DE602007004743D1 - Verfahren zum nachweis von wechselwirkungen auf einem mikroarray mittels kernmagnetresonanz - Google Patents

Verfahren zum nachweis von wechselwirkungen auf einem mikroarray mittels kernmagnetresonanz

Info

Publication number
DE602007004743D1
DE602007004743D1 DE602007004743T DE602007004743T DE602007004743D1 DE 602007004743 D1 DE602007004743 D1 DE 602007004743D1 DE 602007004743 T DE602007004743 T DE 602007004743T DE 602007004743 T DE602007004743 T DE 602007004743T DE 602007004743 D1 DE602007004743 D1 DE 602007004743D1
Authority
DE
Germany
Prior art keywords
microarray
probes
magnetic resonance
nuclear magnetic
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007004743T
Other languages
English (en)
Inventor
Glen Mchale
Michael Ian Newton
Martin Bencsik
Gareth Wynn Cave
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nottingham Trent University
Original Assignee
Nottingham Trent University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nottingham Trent University filed Critical Nottingham Trent University
Publication of DE602007004743D1 publication Critical patent/DE602007004743D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
    • G01R33/3808—Magnet assemblies for single-sided MR wherein the magnet assembly is located on one side of a subject only; Magnet assemblies for inside-out MR, e.g. for MR in a borehole or in a blood vessel, or magnet assemblies for fringe-field MR
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/281—Means for the use of in vitro contrast agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
    • G01R33/3806—Open magnet assemblies for improved access to the sample, e.g. C-type or U-type magnets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
    • G01R33/56341—Diffusion imaging
DE602007004743T 2006-09-20 2007-09-19 Verfahren zum nachweis von wechselwirkungen auf einem mikroarray mittels kernmagnetresonanz Active DE602007004743D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0618514.4A GB0618514D0 (en) 2006-09-20 2006-09-20 Method of detecting interactions on a microarray using nuclear magnetic resonance
PCT/GB2007/003562 WO2008035073A2 (en) 2006-09-20 2007-09-19 Method of detecting interactions on a microarray using nuclear magnetic resonance

Publications (1)

Publication Number Publication Date
DE602007004743D1 true DE602007004743D1 (de) 2010-03-25

Family

ID=37421304

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007004743T Active DE602007004743D1 (de) 2006-09-20 2007-09-19 Verfahren zum nachweis von wechselwirkungen auf einem mikroarray mittels kernmagnetresonanz

Country Status (6)

Country Link
US (1) US20100160173A1 (de)
EP (1) EP2069769B1 (de)
AT (1) ATE457453T1 (de)
DE (1) DE602007004743D1 (de)
GB (1) GB0618514D0 (de)
WO (1) WO2008035073A2 (de)

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US20140103927A1 (en) 2011-02-01 2014-04-17 Uri Rapoport Low-field magnetic resonance system (lf-mrs) for producing an mri image
US10359378B2 (en) 2012-05-14 2019-07-23 Board Of Trustees Of Michigan State University Nuclear magnetic resonance apparatus, systems, and methods
US9696393B2 (en) * 2013-01-28 2017-07-04 The Regents Of The University Of California MRI receiver coil providing an enhanced signal-to-noise ratio
US9747789B2 (en) 2013-03-31 2017-08-29 Case Western Reserve University Magnetic resonance imaging with switched-mode current-source amplifier having gallium nitride field effect transistors for parallel transmission in MRI
US10076264B2 (en) 2013-03-31 2018-09-18 Case Western Reserve University System and method for quantitative magnetic resonance (MR) analysis using T1 mapping
CN106324008B (zh) * 2015-07-02 2018-10-16 中国石油天然气股份有限公司 核磁共振测井波谱的校正方法
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WO2022229107A1 (en) * 2021-04-26 2022-11-03 Fundació Institut De Bioenginyeria De Catalunya System and method for nmr analysis of a physiological condition in an analyte
US11835610B2 (en) * 2021-07-16 2023-12-05 The General Hospital Corporation Systems and methods for susceptibility contrast imaging of nanoparticles at low magnetic fields
CN115932555B (zh) * 2023-02-23 2023-05-26 长春光华微电子设备工程中心有限公司 一种探针位置的获得方法以及探针台

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Also Published As

Publication number Publication date
ATE457453T1 (de) 2010-02-15
EP2069769B1 (de) 2010-02-10
EP2069769A2 (de) 2009-06-17
WO2008035073A3 (en) 2008-08-28
GB0618514D0 (en) 2006-11-01
US20100160173A1 (en) 2010-06-24
WO2008035073A2 (en) 2008-03-27

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