DE60303504D1 - Verfahren und vorrichtung zur kontaktlosen tröpfchenabgabe unterhalb einer fluidischen oberfläche - Google Patents

Verfahren und vorrichtung zur kontaktlosen tröpfchenabgabe unterhalb einer fluidischen oberfläche

Info

Publication number
DE60303504D1
DE60303504D1 DE60303504T DE60303504T DE60303504D1 DE 60303504 D1 DE60303504 D1 DE 60303504D1 DE 60303504 T DE60303504 T DE 60303504T DE 60303504 T DE60303504 T DE 60303504T DE 60303504 D1 DE60303504 D1 DE 60303504D1
Authority
DE
Germany
Prior art keywords
reagents
dispensing
contactless
another advantage
droplets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60303504T
Other languages
English (en)
Other versions
DE60303504T2 (de
Inventor
C Tisone
John Morrison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biodot Inc
Original Assignee
Biodot Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biodot Inc filed Critical Biodot Inc
Application granted granted Critical
Publication of DE60303504D1 publication Critical patent/DE60303504D1/de
Publication of DE60303504T2 publication Critical patent/DE60303504T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0265—Drop counters; Drop formers using valves to interrupt or meter fluid flow, e.g. using solenoids or metering valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/0036—Nozzles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezoelectric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Manufacture Of Switches (AREA)
  • Sampling And Sample Adjustment (AREA)
DE60303504T 2002-02-22 2003-02-24 Verfahren und vorrichtung zur kontaktlosen tröpfchenabgabe unterhalb einer fluidischen oberfläche Expired - Lifetime DE60303504T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35947102P 2002-02-22 2002-02-22
US359471P 2002-02-22
PCT/US2003/005569 WO2003072258A1 (en) 2002-02-22 2003-02-24 Method and apparatus for dispersing reagent droplets below a fluid surface using non-contact dispensing

Publications (2)

Publication Number Publication Date
DE60303504D1 true DE60303504D1 (de) 2006-04-20
DE60303504T2 DE60303504T2 (de) 2006-10-12

Family

ID=27766093

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60303504T Expired - Lifetime DE60303504T2 (de) 2002-02-22 2003-02-24 Verfahren und vorrichtung zur kontaktlosen tröpfchenabgabe unterhalb einer fluidischen oberfläche

Country Status (5)

Country Link
EP (1) EP1485204B1 (de)
AT (1) ATE317300T1 (de)
AU (1) AU2003219870A1 (de)
DE (1) DE60303504T2 (de)
WO (1) WO2003072258A1 (de)

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US7754439B2 (en) 2003-06-12 2010-07-13 Accupath Diagnostic Laboratories, Inc. Method and system for the analysis of high density cells samples
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US7651665B2 (en) 2004-09-07 2010-01-26 Hewlett-Packard Development Company, L.P. Microtray for handling biosubstances
US7556776B2 (en) 2005-09-08 2009-07-07 President And Fellows Of Harvard College Microfluidic manipulation of fluids and reactions
EP2136911A2 (de) 2007-01-19 2009-12-30 Biodot, Inc. Systeme und verfahren für hochgeschwindigkeitsarraydruck und -hybridisierung
WO2008137213A1 (en) 2007-05-02 2008-11-13 Siemens Healthcare Diagnostics Inc. Piezo dispensing of a diagnostic liquid onto a reagent surface
WO2008137212A1 (en) 2007-05-02 2008-11-13 Siemens Healthcare Diagnostics Inc. Piezo dispensing of a diagnostic liquid into microfluidic devices
TWI537203B (zh) * 2007-11-27 2016-06-11 惠普研發公司 製備滴定系列之技術
WO2009134395A2 (en) 2008-04-28 2009-11-05 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
WO2010014233A1 (en) * 2008-08-01 2010-02-04 President And Fellows Of Harvard College Systems and methods for bubble and/or foam inhibition
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US9598725B2 (en) 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
WO2011120020A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet transport system for detection
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
WO2011120024A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet generation for droplet-based assays
EP2473618B1 (de) 2009-09-02 2015-03-04 Bio-Rad Laboratories, Inc. System zum mischen von flüssigkeiten durch gerinnung mehrerer emulsionen
US8352089B2 (en) * 2010-03-31 2013-01-08 Fishman Corporation Remotely controlled fluid dispenser
DE202010005211U1 (de) 2010-04-15 2011-10-21 Planatol System Gmbh Auftragsystem für flüssige Medien
CA2808118C (en) 2010-07-22 2016-04-19 Kieran Curran Composite liquid cells
EP2635840B1 (de) 2010-11-01 2017-01-04 Bio-Rad Laboratories, Inc. System zur formung von emulsionen
CN103429348B (zh) 2011-01-21 2016-03-09 拜奥－多特公司 具有纵向变换器和可替换毛细管的压电分配器
CA2830443C (en) 2011-03-18 2021-11-16 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
EP3789498A1 (de) 2011-04-25 2021-03-10 Bio-rad Laboratories, Inc. Verfahren zur nukleinsäureanalyse
EP2807255B1 (de) 2012-01-25 2017-08-02 Gencell Biosystems Limited Biomolekülisolierung
WO2013155531A2 (en) 2012-04-13 2013-10-17 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
WO2014074456A1 (en) 2012-11-06 2014-05-15 Biodot, Inc. Controlled printing of a cell sample for karyotyping
CN104812492A (zh) 2012-11-27 2015-07-29 基因细胞生物系统有限公司 处理液体样品
EP2899528B2 (de) * 2014-01-24 2023-05-17 Krüss GmbH Kontaktwinkelmessvorrichtung
EP3105326A4 (de) 2014-02-10 2018-01-10 Gencell Biosystems Limited Vorrichtung zur herstellung einer clc-vermittelten nukleinsäurenbibliothek und verfahren zur verwendung davon
US20180080925A1 (en) * 2015-04-01 2018-03-22 President And Fellows Of Harvard College Respiration device for analysis of a response to shear stress and foreign agents on cells
EP3286543B1 (de) 2015-04-20 2023-03-29 Ventana Medical Systems, Inc. Tintenstrahlmarkierung von reagenzien für histologische proben
EP3529584A1 (de) 2016-10-19 2019-08-28 H. Hoffnabb-La Roche Ag Systeme und verfahren zur färbung von biologischen proben
DE102016015700A1 (de) * 2016-12-21 2018-06-21 Bayer Pharma Aktiengesellschaft Dosiervorrichtung
US11061045B2 (en) 2019-03-12 2021-07-13 Picodya Technologies Ltd. Sample analysis system and method
KR102694067B1 (ko) * 2021-09-24 2024-08-12 한국표준과학연구원 비연속식 유량 측정을 위한 열식 질량 유량계
GB2625086A (en) * 2022-12-05 2024-06-12 Thermo Fisher Scient Bremen Gmbh Liquid transfer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6521187B1 (en) * 1996-05-31 2003-02-18 Packard Instrument Company Dispensing liquid drops onto porous brittle substrates

Also Published As

Publication number Publication date
EP1485204A1 (de) 2004-12-15
ATE317300T1 (de) 2006-02-15
WO2003072258A1 (en) 2003-09-04
AU2003219870A1 (en) 2003-09-09
DE60303504T2 (de) 2006-10-12
EP1485204B1 (de) 2006-02-08

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