DE60307477D1 - Verfahren und vorrichtung zur herstellung von kontrastmitteln für magnetresonanzbildgebung - Google Patents

Verfahren und vorrichtung zur herstellung von kontrastmitteln für magnetresonanzbildgebung

Info

Publication number
DE60307477D1
DE60307477D1 DE60307477T DE60307477T DE60307477D1 DE 60307477 D1 DE60307477 D1 DE 60307477D1 DE 60307477 T DE60307477 T DE 60307477T DE 60307477 T DE60307477 T DE 60307477T DE 60307477 D1 DE60307477 D1 DE 60307477D1
Authority
DE
Germany
Prior art keywords
sub
magnetic resonance
contrast agent
resonance imaging
magnetic field
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60307477T
Other languages
English (en)
Other versions
DE60307477T2 (de
Inventor
Maurice Goldman
Ge Axelsson
Haukur Johannesson
J Ardenkjaer-Larsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of DE60307477D1 publication Critical patent/DE60307477D1/de
Application granted granted Critical
Publication of DE60307477T2 publication Critical patent/DE60307477T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE60307477T 2002-08-29 2003-08-29 Verfahren und vorrichtung zur herstellung von kontrastmitteln für magnetresonanzbildgebung Expired - Lifetime DE60307477T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0219954 2002-08-29
GBGB0219954.5A GB0219954D0 (en) 2002-08-29 2002-08-29 Method and apparatus for producing contrast agents for magnetic resonance imaging
PCT/EP2003/009587 WO2004019995A2 (en) 2002-08-29 2003-08-29 Method and apparatus for producing contrast agents for magnetic resonance imaging

Publications (2)

Publication Number Publication Date
DE60307477D1 true DE60307477D1 (de) 2006-09-21
DE60307477T2 DE60307477T2 (de) 2007-03-29

Family

ID=9943072

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60307477T Expired - Lifetime DE60307477T2 (de) 2002-08-29 2003-08-29 Verfahren und vorrichtung zur herstellung von kontrastmitteln für magnetresonanzbildgebung

Country Status (9)

Country Link
US (1) US20060127313A1 (de)
EP (1) EP1531871B1 (de)
JP (1) JP2006510585A (de)
CN (1) CN100335139C (de)
AT (1) ATE335514T1 (de)
AU (1) AU2003258687A1 (de)
DE (1) DE60307477T2 (de)
GB (1) GB0219954D0 (de)
WO (1) WO2004019995A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1933884B1 (de) * 2005-10-11 2017-09-06 Huntington Medical Research Institutes Abbildungswirkstoffe und verfahren zu ihrer verwendung
WO2008086534A1 (en) * 2007-01-11 2008-07-17 Huntington Medical Research Institutes Imaging agents and methods of use thereof
GB2450316A (en) * 2007-06-18 2008-12-24 Univ York Hyperpolarizing nuclei
US20100233089A1 (en) * 2007-10-05 2010-09-16 Huntington Medical Research Institutes Imaging of genetic material with magnetic resonance
WO2009129265A1 (en) * 2008-04-14 2009-10-22 Huntington Medical Research Institutes Methods and apparatus for pasadena hyperpolarization
EP2374016B1 (de) 2008-12-10 2017-05-10 University of York Impulssequenzierung mit hyperpolarisierbaren kernen
US9452409B2 (en) * 2011-04-22 2016-09-27 Vanderbilt University Para-hydrogen polarizer
US9329246B2 (en) 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
CN103837561A (zh) * 2014-03-11 2014-06-04 吴仁华 一种双量子滤波技术检测脑内γ-氨基丁酸的方法
JP6791760B2 (ja) * 2014-03-14 2020-11-25 ザ ジェネラル ホスピタル コーポレイション 低磁場マルチチャネル撮像のためのシステムおよび方法
CN103941205B (zh) * 2014-05-06 2016-09-14 厦门大学 一种不均匀场下改善核磁共振氢谱分辨率的方法
US9702946B1 (en) * 2014-05-12 2017-07-11 Konstantin Saprygin Creation of long-lived singlet states of gases and their use as inhalable MRI contrast agents
MX2017014426A (es) * 2015-05-12 2018-04-10 Hyperfine Res Inc Metodos y aparatos de bobina de radiofrecuencia.
EP3497457B1 (de) * 2016-08-09 2021-10-06 Beth Israel Deaconess Medical Center, Inc. System und verfahren für die parawasserstoffproduktion
US11684306B2 (en) * 2016-10-28 2023-06-27 THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES et al. Stable water isotope labeling and magnetic resonance imaging for visualization of the presence of and prediction of the likelihood of occurence of rapidly dividing cells
CN108107391B (zh) * 2017-12-18 2019-08-13 厦门大学 一种单体素定域一维高分辨同核去耦谱方法
JP7408351B2 (ja) * 2019-11-06 2024-01-05 キヤノンメディカルシステムズ株式会社 磁気共鳴イメージング装置
DE102020200013A1 (de) * 2020-01-03 2021-07-08 Siemens Healthcare Gmbh Magnetresonanzeinrichtung und Verfahren zum Betrieb einer Magnetresonanzeinrichtung, Computerprogramm und elektronisch lesbarer Datenträger

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4543529A (en) * 1983-01-04 1985-09-24 Nmr Imaging, Inc. Method of tuning an NMR apparatus
US5432446A (en) * 1992-11-02 1995-07-11 Schlumberger Technology Corporation Borehole measurement of NMR characteristics of earth formation
US6311093B1 (en) * 1997-06-20 2001-10-30 Peter G. Brown System and method for simulation, modeling and scheduling of equipment maintenance and calibration in biopharmaceutical batch process manufacturing facilities
CA2294428A1 (en) * 1997-06-20 1998-12-30 Peter G. Brown System and method for simulation, modeling and scheduling of biopharmaceutical batch process operations
AU1047399A (en) * 1997-11-12 1999-05-31 Nycomed Imaging As Para-hydrogen labelled agents and their use in magnetic resonance imaging
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
GB9911681D0 (en) * 1999-05-19 1999-07-21 Nycomed Imaging As Process

Also Published As

Publication number Publication date
WO2004019995A2 (en) 2004-03-11
WO2004019995A3 (en) 2004-05-13
CN1694730A (zh) 2005-11-09
CN100335139C (zh) 2007-09-05
AU2003258687A1 (en) 2004-03-19
AU2003258687A8 (en) 2004-03-19
ATE335514T1 (de) 2006-09-15
EP1531871B1 (de) 2006-08-09
EP1531871A2 (de) 2005-05-25
US20060127313A1 (en) 2006-06-15
JP2006510585A (ja) 2006-03-30
DE60307477T2 (de) 2007-03-29
GB0219954D0 (en) 2002-10-02

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: GOLDMAN, MAURICE, 91140 VILLEBON SUR YVETTE, FR

Inventor name: AXELSSON, OSKAR, GE HEALTHCARE AS, 0401 OSLO, SE

Inventor name: JOHANNESSON, HAUKUR, AMERSHAM HEALTH (R & D) AB, S

Inventor name: ARDENKJAER-LARSEN, J., AMERSHAM HEALTH (R & D) AB,

8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS LLP, LONDON, GB