DE602007012833D1 - Mit lanthionin verwandte verbindungen zur behandlung entzündlicher krankheiten - Google Patents
Mit lanthionin verwandte verbindungen zur behandlung entzündlicher krankheitenInfo
- Publication number
- DE602007012833D1 DE602007012833D1 DE602007012833T DE602007012833T DE602007012833D1 DE 602007012833 D1 DE602007012833 D1 DE 602007012833D1 DE 602007012833 T DE602007012833 T DE 602007012833T DE 602007012833 T DE602007012833 T DE 602007012833T DE 602007012833 D1 DE602007012833 D1 DE 602007012833D1
- Authority
- DE
- Germany
- Prior art keywords
- lanthionine
- compounds
- derivatives
- treatment
- provides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 208000027866 inflammatory disease Diseases 0.000 title 1
- XIVVIYYWXOMYOD-UHFFFAOYSA-N lanthionine ketimine Chemical class OC(=O)C1CSCC(C(O)=O)=N1 XIVVIYYWXOMYOD-UHFFFAOYSA-N 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- GDTAKZOTFKBAGC-UHFFFAOYSA-N thiomorpholine-3,4-dicarboxylic acid Chemical class OC(=O)C1CSCCN1C(O)=O GDTAKZOTFKBAGC-UHFFFAOYSA-N 0.000 abstract 2
- DWPCPZJAHOETAG-IMJSIDKUSA-N L-lanthionine Chemical compound OC(=O)[C@@H](N)CSC[C@H](N)C(O)=O DWPCPZJAHOETAG-IMJSIDKUSA-N 0.000 abstract 1
- 230000003215 anti-neuroinflammatory effect Effects 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- 230000008499 blood brain barrier function Effects 0.000 abstract 1
- 210000001218 blood-brain barrier Anatomy 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- DWPCPZJAHOETAG-UHFFFAOYSA-N meso-lanthionine Natural products OC(=O)C(N)CSCC(N)C(O)=O DWPCPZJAHOETAG-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75725206P | 2006-01-09 | 2006-01-09 | |
| US78179406P | 2006-03-13 | 2006-03-13 | |
| US80414906P | 2006-06-07 | 2006-06-07 | |
| PCT/US2007/060277 WO2007082208A2 (en) | 2006-01-09 | 2007-01-09 | Lanthionine-related compounds for the treatment of inflammatory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602007012833D1 true DE602007012833D1 (de) | 2011-04-14 |
Family
ID=38051848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602007012833T Active DE602007012833D1 (de) | 2006-01-09 | 2007-01-09 | Mit lanthionin verwandte verbindungen zur behandlung entzündlicher krankheiten |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7683055B2 (enExample) |
| EP (1) | EP1981862B1 (enExample) |
| JP (1) | JP5367377B2 (enExample) |
| AT (1) | ATE500236T1 (enExample) |
| AU (1) | AU2007204757B2 (enExample) |
| CA (1) | CA2636042C (enExample) |
| DE (1) | DE602007012833D1 (enExample) |
| DK (1) | DK1981862T3 (enExample) |
| PT (1) | PT1981862E (enExample) |
| WO (1) | WO2007082208A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2305834A1 (en) * | 2009-10-02 | 2011-04-06 | Advanced Practical Diagnostics N.V. | Haplotype of KATIII gene |
| EP2524925B1 (en) * | 2009-12-28 | 2016-08-17 | Ajinomoto Co., Inc. | Lanthionine derivative |
| WO2011140215A2 (en) * | 2010-05-04 | 2011-11-10 | Virginia Tech Intellectual Properties, Inc. | Lanthionine synthetase component c-like proteins as molecular targets for preventing and treating diseases and disorders |
| WO2012027455A1 (en) * | 2010-08-24 | 2012-03-01 | The University Of Toledo | Glutathione-lanthionine compounds and methods related thereto |
| CN102670796A (zh) * | 2012-05-22 | 2012-09-19 | 广西天天乐药业股份有限公司 | 一种治疗脾胃虚弱的中药及其制备方法 |
| JP2017141497A (ja) * | 2016-02-12 | 2017-08-17 | 二村 芳弘 | エラスチン増加作用を呈するメチルランチオニン誘導体の製造方法 |
| US11084836B2 (en) * | 2016-02-26 | 2021-08-10 | The University Of Toledo | Compositions useful in therapy of autophagy-related pathologies, and methods of making and using the same |
| US10882831B2 (en) * | 2017-02-23 | 2021-01-05 | The University Of Toledo | Compositions useful in therapy of autophagy-related pathologies, and methods of making and using the same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2283186A (en) * | 1942-05-19 | Thiazane-j | ||
| US6025395A (en) * | 1994-04-15 | 2000-02-15 | Duke University | Method of preventing or delaying the onset and progression of Alzheimer's disease and related disorders |
| MXPA03006321A (es) * | 2001-01-16 | 2003-10-06 | Genset Sa | Tratamiento de trastornos del sistema nervioso central usando antagonistas de d-aminoacido oxidasa y d-aspartato oxidasa. |
| US20030166554A1 (en) * | 2001-01-16 | 2003-09-04 | Genset, S.A. | Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists |
| US20030185754A1 (en) * | 2001-01-16 | 2003-10-02 | Genset, S.A. | Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists |
-
2007
- 2007-01-09 DE DE602007012833T patent/DE602007012833D1/de active Active
- 2007-01-09 US US11/621,469 patent/US7683055B2/en not_active Expired - Fee Related
- 2007-01-09 AT AT07710015T patent/ATE500236T1/de active
- 2007-01-09 WO PCT/US2007/060277 patent/WO2007082208A2/en not_active Ceased
- 2007-01-09 EP EP07710015A patent/EP1981862B1/en not_active Not-in-force
- 2007-01-09 DK DK07710015.4T patent/DK1981862T3/da active
- 2007-01-09 PT PT07710015T patent/PT1981862E/pt unknown
- 2007-01-09 AU AU2007204757A patent/AU2007204757B2/en not_active Ceased
- 2007-01-09 JP JP2008549685A patent/JP5367377B2/ja not_active Expired - Fee Related
- 2007-01-09 CA CA2636042A patent/CA2636042C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1981862B1 (en) | 2011-03-02 |
| US7683055B2 (en) | 2010-03-23 |
| DK1981862T3 (da) | 2011-06-14 |
| JP2009522377A (ja) | 2009-06-11 |
| EP1981862A2 (en) | 2008-10-22 |
| ATE500236T1 (de) | 2011-03-15 |
| JP5367377B2 (ja) | 2013-12-11 |
| AU2007204757B2 (en) | 2012-09-06 |
| US20070197515A1 (en) | 2007-08-23 |
| WO2007082208A3 (en) | 2007-09-13 |
| CA2636042C (en) | 2014-10-14 |
| WO2007082208A2 (en) | 2007-07-19 |
| AU2007204757A1 (en) | 2007-07-19 |
| PT1981862E (pt) | 2011-06-01 |
| CA2636042A1 (en) | 2007-07-19 |
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