DE602007010321D1 - Multinetzwerk-nervenzellenassay-plattform mit parallelaufzeichnungsmöglichkeit - Google Patents

Multinetzwerk-nervenzellenassay-plattform mit parallelaufzeichnungsmöglichkeit

Info

Publication number
DE602007010321D1
DE602007010321D1 DE602007010321T DE602007010321T DE602007010321D1 DE 602007010321 D1 DE602007010321 D1 DE 602007010321D1 DE 602007010321 T DE602007010321 T DE 602007010321T DE 602007010321 T DE602007010321 T DE 602007010321T DE 602007010321 D1 DE602007010321 D1 DE 602007010321D1
Authority
DE
Germany
Prior art keywords
wells
recording
amplifiers
amplifying
nerve cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007010321T
Other languages
English (en)
Inventor
Guenter W Gross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Texas
Original Assignee
University of North Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Texas filed Critical University of North Texas
Publication of DE602007010321D1 publication Critical patent/DE602007010321D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5032—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on intercellular interactions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/023—Sending and receiving of information, e.g. using bluetooth
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2857—Seizure disorders; Epilepsy

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Clinical Laboratory Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE602007010321T 2006-09-18 2007-09-12 Multinetzwerk-nervenzellenassay-plattform mit parallelaufzeichnungsmöglichkeit Active DE602007010321D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84539906P 2006-09-18 2006-09-18
PCT/US2007/019780 WO2008100287A2 (en) 2006-09-18 2007-09-12 Multinetwork nerve cell assay platform with parallel recording capability

Publications (1)

Publication Number Publication Date
DE602007010321D1 true DE602007010321D1 (de) 2010-12-16

Family

ID=39690646

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007010321T Active DE602007010321D1 (de) 2006-09-18 2007-09-12 Multinetzwerk-nervenzellenassay-plattform mit parallelaufzeichnungsmöglichkeit

Country Status (7)

Country Link
US (1) US8460921B2 (de)
EP (1) EP2064546B1 (de)
JP (1) JP5232785B2 (de)
AT (1) ATE487135T1 (de)
DE (1) DE602007010321D1 (de)
ES (1) ES2355528T3 (de)
WO (1) WO2008100287A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9279801B2 (en) 2013-07-26 2016-03-08 Axion Biosystems, Inc. Devices, systems and methods for high-throughput electrophysiology
DE102014003432B3 (de) * 2014-03-11 2015-05-07 NeuroProof GmbH Verfahren zum Testen neuroaktiver Substanzen
WO2016025646A1 (en) 2014-08-12 2016-02-18 Axion Biosystems, Inc. Cell-based biosensor array and associated methods for manufacturing the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08149998A (ja) * 1994-11-28 1996-06-11 Nippon Telegr & Teleph Corp <Ntt> 細胞に対する薬剤等の効果を判定する装置及び方法
EP1171628A2 (de) * 1999-04-15 2002-01-16 Devgen NV Verfahren zum screening von verbindungen
US20030154501A1 (en) * 1999-04-15 2003-08-14 Devgen, N.V. Compound screening method
US6686193B2 (en) * 2000-07-10 2004-02-03 Vertex Pharmaceuticals, Inc. High throughput method and system for screening candidate compounds for activity against target ion channels
US7615356B2 (en) * 2000-07-10 2009-11-10 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
EP1406086A4 (de) * 2001-06-05 2007-10-31 Matsushita Electric Ind Co Ltd Signaldetektionssensor mit mehrfachelektrode
US8048289B2 (en) * 2004-09-10 2011-11-01 Molecular Devices, Llc Parallel patch clamp system
US8560041B2 (en) * 2004-10-04 2013-10-15 Braingate Co., Llc Biological interface system
US20070017530A1 (en) * 2005-06-10 2007-01-25 Syed Naweed I Detecting electrical activity and assessing agents for the ability to influence electrical activity

Also Published As

Publication number Publication date
ATE487135T1 (de) 2010-11-15
WO2008100287A2 (en) 2008-08-21
EP2064546B1 (de) 2010-11-03
JP5232785B2 (ja) 2013-07-10
US8460921B2 (en) 2013-06-11
JP2010518885A (ja) 2010-06-03
EP2064546A2 (de) 2009-06-03
ES2355528T3 (es) 2011-03-28
WO2008100287A3 (en) 2008-12-18
US20090291466A1 (en) 2009-11-26

Similar Documents

Publication Publication Date Title
Kerr et al. Imaging input and output of neocortical networks in vivo
ATE543095T1 (de) Sensor-array
JP2012508611A5 (de)
WO2005070495A3 (en) Neural stimulation array providing proximity of electrodes to cells via cellular migration
WO2004053071A3 (en) Method for discovering neurogenic agents
WO2006055338A3 (en) Methods and systems for identifying and isolating stem cells and for observing mitochondrial structure and distribution in living cells
SG157263A1 (en) Bioreactor system for multi-stage biological wastewater treatment
Lu et al. Input-specific maturation of synaptic dynamics of parvalbumin interneurons in primary visual cortex
Rocha et al. Extracellular electrical recording of pH-triggered bursts in C6 glioma cell populations
WO2007010441A3 (en) Apparatus and method for coupling implanted electrodes to nervous tissue
WO2008149976A1 (ja) 心臓リエントリーモデルチップおよび心臓リエントリーモデルチップによる薬剤の評価装置および方法
DE602007010321D1 (de) Multinetzwerk-nervenzellenassay-plattform mit parallelaufzeichnungsmöglichkeit
WO2004103394A3 (en) Method and compositions for nerve regeneration
WO2009039639A8 (en) Nucleotide triphosphate with an electroactive label conjugated to the gamma phosphate
WO2006113889A3 (en) Compositions and methods for modulating interleukin-10
WO2010027785A3 (en) Measurement of biological targets
SE0302746D0 (sv) Multielectrode
ATE540313T1 (de) Identifizierung von keimbahnfähigen embryonischen stammzellen
WO2006130990A3 (en) Detecting electrical activity and assessing agents for the ability to influence electrical activity in neuronal cell networks
Lewis et al. Neuroprotection supports signal processing in the hippocampus of Syrian hamsters, a facultative hibernator
Rokib et al. Effects of some selected socio-demographic variables on male migrants in Bangladesh
ATE526402T1 (de) Hilfssonden und verfahren zur verwendung davon
Zorzi et al. Automatic extraction of axonal arbor morphology applied to h-iPSC-derived neurons
GB0803004D0 (en) Genetic variation associated with coeliac disease
Ziesel et al. Validation of Electrical Signaling in In Vitro Cell Cultures on Multielectrode Arrays through Simultaneous Calcium Imaging