DE60227536D1 - Chemische synthese von solamargin - Google Patents
Chemische synthese von solamarginInfo
- Publication number
- DE60227536D1 DE60227536D1 DE60227536T DE60227536T DE60227536D1 DE 60227536 D1 DE60227536 D1 DE 60227536D1 DE 60227536 T DE60227536 T DE 60227536T DE 60227536 T DE60227536 T DE 60227536T DE 60227536 D1 DE60227536 D1 DE 60227536D1
- Authority
- DE
- Germany
- Prior art keywords
- chemical synthesis
- solamargin
- synthesis
- solamargine
- solanum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
- MBWUSSKCCUMJHO-ZGXDEBHDSA-N Solamargine Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O[C@H]1[C@@H]([C@H](O)[C@@H](O)[C@H](C)O1)O)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@H]5[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@@H]([C@]1(NC[C@H](C)CC1)O5)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O MBWUSSKCCUMJHO-ZGXDEBHDSA-N 0.000 title abstract 2
- MBWUSSKCCUMJHO-DVDUUUGDSA-N Solamargine Natural products O([C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)[C@H](CO)O[C@@H]1O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]5[C@@H](C)[C@@]6(O[C@H]5C4)NC[C@H](C)CC6)CC3)CC=2)CC1)[C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](C)O1 MBWUSSKCCUMJHO-DVDUUUGDSA-N 0.000 title abstract 2
- BLRFKPWRSOZROE-UHFFFAOYSA-N beta-Solamargin Natural products CC1CCC2(NC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(COC8OC(C)C(OC9OC(C)C(O)C(O)C9O)C(O)C8O)C(O)C(O)C7O BLRFKPWRSOZROE-UHFFFAOYSA-N 0.000 title 1
- BIMWFUACEQGSPS-UHFFFAOYSA-N solamargin Natural products CC1CCC2(NC1)OC3CC4C5CC=C6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(COC8OC(C)C(O)C(O)C8O)C(O)C(O)C7OC9OC(C)C(O)C(O)C9O BIMWFUACEQGSPS-UHFFFAOYSA-N 0.000 title 1
- 235000002634 Solanum Nutrition 0.000 abstract 1
- 241000207763 Solanum Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229930182470 glycoside Natural products 0.000 abstract 1
- 150000002338 glycosides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0057—Nitrogen and oxygen
- C07J71/0068—Nitrogen and oxygen at position 16(17)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01120144 | 2001-08-21 | ||
| PCT/EP2002/009349 WO2003018604A1 (en) | 2001-08-21 | 2002-08-21 | Synthesis of solanum glycosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60227536D1 true DE60227536D1 (de) | 2008-08-21 |
Family
ID=8178388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60227536T Expired - Fee Related DE60227536D1 (de) | 2001-08-21 | 2002-08-21 | Chemische synthese von solamargin |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040259814A1 (enExample) |
| EP (1) | EP1421100B1 (enExample) |
| JP (1) | JP4267448B2 (enExample) |
| AT (1) | ATE400580T1 (enExample) |
| AU (1) | AU2002336998B2 (enExample) |
| BR (1) | BR0212397A (enExample) |
| CA (1) | CA2458183A1 (enExample) |
| DE (1) | DE60227536D1 (enExample) |
| WO (1) | WO2003018604A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60207878T2 (de) * | 2001-09-28 | 2006-08-17 | Glycomed Sciences Ltd., Turramurra | Lösungsmittelextraktionsverfahren |
| EP1618122A1 (en) * | 2003-04-30 | 2006-01-25 | GlycoMed Sciences (UK) Limited, c/o Consolidated Capital Limited | Synthesis of solanum glycosides |
| EP1654271B1 (en) * | 2003-07-08 | 2008-12-10 | GlycoMed Sciences Limited | Steroid modified solatrioses |
| US20090012013A9 (en) * | 2003-07-08 | 2009-01-08 | Lawson Christopher J | Steroid modified solatrioses |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU654474B2 (en) * | 1990-01-18 | 1994-11-10 | Cura Nominees Pty Ltd | Glycoalkaloids |
| US5612317A (en) * | 1994-08-04 | 1997-03-18 | Holick; Michael F. | Method for delivering estrogen |
| DE19621177A1 (de) * | 1996-05-24 | 1997-11-27 | Basf Ag | Kohlenhydratderivate und ihre Synthese an fester Phase |
| AU718293B2 (en) * | 1996-09-13 | 2000-04-13 | Daikin Industries, Ltd. | Lewis X derivatives |
| TW471968B (en) * | 1999-08-25 | 2002-01-11 | Committee On Chinese Medicine | Solamargine pharmaceutical composition for killing cancer cells |
-
2002
- 2002-08-21 EP EP02772183A patent/EP1421100B1/en not_active Expired - Lifetime
- 2002-08-21 WO PCT/EP2002/009349 patent/WO2003018604A1/en not_active Ceased
- 2002-08-21 DE DE60227536T patent/DE60227536D1/de not_active Expired - Fee Related
- 2002-08-21 AT AT02772183T patent/ATE400580T1/de not_active IP Right Cessation
- 2002-08-21 JP JP2003523263A patent/JP4267448B2/ja not_active Expired - Fee Related
- 2002-08-21 CA CA002458183A patent/CA2458183A1/en not_active Abandoned
- 2002-08-21 AU AU2002336998A patent/AU2002336998B2/en not_active Expired - Fee Related
- 2002-08-21 BR BR0212397-5A patent/BR0212397A/pt not_active IP Right Cessation
-
2004
- 2004-02-20 US US10/783,821 patent/US20040259814A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005502671A (ja) | 2005-01-27 |
| JP4267448B2 (ja) | 2009-05-27 |
| EP1421100A1 (en) | 2004-05-26 |
| EP1421100B1 (en) | 2008-07-09 |
| WO2003018604A1 (en) | 2003-03-06 |
| ATE400580T1 (de) | 2008-07-15 |
| US20040259814A1 (en) | 2004-12-23 |
| AU2002336998B2 (en) | 2009-01-29 |
| CA2458183A1 (en) | 2003-03-06 |
| BR0212397A (pt) | 2004-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |