DE60234858D1 - Polyalkylenoxid-Konjugate von thiolhaltigen Arzneistoffen - Google Patents
Polyalkylenoxid-Konjugate von thiolhaltigen ArzneistoffenInfo
- Publication number
- DE60234858D1 DE60234858D1 DE60234858T DE60234858T DE60234858D1 DE 60234858 D1 DE60234858 D1 DE 60234858D1 DE 60234858 T DE60234858 T DE 60234858T DE 60234858 T DE60234858 T DE 60234858T DE 60234858 D1 DE60234858 D1 DE 60234858D1
- Authority
- DE
- Germany
- Prior art keywords
- thiol
- polyalkylene oxide
- containing drugs
- oxide conjugates
- disclosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 125000003396 thiol group Chemical class [H]S* 0.000 title abstract 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
- C08G63/688—Polyesters containing atoms other than carbon, hydrogen and oxygen containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/46—Polyesters chemically modified by esterification
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
- C08G63/685—Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34491401P | 2001-11-09 | 2001-11-09 | |
| US36732002P | 2002-03-25 | 2002-03-25 | |
| PCT/US2002/035868 WO2003039479A2 (en) | 2001-11-09 | 2002-11-08 | Polymeric thiol-linked prodrugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60234858D1 true DE60234858D1 (de) | 2010-02-04 |
Family
ID=26994161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60234858T Expired - Lifetime DE60234858D1 (de) | 2001-11-09 | 2002-11-08 | Polyalkylenoxid-Konjugate von thiolhaltigen Arzneistoffen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7033583B2 (https=) |
| EP (1) | EP1450822B1 (https=) |
| JP (1) | JP2005512991A (https=) |
| AT (1) | ATE452654T1 (https=) |
| AU (1) | AU2002363334A1 (https=) |
| CA (1) | CA2465206C (https=) |
| DE (1) | DE60234858D1 (https=) |
| DK (1) | DK1450822T3 (https=) |
| WO (1) | WO2003039479A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1450844A4 (en) * | 2001-11-09 | 2009-07-29 | Enzon Inc | POLYMER THIOL-LINKED PRODRUGS USING BENZYL ELIMINATION SYSTEMS |
| US7612153B2 (en) * | 2004-10-25 | 2009-11-03 | Intezyne Technologies, Inc. | Heterobifunctional poly(ethylene glycol) and uses thereof |
| CA2650035C (en) | 2006-04-27 | 2015-02-03 | Intezyne Technologies, Inc. | Poly (ethylene glycol) containing chemically disparate endgroups |
| US20100203066A1 (en) * | 2007-08-20 | 2010-08-12 | Enzon Pharmaceuticals, Inc. | Polymeric linkers containing pyridyl disulfide moieties |
| WO2009048780A1 (en) * | 2007-10-08 | 2009-04-16 | The University Of Kentucky Research Foundation | Polymer-metal chelator conjugates and uses thereof |
| WO2009143412A2 (en) * | 2008-05-23 | 2009-11-26 | Enzon Pharmaceuticals, Inc. | Polymeric systems containing intracellular releasable disulfide linker for the delivery of oligonucleotides |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1023376A (en) * | 1972-08-04 | 1977-12-27 | Hermann O. Wirth | Hydrophilic and difficultly volatile biocidal triorganometallic compounds |
| US5112739A (en) * | 1988-08-02 | 1992-05-12 | Polaroid Corporation | Enzyme controlled release system |
| JPH05132431A (ja) * | 1990-03-28 | 1993-05-28 | Nippon Oil & Fats Co Ltd | 高分子化薬剤およびその製造法 |
| US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| JPH05194517A (ja) * | 1992-01-16 | 1993-08-03 | Tanabe Seiyaku Co Ltd | ６−メルカプトプリン誘導体及びその製法 |
| JPH05194518A (ja) * | 1992-01-16 | 1993-08-03 | Tanabe Seiyaku Co Ltd | ６−メルカプトプリン誘導体及びその製法 |
| US5840900A (en) * | 1993-10-20 | 1998-11-24 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| WO1999030727A1 (en) * | 1997-12-17 | 1999-06-24 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| US6251382B1 (en) * | 1998-04-17 | 2001-06-26 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
| US6765019B1 (en) | 1999-05-06 | 2004-07-20 | University Of Kentucky Research Foundation | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
| US6468522B1 (en) * | 1999-07-22 | 2002-10-22 | University Of Medicine And Dentistry Of New Jersey | Controlled release of thioamide moiety-containing therapeutic agents |
| US6376470B1 (en) * | 1999-09-23 | 2002-04-23 | Enzon, Inc. | Polymer conjugates of ara-C and ara-C derivatives |
| EP1450844A4 (en) * | 2001-11-09 | 2009-07-29 | Enzon Inc | POLYMER THIOL-LINKED PRODRUGS USING BENZYL ELIMINATION SYSTEMS |
-
2002
- 2002-11-08 DE DE60234858T patent/DE60234858D1/de not_active Expired - Lifetime
- 2002-11-08 AT AT02798434T patent/ATE452654T1/de not_active IP Right Cessation
- 2002-11-08 DK DK02798434.3T patent/DK1450822T3/da active
- 2002-11-08 JP JP2003541771A patent/JP2005512991A/ja active Pending
- 2002-11-08 AU AU2002363334A patent/AU2002363334A1/en not_active Abandoned
- 2002-11-08 US US10/290,695 patent/US7033583B2/en not_active Expired - Fee Related
- 2002-11-08 EP EP02798434A patent/EP1450822B1/en not_active Expired - Lifetime
- 2002-11-08 WO PCT/US2002/035868 patent/WO2003039479A2/en not_active Ceased
- 2002-11-08 CA CA2465206A patent/CA2465206C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20030147844A1 (en) | 2003-08-07 |
| ATE452654T1 (de) | 2010-01-15 |
| AU2002363334A1 (en) | 2003-05-19 |
| EP1450822A4 (en) | 2006-04-05 |
| WO2003039479A3 (en) | 2003-08-21 |
| WO2003039479A2 (en) | 2003-05-15 |
| EP1450822B1 (en) | 2009-12-23 |
| JP2005512991A (ja) | 2005-05-12 |
| US7033583B2 (en) | 2006-04-25 |
| CA2465206C (en) | 2010-01-26 |
| DK1450822T3 (da) | 2010-04-19 |
| EP1450822A2 (en) | 2004-09-01 |
| CA2465206A1 (en) | 2003-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |