DE60238666D1 - Cyclohexenon derivate zur behandlung der diabetischen neuropathie - Google Patents

Cyclohexenon derivate zur behandlung der diabetischen neuropathie

Info

Publication number
DE60238666D1
DE60238666D1 DE60238666T DE60238666T DE60238666D1 DE 60238666 D1 DE60238666 D1 DE 60238666D1 DE 60238666 T DE60238666 T DE 60238666T DE 60238666 T DE60238666 T DE 60238666T DE 60238666 D1 DE60238666 D1 DE 60238666D1
Authority
DE
Germany
Prior art keywords
diabetic neuropathy
treatment
preventive
therapeutic agent
diabetes complications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60238666T
Other languages
German (de)
English (en)
Inventor
Masao Miyagawa
Takeshi Watanabe
Motoaki Saito
Bang Luu
Masashi Yamada
Hiroto Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite de Strasbourg
Meiji Co Ltd
Original Assignee
Meiji Dairies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Dairies Corp filed Critical Meiji Dairies Corp
Application granted granted Critical
Publication of DE60238666D1 publication Critical patent/DE60238666D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60238666T 2001-02-19 2002-02-15 Cyclohexenon derivate zur behandlung der diabetischen neuropathie Expired - Lifetime DE60238666D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001041586A JP4861560B2 (ja) 2001-02-19 2001-02-19 糖尿病合併症治療剤
PCT/JP2002/001291 WO2002066023A1 (en) 2001-02-19 2002-02-15 Use of a cyclohexenone derivatives in the manufacture of a medicament for treating diabetic complications

Publications (1)

Publication Number Publication Date
DE60238666D1 true DE60238666D1 (de) 2011-02-03

Family

ID=18904008

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60238666T Expired - Lifetime DE60238666D1 (de) 2001-02-19 2002-02-15 Cyclohexenon derivate zur behandlung der diabetischen neuropathie

Country Status (8)

Country Link
US (1) US7838565B2 (https=)
EP (1) EP1368013B1 (https=)
JP (1) JP4861560B2 (https=)
AT (1) ATE492274T1 (https=)
CA (1) CA2438506C (https=)
DE (1) DE60238666D1 (https=)
ES (1) ES2355891T3 (https=)
WO (1) WO2002066023A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004087630A1 (en) * 2003-03-28 2004-10-14 Meiji Dairies Corporation Process for producing cyclohexenone long-chain alcohols
EP1829536B1 (en) * 2004-11-25 2011-03-30 Meiji Dairies Corporation Ameliorant for renal insufficiency
DE602006014799D1 (de) * 2005-01-18 2010-07-22 Meiji Dairies Corp Heilmittel gegen sensorische erkrankungen
JP4986505B2 (ja) * 2005-05-26 2012-07-25 株式会社明治 糖尿病性血管障害および呼吸障害予防および／または治療剤
CA2609595C (en) * 2005-05-26 2013-01-08 Meiji Dairies Corporation Preventive and/or therapeutic agents for diabetic vascular disorders and respiratory disorders
US8309611B2 (en) * 2010-09-20 2012-11-13 Golden Biotechnology Corporation Methods and compositions for treating lung cancer
CA2800329A1 (en) * 2011-12-30 2013-06-30 Golden Biotechnology Corporation Methods and compositions for treating diabetes
EP3406586B1 (en) 2016-01-22 2020-12-30 Taiho Pharmaceutical Co., Ltd. Manufacturing method for high-purity cyclohexenone long-chain alcohol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0555149B1 (en) 1992-02-07 1997-08-27 Mitsubishi Gas Chemical Company, Inc. Use of oxazopyrroloquinolines and pyrroloquinolinequinones for the manufacture of nerve growth factor production accelerators
US6113947A (en) * 1997-06-13 2000-09-05 Genentech, Inc. Controlled release microencapsulated NGF formulation
EP1003706B1 (en) * 1997-08-13 2003-03-05 Meiji Milk Products Company Limited Cyclohexenone long-chain alcohol and medicament containing same
JP4469441B2 (ja) 1999-02-10 2010-05-26 明治乳業株式会社 神経変性疾患の予防又は治療薬
ATE450602T1 (de) * 2000-10-04 2009-12-15 Meiji Dairies Corp Stemzelldifferenzierung induzierende promoter
JP3836684B2 (ja) * 2001-02-19 2006-10-25 明治乳業株式会社 排尿障害治療剤
US20040152786A1 (en) * 2001-05-24 2004-08-05 Bang Luu Preventive or remedy for diseases caused by cerebrovascular disturbances

Also Published As

Publication number Publication date
JP2002241270A (ja) 2002-08-28
ATE492274T1 (de) 2011-01-15
US20040102527A1 (en) 2004-05-27
US7838565B2 (en) 2010-11-23
EP1368013A1 (en) 2003-12-10
ES2355891T3 (es) 2011-04-01
CA2438506C (en) 2010-04-20
CA2438506A1 (en) 2002-08-29
JP4861560B2 (ja) 2012-01-25
WO2002066023A1 (en) 2002-08-29
EP1368013B1 (en) 2010-12-22

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