DE60224720D1 - Re - Google Patents

Re

Info

Publication number
DE60224720D1
DE60224720D1 DE60224720T DE60224720T DE60224720D1 DE 60224720 D1 DE60224720 D1 DE 60224720D1 DE 60224720 T DE60224720 T DE 60224720T DE 60224720 T DE60224720 T DE 60224720T DE 60224720 D1 DE60224720 D1 DE 60224720D1
Authority
DE
Germany
Prior art keywords
region
library
repertory
libraries
fragments including
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60224720T
Other languages
English (en)
Inventor
Nobuyoshi Shimizu
Atsushi Takayanagi
Michiyo Okui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Keio University
Original Assignee
Keio University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Keio University filed Critical Keio University
Application granted granted Critical
Publication of DE60224720D1 publication Critical patent/DE60224720D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
DE60224720T 2001-11-22 2002-11-22 Re Expired - Lifetime DE60224720D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001358602 2001-11-22
PCT/JP2002/012236 WO2003044198A1 (fr) 2001-11-22 2002-11-22 Banque d'anticorps artificiels dotee d'un super repertoire

Publications (1)

Publication Number Publication Date
DE60224720D1 true DE60224720D1 (en) 2008-03-06

Family

ID=19169753

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60224720T Expired - Lifetime DE60224720D1 (en) 2001-11-22 2002-11-22 Re

Country Status (7)

Country Link
US (1) US8178320B2 (de)
EP (1) EP1457559B1 (de)
JP (1) JP4171844B2 (de)
AT (1) ATE384129T1 (de)
AU (1) AU2002366039A1 (de)
DE (1) DE60224720D1 (de)
WO (1) WO2003044198A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1670932B1 (de) * 2003-08-27 2011-03-30 Proterec Ltd Bibliotheken rekombinanter chimärischer proteine
JP4524414B2 (ja) * 2004-08-24 2010-08-18 学校法人東海大学 糖結合性ファージ提示型抗体の解析方法
JP2006055141A (ja) * 2004-08-24 2006-03-02 Tokai Univ 糖鎖構造に特異的な抗体の同定方法
JP2007306828A (ja) * 2006-05-17 2007-11-29 Tokai Univ 非還元マンノース残基を認識するファージ提示型単鎖抗体
JP5239766B2 (ja) 2008-11-14 2013-07-17 富士通セミコンダクター株式会社 レイアウト設計方法
JP5965838B2 (ja) 2010-06-04 2016-08-10 東亞合成株式会社 抗体およびその利用
NZ710422A (en) 2013-01-24 2016-11-25 Scripps Korea Antibody Inst Protein combination-based fv library, and preparation method therefor
WO2016114567A1 (ko) * 2015-01-13 2016-07-21 이화여자대학교 산학협력단 신규 항체 라이브러리 제조방법 및 이로부터 제조된 라이브러리
ES2881683T3 (es) * 2015-05-21 2021-11-30 Full Spectrum Genetics Inc Procedimiento para mejorar las características de las proteínas
JP7324744B2 (ja) 2017-08-21 2023-08-10 アダジーン インコーポレイテッド ダイナミックヒト抗体軽鎖ライブラリー
US11578426B2 (en) 2017-08-21 2023-02-14 Adagene Inc. Dynamic human heavy chain antibody libraries
CN112557644B (zh) * 2020-12-21 2024-03-22 珠海碳云智能科技有限公司 用于对目标抗体进行检测的多肽的筛选方法及其筛选的多肽的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2136092T3 (es) * 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5855885A (en) * 1993-01-22 1999-01-05 Smith; Rodger Isolation and production of catalytic antibodies using phage technology
EP0759976A4 (de) 1994-03-30 2001-02-07 Igen Int Inc Die isolierung und herstellung von katalytischen antikörpern mittels phagentechnologie
PT937098E (pt) 1995-06-07 2002-12-31 Invitrogen Corp Clonagem recombinatoria in vitro utilizando locais de recombinacao modificados
EP0996718B1 (de) 1997-03-18 2008-12-24 Novozymes A/S Methode zur herstellung einer bibliothek mittels dna-shuffling
JP4206154B2 (ja) 1997-11-13 2009-01-07 大日本住友製薬株式会社 変異型ｌｏｘＰ配列とその応用
US6662113B1 (en) 1997-12-15 2003-12-09 Fujisawa Pharmaceutical Co., Ltd. Digital correlation of test samples and the screening of interactions between the same
IT1303776B1 (it) * 1998-11-19 2001-02-23 S I S S A Scuola Internaz Supe Processo per la preparazione di genoteche, di polipeptidi utilizzandodette genoteche e i polipepti ottenuti.
JP2003510019A (ja) * 1999-07-14 2003-03-18 クロンテック・ラボラトリーズ・インコーポレーテッド リコンビナーゼを利用した発現ベクターを作製する方法、およびこの方法を実施するために使用する組成物
EP1092768A1 (de) * 1999-10-16 2001-04-18 ARTEMIS Pharmaceuticals GmbH Konstrukt zum bedingten einfangen und Disruption von Genen
GB0008419D0 (en) * 2000-04-05 2000-05-24 Bioinvent Int Ab A method for invitro molecular evolution of antibody function
US6912504B1 (en) * 2000-04-28 2005-06-28 Blackarrow, Inc. Distributing television advertisements over the internet
US20020072097A1 (en) * 2000-07-07 2002-06-13 Delcardayre Stephen Molecular breeding of transposable elements
WO2002040685A2 (en) 2000-11-16 2002-05-23 Cornell Research Foundation, Inc. Vectors for conditional gene inactivation

Also Published As

Publication number Publication date
US20060057632A1 (en) 2006-03-16
EP1457559A1 (de) 2004-09-15
JPWO2003044198A1 (ja) 2005-03-24
WO2003044198A1 (fr) 2003-05-30
AU2002366039A1 (en) 2003-06-10
EP1457559B1 (de) 2008-01-16
ATE384129T1 (de) 2008-02-15
EP1457559A4 (de) 2005-10-12
US8178320B2 (en) 2012-05-15
JP4171844B2 (ja) 2008-10-29

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Legal Events

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