DE60303504D1 - Verfahren und vorrichtung zur kontaktlosen tröpfchenabgabe unterhalb einer fluidischen oberfläche - Google Patents
Verfahren und vorrichtung zur kontaktlosen tröpfchenabgabe unterhalb einer fluidischen oberflächeInfo
- Publication number
- DE60303504D1 DE60303504D1 DE60303504T DE60303504T DE60303504D1 DE 60303504 D1 DE60303504 D1 DE 60303504D1 DE 60303504 T DE60303504 T DE 60303504T DE 60303504 T DE60303504 T DE 60303504T DE 60303504 D1 DE60303504 D1 DE 60303504D1
- Authority
- DE
- Germany
- Prior art keywords
- reagents
- dispensing
- contactless
- another advantage
- droplets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000010926 purge Methods 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 3
- 239000012530 fluid Substances 0.000 abstract 3
- 238000003556 assay Methods 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0241—Drop counters; Drop formers
- B01L3/0265—Drop counters; Drop formers using valves to interrupt or meter fluid flow, e.g. using solenoids or metering valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/0036—Nozzles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00378—Piezoelectric or ink jet dispensers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/142—Preventing evaporation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
- B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Manufacture Of Switches (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35947102P | 2002-02-22 | 2002-02-22 | |
US359471P | 2002-02-22 | ||
PCT/US2003/005569 WO2003072258A1 (en) | 2002-02-22 | 2003-02-24 | Method and apparatus for dispersing reagent droplets below a fluid surface using non-contact dispensing |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60303504D1 true DE60303504D1 (de) | 2006-04-20 |
DE60303504T2 DE60303504T2 (de) | 2006-10-12 |
Family
ID=27766093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60303504T Expired - Lifetime DE60303504T2 (de) | 2002-02-22 | 2003-02-24 | Verfahren und vorrichtung zur kontaktlosen tröpfchenabgabe unterhalb einer fluidischen oberfläche |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1485204B1 (de) |
AT (1) | ATE317300T1 (de) |
AU (1) | AU2003219870A1 (de) |
DE (1) | DE60303504T2 (de) |
WO (1) | WO2003072258A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7754439B2 (en) | 2003-06-12 | 2010-07-13 | Accupath Diagnostic Laboratories, Inc. | Method and system for the analysis of high density cells samples |
US7041481B2 (en) | 2003-03-14 | 2006-05-09 | The Regents Of The University Of California | Chemical amplification based on fluid partitioning |
US7651665B2 (en) | 2004-09-07 | 2010-01-26 | Hewlett-Packard Development Company, L.P. | Microtray for handling biosubstances |
US7556776B2 (en) | 2005-09-08 | 2009-07-07 | President And Fellows Of Harvard College | Microfluidic manipulation of fluids and reactions |
EP2136911A2 (de) | 2007-01-19 | 2009-12-30 | Biodot, Inc. | Systeme und verfahren für hochgeschwindigkeitsarraydruck und -hybridisierung |
WO2008137213A1 (en) | 2007-05-02 | 2008-11-13 | Siemens Healthcare Diagnostics Inc. | Piezo dispensing of a diagnostic liquid onto a reagent surface |
WO2008137212A1 (en) | 2007-05-02 | 2008-11-13 | Siemens Healthcare Diagnostics Inc. | Piezo dispensing of a diagnostic liquid into microfluidic devices |
TWI537203B (zh) * | 2007-11-27 | 2016-06-11 | 惠普研發公司 | 製備滴定系列之技術 |
WO2009134395A2 (en) | 2008-04-28 | 2009-11-05 | President And Fellows Of Harvard College | Microfluidic device for storage and well-defined arrangement of droplets |
WO2010014233A1 (en) * | 2008-08-01 | 2010-02-04 | President And Fellows Of Harvard College | Systems and methods for bubble and/or foam inhibition |
US9492797B2 (en) | 2008-09-23 | 2016-11-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
US8951939B2 (en) | 2011-07-12 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Digital assays with multiplexed detection of two or more targets in the same optical channel |
US10512910B2 (en) | 2008-09-23 | 2019-12-24 | Bio-Rad Laboratories, Inc. | Droplet-based analysis method |
US9598725B2 (en) | 2010-03-02 | 2017-03-21 | Bio-Rad Laboratories, Inc. | Emulsion chemistry for encapsulated droplets |
US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
US9417190B2 (en) | 2008-09-23 | 2016-08-16 | Bio-Rad Laboratories, Inc. | Calibrations and controls for droplet-based assays |
WO2011120020A1 (en) | 2010-03-25 | 2011-09-29 | Quantalife, Inc. | Droplet transport system for detection |
US9764322B2 (en) | 2008-09-23 | 2017-09-19 | Bio-Rad Laboratories, Inc. | System for generating droplets with pressure monitoring |
US9132394B2 (en) | 2008-09-23 | 2015-09-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
US11130128B2 (en) | 2008-09-23 | 2021-09-28 | Bio-Rad Laboratories, Inc. | Detection method for a target nucleic acid |
WO2011120024A1 (en) | 2010-03-25 | 2011-09-29 | Quantalife, Inc. | Droplet generation for droplet-based assays |
EP2473618B1 (de) | 2009-09-02 | 2015-03-04 | Bio-Rad Laboratories, Inc. | System zum mischen von flüssigkeiten durch gerinnung mehrerer emulsionen |
US8352089B2 (en) * | 2010-03-31 | 2013-01-08 | Fishman Corporation | Remotely controlled fluid dispenser |
DE202010005211U1 (de) | 2010-04-15 | 2011-10-21 | Planatol System Gmbh | Auftragsystem für flüssige Medien |
CA2808118C (en) | 2010-07-22 | 2016-04-19 | Kieran Curran | Composite liquid cells |
EP2635840B1 (de) | 2010-11-01 | 2017-01-04 | Bio-Rad Laboratories, Inc. | System zur formung von emulsionen |
CN103429348B (zh) | 2011-01-21 | 2016-03-09 | 拜奥-多特公司 | 具有纵向变换器和可替换毛细管的压电分配器 |
CA2830443C (en) | 2011-03-18 | 2021-11-16 | Bio-Rad Laboratories, Inc. | Multiplexed digital assays with combinatorial use of signals |
EP3789498A1 (de) | 2011-04-25 | 2021-03-10 | Bio-rad Laboratories, Inc. | Verfahren zur nukleinsäureanalyse |
EP2807255B1 (de) | 2012-01-25 | 2017-08-02 | Gencell Biosystems Limited | Biomolekülisolierung |
WO2013155531A2 (en) | 2012-04-13 | 2013-10-17 | Bio-Rad Laboratories, Inc. | Sample holder with a well having a wicking promoter |
WO2014074456A1 (en) | 2012-11-06 | 2014-05-15 | Biodot, Inc. | Controlled printing of a cell sample for karyotyping |
CN104812492A (zh) | 2012-11-27 | 2015-07-29 | 基因细胞生物系统有限公司 | 处理液体样品 |
EP2899528B2 (de) * | 2014-01-24 | 2023-05-17 | Krüss GmbH | Kontaktwinkelmessvorrichtung |
EP3105326A4 (de) | 2014-02-10 | 2018-01-10 | Gencell Biosystems Limited | Vorrichtung zur herstellung einer clc-vermittelten nukleinsäurenbibliothek und verfahren zur verwendung davon |
US20180080925A1 (en) * | 2015-04-01 | 2018-03-22 | President And Fellows Of Harvard College | Respiration device for analysis of a response to shear stress and foreign agents on cells |
EP3286543B1 (de) | 2015-04-20 | 2023-03-29 | Ventana Medical Systems, Inc. | Tintenstrahlmarkierung von reagenzien für histologische proben |
EP3529584A1 (de) | 2016-10-19 | 2019-08-28 | H. Hoffnabb-La Roche Ag | Systeme und verfahren zur färbung von biologischen proben |
DE102016015700A1 (de) * | 2016-12-21 | 2018-06-21 | Bayer Pharma Aktiengesellschaft | Dosiervorrichtung |
US11061045B2 (en) | 2019-03-12 | 2021-07-13 | Picodya Technologies Ltd. | Sample analysis system and method |
KR102694067B1 (ko) * | 2021-09-24 | 2024-08-12 | 한국표준과학연구원 | 비연속식 유량 측정을 위한 열식 질량 유량계 |
GB2625086A (en) * | 2022-12-05 | 2024-06-12 | Thermo Fisher Scient Bremen Gmbh | Liquid transfer |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6521187B1 (en) * | 1996-05-31 | 2003-02-18 | Packard Instrument Company | Dispensing liquid drops onto porous brittle substrates |
-
2003
- 2003-02-24 AU AU2003219870A patent/AU2003219870A1/en not_active Abandoned
- 2003-02-24 AT AT03716153T patent/ATE317300T1/de not_active IP Right Cessation
- 2003-02-24 WO PCT/US2003/005569 patent/WO2003072258A1/en not_active Application Discontinuation
- 2003-02-24 DE DE60303504T patent/DE60303504T2/de not_active Expired - Lifetime
- 2003-02-24 EP EP03716153A patent/EP1485204B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1485204A1 (de) | 2004-12-15 |
ATE317300T1 (de) | 2006-02-15 |
WO2003072258A1 (en) | 2003-09-04 |
AU2003219870A1 (en) | 2003-09-09 |
DE60303504T2 (de) | 2006-10-12 |
EP1485204B1 (de) | 2006-02-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60303504D1 (de) | Verfahren und vorrichtung zur kontaktlosen tröpfchenabgabe unterhalb einer fluidischen oberfläche | |
CA2555060C (en) | Method and device for manipulating liquids in microfluidic systems | |
HK1127066A1 (en) | Droplet-based biochemistry | |
US6660527B2 (en) | Fluid-transfer collection assembly and method of using the same | |
EP2364774A3 (de) | Mikrofluidische Vorrichtungen Und Verfahren Zur Verwendung Bei Der Bildung Und Kontrolle Von Nanoreaktoren | |
EP1385006A3 (de) | System und Patrone zur Verarbeitung einer biologischen Probe | |
DE60035316D1 (de) | Vorrichtung und verfahren zur detektion von analyten in flüssigkeiten | |
WO2008002483A3 (en) | Reagent preparation and valving design for liquid testing | |
WO2005091993A3 (en) | Device for aspirating, manipulating, mixing and dispensing nano-volumes of liquids | |
WO2007103969A3 (en) | Fluidic system for a flow cytometer | |
DE60212614D1 (de) | Vorrichtung zur dosierung von reagenzien | |
WO2006014460A3 (en) | Spotting device and method for high concentration spot deposition on microarrays and other microscale devices | |
WO2002047820A8 (en) | Non-contact fluid transfer methods, apparatus and uses thereof | |
WO2008028160A3 (en) | Substrates, systems and methods for analyzing materials | |
ATE540750T1 (de) | Mikrofluidische vorrichtung und verfahren | |
WO2001043871A3 (en) | Microarray hybridization chamber | |
ATE461751T1 (de) | Verfahren und vorrichtung zur abgabe von flüssigen mehrkomponenten-substanzen | |
DE69906346D1 (de) | Gerät zum dekantieren und/oder belüften von flüssigkeiten | |
WO2004103565A3 (de) | Vorrichtung und verfahren zur strukturierung von flüssigkeiten und zum zudosieren von reaktionsflüssigkeiten zu in separationsmedium eingebetteten flüssigkeitskompartimenten | |
DE60014676D1 (de) | Vorrichtung und verfahren zur analyse flüssiger proben | |
WO2008024319A8 (en) | Microfluidic devices for nucleic acid assembly | |
CN102839111A (zh) | 分注方法 | |
BR0101443A (pt) | Instalação de transferência de um gás em umlìquido | |
WO2004038367A3 (en) | Biological assays using gradients formed in microfluidic systems | |
DE60116794D1 (de) | Schallausstoss von fluiden aus mehreren behältern |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |