DE60234097D1 - Chimere proteine zum targeting von zellen und der induktion von apoptose, und verfahren zu deren verwendung - Google Patents
Chimere proteine zum targeting von zellen und der induktion von apoptose, und verfahren zu deren verwendungInfo
- Publication number
- DE60234097D1 DE60234097D1 DE60234097T DE60234097T DE60234097D1 DE 60234097 D1 DE60234097 D1 DE 60234097D1 DE 60234097 T DE60234097 T DE 60234097T DE 60234097 T DE60234097 T DE 60234097T DE 60234097 D1 DE60234097 D1 DE 60234097D1
- Authority
- DE
- Germany
- Prior art keywords
- apoptosis
- induction
- chimeric proteins
- targeting cells
- disclosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000008685 targeting Effects 0.000 title abstract 4
- 102000037865 fusion proteins Human genes 0.000 title abstract 3
- 108020001507 fusion proteins Proteins 0.000 title abstract 3
- 230000006882 induction of apoptosis Effects 0.000 title 1
- 102000010565 Apoptosis Regulatory Proteins Human genes 0.000 abstract 1
- 108010063104 Apoptosis Regulatory Proteins Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 230000034994 death Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29379401P | 2001-05-25 | 2001-05-25 | |
| PCT/US2002/016680 WO2002097042A2 (en) | 2001-05-25 | 2002-05-28 | Chimeric proteins for cell targeting and apoptosis induction and methods of using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60234097D1 true DE60234097D1 (de) | 2009-12-03 |
Family
ID=23130607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60234097T Expired - Fee Related DE60234097D1 (de) | 2001-05-25 | 2002-05-28 | Chimere proteine zum targeting von zellen und der induktion von apoptose, und verfahren zu deren verwendung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7592012B2 (de) |
| EP (1) | EP1397386B1 (de) |
| JP (1) | JP2004535415A (de) |
| KR (1) | KR20040014528A (de) |
| CN (1) | CN100497387C (de) |
| AT (1) | ATE446316T1 (de) |
| AU (1) | AU2002314814B2 (de) |
| CA (1) | CA2448100A1 (de) |
| DE (1) | DE60234097D1 (de) |
| WO (1) | WO2002097042A2 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050074865A1 (en) * | 2002-08-27 | 2005-04-07 | Compound Therapeutics, Inc. | Adzymes and uses thereof |
| AU2006347606B2 (en) * | 2005-09-09 | 2012-10-11 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for inhibiting cell death or enhancing cell proliferation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5910486A (en) * | 1994-09-06 | 1999-06-08 | Uab Research Foundation | Methods for modulating protein function in cells using, intracellular antibody homologues |
| AU5965296A (en) * | 1995-05-31 | 1996-12-18 | Regents Of The University Of Minnesota | Recombinant polypeptide cytotoxins for cancer treatment |
| US6645490B2 (en) * | 1998-03-02 | 2003-11-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Chimeric proteins with cell-targeting specificity and apoptosis-inducing activities |
| AU2185199A (en) * | 1998-09-30 | 2000-04-17 | Yoko Aida | Apoptosis inducers |
| US6733994B2 (en) * | 2000-10-04 | 2004-05-11 | The Trustees Of The University Of Pennsylvania | Highly expressible genes |
| US20040028651A1 (en) | 2001-03-29 | 2004-02-12 | Karrupiah Muthumani | Composition and methods of using hiv vpr |
-
2002
- 2002-05-28 WO PCT/US2002/016680 patent/WO2002097042A2/en active Application Filing
- 2002-05-28 CN CNB028076664A patent/CN100497387C/zh not_active Expired - Fee Related
- 2002-05-28 AT AT02741737T patent/ATE446316T1/de not_active IP Right Cessation
- 2002-05-28 AU AU2002314814A patent/AU2002314814B2/en not_active Ceased
- 2002-05-28 EP EP02741737A patent/EP1397386B1/de not_active Expired - Lifetime
- 2002-05-28 CA CA002448100A patent/CA2448100A1/en not_active Abandoned
- 2002-05-28 DE DE60234097T patent/DE60234097D1/de not_active Expired - Fee Related
- 2002-05-28 JP JP2003500211A patent/JP2004535415A/ja active Pending
- 2002-05-28 US US10/478,741 patent/US7592012B2/en active Active
- 2002-05-28 KR KR10-2003-7015343A patent/KR20040014528A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1397386A4 (de) | 2005-01-05 |
| KR20040014528A (ko) | 2004-02-14 |
| WO2002097042A2 (en) | 2002-12-05 |
| ATE446316T1 (de) | 2009-11-15 |
| EP1397386B1 (de) | 2009-10-21 |
| CN100497387C (zh) | 2009-06-10 |
| AU2002314814B2 (en) | 2007-12-20 |
| WO2002097042A3 (en) | 2003-10-23 |
| JP2004535415A (ja) | 2004-11-25 |
| US7592012B2 (en) | 2009-09-22 |
| CN1531552A (zh) | 2004-09-22 |
| EP1397386A2 (de) | 2004-03-17 |
| CA2448100A1 (en) | 2002-12-05 |
| US20040181041A1 (en) | 2004-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2018273986A1 (en) | Bipartite base editor (BBE) architectures and type-II-C-Cas9 zinc finger editing | |
| WO2019139645A3 (en) | High efficiency base editors comprising gam | |
| ATE380878T1 (de) | Verfahren und zusammensetzungen für die proteinexpression und reinigung | |
| DE60325892D1 (de) | Stellungs- und verwendungsverfahren | |
| NZ521396A (en) | Fusion proteins comprising two or more Neisseria polypeptides | |
| NO331271B1 (no) | Fusjonsprotein for sekresjon av et protein av interesse til supernatanten til en bakteriekultur, fremgangsmate, plasmid og vertscelle for fremstilling | |
| DE602005026855D1 (de) | Vorrichtungen und verfahren zur bestimmung von proteaseaktivität | |
| ATE525395T1 (de) | Fusions proteine von glp-1-analoga | |
| ATE517914T1 (de) | Dimere fusionsproteine und materialien und verfahren zu deren herstellung | |
| NO20025402D0 (no) | Modifiserte ES-celler og ES-spesifikt gen | |
| TW200607505A (en) | Fused heterocyclic kinase inhibitors | |
| DK2287288T3 (da) | Medium frit for animalsk protein til dyrkning af celler | |
| ATE510023T1 (de) | Enzyme mit alpha-amylase-aktivität und verfahren zu deren verwendung | |
| WO2005003313A8 (en) | Methods and compositions for enhanced protein expression and purification | |
| DK1641483T3 (da) | Fusionsproteiner | |
| DE602006021520D1 (de) | Rekombinante Polypeptide auf Triplex-Gerüst-Basis | |
| ATE457355T1 (de) | Verfahren und dna-konstrukte zur produktion von polypeptiden mit hoher ausbeute | |
| DE602004026912D1 (de) | Formulierungen und verfahren zum denaturieren von proteinen | |
| DE60230456D1 (de) | Faktor-viii-polypeptide auf hohem expressionsnivea und verwendungsverfahren | |
| WO2003097810A3 (en) | Nitrilases, nucleic acids encoding them and methods for making and using them | |
| WO2002022662A3 (en) | Insect inhibitory bacillus thuringiensis proteins, fusions, and methods of use therefor | |
| DE60139544D1 (de) | Veränderte, fluoreszierende proteine | |
| NO20083609L (no) | Fremgangsmater og sammensetninger for malrettet-RELT | |
| ATE466874T1 (de) | Mit scytovirin der domäne 1 verwandte polypeptide | |
| DK0981601T3 (da) | Fremgangsmåder til dyrkning af celler og opformering af vira |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |