DE60216142D1 - Tropan-derivate mit dopamin-wiederaufnahme-hemmer-wirkung für die behandlung von ischämischen erkrankungen - Google Patents

Tropan-derivate mit dopamin-wiederaufnahme-hemmer-wirkung für die behandlung von ischämischen erkrankungen

Info

Publication number
DE60216142D1
DE60216142D1 DE60216142T DE60216142T DE60216142D1 DE 60216142 D1 DE60216142 D1 DE 60216142D1 DE 60216142 T DE60216142 T DE 60216142T DE 60216142 T DE60216142 T DE 60216142T DE 60216142 D1 DE60216142 D1 DE 60216142D1
Authority
DE
Germany
Prior art keywords
treatment
ischemic
illnesses
inhibitor effect
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60216142T
Other languages
English (en)
Other versions
DE60216142T2 (de
Inventor
Jorgen Scheel-Krueger
Christian B Ronn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Publication of DE60216142D1 publication Critical patent/DE60216142D1/de
Application granted granted Critical
Publication of DE60216142T2 publication Critical patent/DE60216142T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60216142T 2001-11-30 2002-11-28 Tropan-Derivate mit einer die Wiederaufnahme von Dopamin hemmenden Aktivität zur Behandlung von ischämischen Erkrankungen Expired - Lifetime DE60216142T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK200101781 2001-11-30
DKPA200101781 2001-11-30
PCT/DK2002/000796 WO2003045388A1 (en) 2001-11-30 2002-11-28 Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases

Publications (2)

Publication Number Publication Date
DE60216142D1 true DE60216142D1 (de) 2006-12-28
DE60216142T2 DE60216142T2 (de) 2007-09-06

Family

ID=8160868

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60216142T Expired - Lifetime DE60216142T2 (de) 2001-11-30 2002-11-28 Tropan-Derivate mit einer die Wiederaufnahme von Dopamin hemmenden Aktivität zur Behandlung von ischämischen Erkrankungen

Country Status (7)

Country Link
US (1) US7381733B2 (de)
EP (1) EP1453511B1 (de)
JP (1) JP2005511639A (de)
AT (1) ATE345135T1 (de)
AU (1) AU2002365288A1 (de)
DE (1) DE60216142T2 (de)
WO (1) WO2003045388A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005529156A (ja) * 2002-03-28 2005-09-29 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ トロパン化合物
JP2006517567A (ja) 2003-02-12 2006-07-27 ニューロサーチ、アクティーゼルスカブ 新規８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
AR045141A1 (es) * 2003-07-31 2005-10-19 Neurosearch As Sales de tartrato de 2- metoximetil-3-(3,4-diclorofenil)-8-azabiciclo (3,2,1) octano. composiciones farmaceuticas que los contienen y usos de las mismas.
KR20060125805A (ko) * 2003-11-18 2006-12-06 베링거 인겔하임 인터내셔날 게엠베하 고체 약제학적 제제 형태
DE102004004965B4 (de) * 2004-01-31 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung eines 2-(Ethoxymethyl)-tropanderivates
US20080200498A1 (en) * 2005-07-12 2008-08-21 Angelo Ceci Pharmaceutical Composition For The Treatment Of Disorders Of Sexual Desire
GB0703998D0 (en) * 2007-03-01 2007-04-11 Glaxo Group Ltd Novel salt
US8221345B2 (en) 2007-05-30 2012-07-17 Smiths Medical Asd, Inc. Insulin pump based expert system

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179567A (en) * 1978-04-10 1979-12-18 Sterling Drug Inc. 2-Aryltropane compounds
US5272160A (en) * 1989-05-17 1993-12-21 Pfizer Inc 2-piperidino-1-alkanol derivatives as antiischemic agents
US6329520B1 (en) * 1990-08-09 2001-12-11 Research Triangle Institute Cocaine receptor binding ligands
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
AU672644B2 (en) 1992-12-23 1996-10-10 Neurosearch A/S Aryl substituted heterocyclic compounds
DK154192D0 (da) * 1992-12-23 1992-12-23 Neurosearch As Heterocycliske forbindelser
AU671163B2 (en) 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds
AU672052B2 (en) 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds
DK0756596T3 (da) 1994-04-19 2002-12-23 Neurosearch As Tropan-2-aldoximderivater som neurotransmitter-genoptagelsesinhibitorer
US6046213A (en) 1994-08-18 2000-04-04 Pfizer Inc. Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
HUP9802534A3 (en) 1995-11-02 1999-06-28 Neurosearch As Fused tropane-derivatives as neurotransmitter reuptake inhibitors
PT885220E (pt) 1996-02-22 2001-11-30 Neurosearch As Derivados de tropano a sua preparacao e utilizacao
AU7847800A (en) * 1999-10-15 2001-04-30 Mayo Foundation For Medical Education And Research Topical anesthetics useful for treating cancer, autoimmune diseases and ischemia
US20040077634A1 (en) * 2001-02-15 2004-04-22 Ulrik Lademann Treatment of diseases characterized by excessive or insufficient cell death

Also Published As

Publication number Publication date
DE60216142T2 (de) 2007-09-06
US7381733B2 (en) 2008-06-03
JP2005511639A (ja) 2005-04-28
EP1453511B1 (de) 2006-11-15
US20050020621A1 (en) 2005-01-27
EP1453511A1 (de) 2004-09-08
ATE345135T1 (de) 2006-12-15
WO2003045388A1 (en) 2003-06-05
AU2002365288A1 (en) 2003-06-10

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: RONN, LARS, BALLERUP, DK

Inventor name: SCHEEL-KRUEGER, JORGEN, BALLERUP, DK

8364 No opposition during term of opposition