DE60236939D1 - Hemmung der neurodegeneration - Google Patents
Hemmung der neurodegenerationInfo
- Publication number
- DE60236939D1 DE60236939D1 DE60236939T DE60236939T DE60236939D1 DE 60236939 D1 DE60236939 D1 DE 60236939D1 DE 60236939 T DE60236939 T DE 60236939T DE 60236939 T DE60236939 T DE 60236939T DE 60236939 D1 DE60236939 D1 DE 60236939D1
- Authority
- DE
- Germany
- Prior art keywords
- neurodegeneration
- inhibition
- disease
- alzheimer
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000004770 neurodegeneration Effects 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000014509 gene expression Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000016273 neuron death Effects 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 238000012301 transgenic model Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Neurology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Environmental Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/872,968 US6770797B2 (en) | 2001-06-01 | 2001-06-01 | Non-Transgenic nonhuman model for Alzheimer's Disease using a AD7c-NTP nucleic acid |
PCT/US2002/016429 WO2002099036A2 (en) | 2001-06-01 | 2002-05-28 | Inhibition of neurodegeneration |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60236939D1 true DE60236939D1 (de) | 2010-08-19 |
Family
ID=25360708
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60236939T Expired - Lifetime DE60236939D1 (de) | 2001-06-01 | 2002-05-28 | Hemmung der neurodegeneration |
Country Status (8)
Country | Link |
---|---|
US (2) | US6770797B2 (de) |
EP (1) | EP1414478B1 (de) |
JP (1) | JP2005516886A (de) |
AT (1) | ATE473009T1 (de) |
AU (1) | AU2002312033B2 (de) |
CA (1) | CA2448863C (de) |
DE (1) | DE60236939D1 (de) |
WO (1) | WO2002099036A2 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60223524D1 (de) * | 2001-05-04 | 2007-12-27 | Nymox Corp | Verfahren zur vorbeugung von zelltod unter verwendung von antikörpern gegen neural thread proteine |
JP2005535580A (ja) * | 2002-04-26 | 2005-11-24 | イアン, エイ. ファーガソン, | 血液脳関門を通したポリペプチドの非侵襲的な送達およびエンドサイトーシスリガンドの生体内選択 |
AU2003233120B2 (en) * | 2002-04-26 | 2008-08-21 | Ferguson, Ian Andrew | Non-invasive delivery of polypeptides through the blood-brain barrier, and in vivo selection of endocytotic ligands |
US7544771B2 (en) * | 2005-02-23 | 2009-06-09 | Nymox Corporation | Protein and its use in diagnosing Alzheimer's disease |
EP2381774A4 (de) * | 2008-12-23 | 2012-07-18 | Salk Inst For Biological Studi | Verfahren zur behandlung von neurodegenerativen erkrankungen |
EP2521914A4 (de) * | 2010-01-08 | 2013-07-10 | Oncohealth Corp | Zellbasierte hpv-immuntests mit hoher durchlaufleistung zur diagnose und abtastung von hpv-assoziierten krebsen |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5948634A (en) | 1988-12-21 | 1999-09-07 | The General Hospital Coporation | Neural thread protein gene expression and detection of alzheimer's disease |
CA2109955A1 (en) | 1991-05-24 | 1992-11-26 | Toru Hayakawa | Equipment for intracerebral administration of preparations |
WO1994023756A1 (en) | 1993-04-20 | 1994-10-27 | The General Hospital Corporation | Neural thread protein gene expression and detection of alzheimer's disease |
US5744335A (en) | 1995-09-19 | 1998-04-28 | Mirus Corporation | Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein |
US5863898A (en) | 1996-10-29 | 1999-01-26 | Incyte Pharmaceuticals, Inc. | Human lim proteins |
JP3758792B2 (ja) | 1997-02-25 | 2006-03-22 | 三菱重工業株式会社 | ガスタービン動翼のプラットフォーム冷却機構 |
KR20000075748A (ko) | 1997-02-26 | 2000-12-26 | 마빈 씨. 구트리 | 알츠하이머 병의 치료 또는 예방에 유효한 약물을 선별하기 위한 유전자 변형동물 및 세포계 |
CA2323889A1 (en) | 1997-03-12 | 1998-09-17 | Robert W. Esmond | A method for treating or preventing alzheimer's disease |
-
2001
- 2001-06-01 US US09/872,968 patent/US6770797B2/en not_active Expired - Lifetime
-
2002
- 2002-05-28 EP EP02739383A patent/EP1414478B1/de not_active Expired - Lifetime
- 2002-05-28 JP JP2003502146A patent/JP2005516886A/ja active Pending
- 2002-05-28 AT AT02739383T patent/ATE473009T1/de not_active IP Right Cessation
- 2002-05-28 AU AU2002312033A patent/AU2002312033B2/en not_active Ceased
- 2002-05-28 WO PCT/US2002/016429 patent/WO2002099036A2/en active Application Filing
- 2002-05-28 DE DE60236939T patent/DE60236939D1/de not_active Expired - Lifetime
- 2002-05-28 CA CA2448863A patent/CA2448863C/en not_active Expired - Fee Related
-
2004
- 2004-08-02 US US10/910,173 patent/US7319094B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20030050262A1 (en) | 2003-03-13 |
AU2002312033B2 (en) | 2007-10-18 |
WO2002099036A3 (en) | 2004-01-08 |
EP1414478A4 (de) | 2007-03-21 |
ATE473009T1 (de) | 2010-07-15 |
US7319094B2 (en) | 2008-01-15 |
EP1414478B1 (de) | 2010-07-07 |
CA2448863A1 (en) | 2002-12-12 |
WO2002099036A2 (en) | 2002-12-12 |
EP1414478A2 (de) | 2004-05-06 |
CA2448863C (en) | 2010-05-04 |
JP2005516886A (ja) | 2005-06-09 |
US6770797B2 (en) | 2004-08-03 |
US20050090441A1 (en) | 2005-04-28 |
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