DE602005023334D1 - Isotopenmarkierte chinolinderivate als liganden des adenosin-a3-rezeptors - Google Patents
Isotopenmarkierte chinolinderivate als liganden des adenosin-a3-rezeptorsInfo
- Publication number
- DE602005023334D1 DE602005023334D1 DE602005023334T DE602005023334T DE602005023334D1 DE 602005023334 D1 DE602005023334 D1 DE 602005023334D1 DE 602005023334 T DE602005023334 T DE 602005023334T DE 602005023334 T DE602005023334 T DE 602005023334T DE 602005023334 D1 DE602005023334 D1 DE 602005023334D1
- Authority
- DE
- Germany
- Prior art keywords
- receptor
- isotopenmarked
- adenosine
- ligands
- chinoline derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003446 ligand Substances 0.000 title abstract 2
- 102000008161 Adenosine A3 Receptor Human genes 0.000 title 1
- 108010060261 Adenosine A3 Receptor Proteins 0.000 title 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
- C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0402371A HUP0402371A2 (en) | 2004-11-15 | 2004-11-15 | Novel 125-i-labeled amino-quinoline derivatives |
| PCT/HU2005/000120 WO2006051341A1 (en) | 2004-11-15 | 2005-11-09 | Isotopically marked quinoline derivatives as adenosin a3 receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005023334D1 true DE602005023334D1 (de) | 2010-10-14 |
Family
ID=89985606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005023334T Active DE602005023334D1 (de) | 2004-11-15 | 2005-11-09 | Isotopenmarkierte chinolinderivate als liganden des adenosin-a3-rezeptors |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7964731B2 (de) |
| EP (1) | EP1814857B1 (de) |
| JP (1) | JP2008519816A (de) |
| KR (1) | KR20070084202A (de) |
| CN (1) | CN101056859B (de) |
| AT (1) | ATE479660T1 (de) |
| AU (1) | AU2005303544B2 (de) |
| BR (1) | BRPI0517816A (de) |
| CA (1) | CA2588073A1 (de) |
| DE (1) | DE602005023334D1 (de) |
| HU (1) | HUP0402371A2 (de) |
| IL (1) | IL182971A0 (de) |
| MX (1) | MX2007005768A (de) |
| RU (1) | RU2379290C2 (de) |
| WO (1) | WO2006051341A1 (de) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6921825B2 (en) * | 1998-09-16 | 2005-07-26 | King Pharmaceuticuals Research & Development, Inc. | Adenosine A3 receptor modulators |
| RU2278112C2 (ru) * | 2001-05-31 | 2006-06-20 | Санофи-Авентис | Производные аминохинолина и аминопиридина и их применение в качестве лигандов аденозина a3 |
-
2004
- 2004-11-15 HU HU0402371A patent/HUP0402371A2/hu unknown
-
2005
- 2005-11-09 JP JP2007540727A patent/JP2008519816A/ja not_active Withdrawn
- 2005-11-09 MX MX2007005768A patent/MX2007005768A/es active IP Right Grant
- 2005-11-09 DE DE602005023334T patent/DE602005023334D1/de active Active
- 2005-11-09 RU RU2007122396/04A patent/RU2379290C2/ru not_active IP Right Cessation
- 2005-11-09 BR BRPI0517816-9A patent/BRPI0517816A/pt not_active IP Right Cessation
- 2005-11-09 WO PCT/HU2005/000120 patent/WO2006051341A1/en active Application Filing
- 2005-11-09 AT AT05806497T patent/ATE479660T1/de not_active IP Right Cessation
- 2005-11-09 AU AU2005303544A patent/AU2005303544B2/en not_active Ceased
- 2005-11-09 CN CN2005800388317A patent/CN101056859B/zh not_active Expired - Fee Related
- 2005-11-09 EP EP05806497A patent/EP1814857B1/de not_active Not-in-force
- 2005-11-09 KR KR1020077010909A patent/KR20070084202A/ko not_active Application Discontinuation
- 2005-11-09 CA CA002588073A patent/CA2588073A1/en not_active Abandoned
-
2007
- 2007-05-03 IL IL182971A patent/IL182971A0/en unknown
- 2007-05-14 US US11/748,098 patent/US7964731B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006051341A1 (en) | 2006-05-18 |
| CN101056859A (zh) | 2007-10-17 |
| HUP0402371A2 (en) | 2006-09-28 |
| RU2379290C2 (ru) | 2010-01-20 |
| RU2007122396A (ru) | 2008-12-20 |
| JP2008519816A (ja) | 2008-06-12 |
| CN101056859B (zh) | 2010-05-05 |
| MX2007005768A (es) | 2007-07-16 |
| US7964731B2 (en) | 2011-06-21 |
| EP1814857B1 (de) | 2010-09-01 |
| EP1814857A1 (de) | 2007-08-08 |
| BRPI0517816A (pt) | 2008-10-21 |
| AU2005303544B2 (en) | 2011-06-02 |
| CA2588073A1 (en) | 2006-05-18 |
| ATE479660T1 (de) | 2010-09-15 |
| HU0402371D0 (en) | 2005-03-29 |
| IL182971A0 (en) | 2007-08-19 |
| AU2005303544A1 (en) | 2006-05-18 |
| KR20070084202A (ko) | 2007-08-24 |
| US20080027225A1 (en) | 2008-01-31 |
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