DE602007011745D1 - Mikrofluidische Vorrichtung, Mischverfahren und Verwendung der Vorrichtung - Google Patents

Mikrofluidische Vorrichtung, Mischverfahren und Verwendung der Vorrichtung

Info

Publication number
DE602007011745D1
DE602007011745D1 DE602007011745T DE602007011745T DE602007011745D1 DE 602007011745 D1 DE602007011745 D1 DE 602007011745D1 DE 602007011745 T DE602007011745 T DE 602007011745T DE 602007011745 T DE602007011745 T DE 602007011745T DE 602007011745 D1 DE602007011745 D1 DE 602007011745D1
Authority
DE
Germany
Prior art keywords
chamber
liquid
hydrophilic
chambers
correspondence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007011745T
Other languages
German (de)
English (en)
Inventor
Mario Curcio
Micheal Glauser
Carlo Effenhauser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Publication of DE602007011745D1 publication Critical patent/DE602007011745D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3035—Micromixers using surface tension to mix, move or hold the fluids
    • B01F33/30351—Micromixers using surface tension to mix, move or hold the fluids using hydrophilic/hydrophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3017—Mixing chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00837—Materials of construction comprising coatings other than catalytically active coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/0086—Dimensions of the flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0694—Valves, specific forms thereof vents used to stop and induce flow, backpressure valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/088—Passive control of flow resistance by specific surface properties

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
DE602007011745T 2007-07-10 2007-07-10 Mikrofluidische Vorrichtung, Mischverfahren und Verwendung der Vorrichtung Active DE602007011745D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07013434A EP2016997B1 (en) 2007-07-10 2007-07-10 Microfluidic device, method of mixing and use of the device

Publications (1)

Publication Number Publication Date
DE602007011745D1 true DE602007011745D1 (de) 2011-02-17

Family

ID=38752765

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007011745T Active DE602007011745D1 (de) 2007-07-10 2007-07-10 Mikrofluidische Vorrichtung, Mischverfahren und Verwendung der Vorrichtung

Country Status (5)

Country Link
US (1) US8911683B2 (https=)
EP (1) EP2016997B1 (https=)
JP (1) JP5027070B2 (https=)
AT (1) ATE494061T1 (https=)
DE (1) DE602007011745D1 (https=)

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US20070047388A1 (en) * 2005-08-25 2007-03-01 Rockwell Scientific Licensing, Llc Fluidic mixing structure, method for fabricating same, and mixing method
WO2008027558A2 (en) 2006-08-31 2008-03-06 Codon Devices, Inc. Iterative nucleic acid assembly using activation of vector-encoded traits
EP2213364A1 (en) * 2009-01-30 2010-08-04 Albert-Ludwigs-Universität Freiburg Phase guide patterns for liquid manipulation
US10207240B2 (en) 2009-11-03 2019-02-19 Gen9, Inc. Methods and microfluidic devices for the manipulation of droplets in high fidelity polynucleotide assembly
WO2011066185A1 (en) 2009-11-25 2011-06-03 Gen9, Inc. Microfluidic devices and methods for gene synthesis
WO2011085075A2 (en) 2010-01-07 2011-07-14 Gen9, Inc. Assembly of high fidelity polynucleotides
US8204172B1 (en) 2010-03-17 2012-06-19 General Electric Company System and method of prior image constrained image reconstruction using short scan image data and objective function minimization
WO2012024696A2 (en) * 2010-08-20 2012-02-23 Purdue Research Foundation Laser treatment of a medium for microfluidics and various other applications
CN103502448B (zh) 2010-11-12 2017-03-29 Gen9股份有限公司 核酸合成的方法和设备
EP2637780B1 (en) 2010-11-12 2022-02-09 Gen9, Inc. Protein arrays and methods of using and making the same
ES2640954T3 (es) * 2011-06-09 2017-11-07 Pp Energy Aps Dispositivo de elevación para conectar dos segmentos de pala de rotor de una turbina eólica
LT2944693T (lt) 2011-08-26 2019-08-26 Gen9, Inc. Kompozicijos ir būdai, skirti nukleorūgščių didelio tikslumo sąrankai
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
CN111876409A (zh) 2012-04-24 2020-11-03 Gen9股份有限公司 在体外克隆中分选核酸和多重制备物的方法
AU2013280661A1 (en) 2012-06-25 2015-01-22 Gen9, Inc. Methods for nucleic acid assembly and high throughput sequencing
JP6056865B2 (ja) * 2012-09-19 2017-01-11 日本電気株式会社 分析チップ、及び分析装置
FR2996544B1 (fr) * 2012-10-08 2015-03-13 Ecole Polytech Circuit microfluidique permettant la mise en contact de gouttes de plusieurs fluides, et procede microfluidique correspondant.
US10037382B2 (en) * 2012-10-29 2018-07-31 Kyocera Corporation Surface acoustic wave sensor
JP5839526B1 (ja) * 2015-02-06 2016-01-06 秋田県 微小液滴を形成する反応デバイス及びこれを用いた電界撹拌方法
US9604209B2 (en) 2015-03-19 2017-03-28 International Business Machines Corporation Microfluidic device with anti-wetting, venting areas
KR102614682B1 (ko) 2017-12-11 2023-12-19 덴카 주식회사 액체 시료 검사 키트용 막 담체, 액체 시료 검사 키트, 액체 시료 검사 키트의 제조 방법, 액체 시료의 검사 방법 및 막 담체
GB201801019D0 (en) * 2018-01-22 2018-03-07 Q Linea Ab Sample holder
EP3953044A4 (en) * 2019-04-08 2022-06-01 Technion Research & Development Foundation Limited MULTIPLEXED NETWORK OF NANOLITER DROPLET NETWORK DEVICES
JP7316286B2 (ja) * 2019-07-08 2023-07-27 積水化学工業株式会社 送液方法
JP7561041B2 (ja) * 2020-04-28 2024-10-03 デクセリアルズ株式会社 検査チップ、及びその製造方法
CN113804658B (zh) * 2020-06-11 2023-06-06 京东方科技集团股份有限公司 微流控流道结构、检测系统及其使用方法
JP2023544985A (ja) 2020-09-23 2023-10-26 エフ． ホフマン－ラ ロシュ アーゲー 電極上の金属ナノ粒子の支援により分析物を検出するための方法
KR102919524B1 (ko) * 2021-11-26 2026-02-02 한국기계연구원 개폐형 디지털 유전자 증폭 키트 어셈블리
WO2024137351A1 (en) 2022-12-19 2024-06-27 Anchorline Biolabs, Inc. Capillary partitioning microfluidics
CN116687084B (zh) * 2023-04-13 2025-08-05 青岛大学 一种湿度可控的口罩及口罩湿度的控制方法

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WO1998040735A1 (en) * 1997-03-12 1998-09-17 Kyoto Daiichi Kagaku Co., Ltd. Testing instrument for analyzing liquid sample
US5904824A (en) 1997-03-07 1999-05-18 Beckman Instruments, Inc. Microfluidic electrophoresis device
DE10002500A1 (de) 2000-01-21 2001-07-26 Univ Albert Ludwigs Freiburg Kapillarkraftmischer
AU2002255517A1 (en) * 2001-02-09 2002-10-08 The University Of Illinois Method and structure for microfluidic flow guiding
EP1643231A1 (en) * 2003-07-09 2006-04-05 Olympus Corporation Device and method for carrying and treating liquid
US20070047388A1 (en) * 2005-08-25 2007-03-01 Rockwell Scientific Licensing, Llc Fluidic mixing structure, method for fabricating same, and mixing method
DE502006007372D1 (de) * 2006-05-22 2010-08-19 Micronas Gmbh Vorrichtung zum Mischen von Mikrotröpfchen

Also Published As

Publication number Publication date
US20090016932A1 (en) 2009-01-15
EP2016997B1 (en) 2011-01-05
ATE494061T1 (de) 2011-01-15
US8911683B2 (en) 2014-12-16
EP2016997A1 (en) 2009-01-21
JP2009025301A (ja) 2009-02-05
JP5027070B2 (ja) 2012-09-19

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