa LIGAND BINDING DOMAIN POLYPEPTIDE AND SCREENING METHODS EMPLOYING SAME |
-
2002
- 2002-06-08 GB GBGB0213186.0A patent/GB0213186D0/en not_active Ceased
-
2003
- 2003-06-09 EP EP03730356A patent/EP1513947B1/de not_active Expired - Lifetime
- 2003-06-09 WO PCT/GB2003/002509 patent/WO2003104481A2/en active IP Right Grant
- 2003-06-09 AT AT03730356T patent/ATE362993T1/de not_active IP Right Cessation
- 2003-06-09 DE DE60313967T patent/DE60313967T2/de not_active Expired - Lifetime
- 2003-06-09 AU AU2003241038A patent/AU2003241038A1/en not_active Abandoned
- 2003-06-09 US US10/517,225 patent/US7792665B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1513947A2 (de) | 2005-03-16 |
| AU2003241038A8 (en) | 2003-12-22 |
| US20050232804A1 (en) | 2005-10-20 |
| WO2003104481A2 (en) | 2003-12-18 |
| DE60313967T2 (de) | 2008-01-17 |
| WO2003104481A3 (en) | 2004-09-23 |
| AU2003241038A1 (en) | 2003-12-22 |
| ATE362993T1 (de) | 2007-06-15 |
| GB0213186D0 (en) | 2002-07-17 |
| EP1513947B1 (de) | 2007-05-23 |
| US7792665B2 (en) | 2010-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |