DE602004027165D1 - Reduzierung von arthritis und lahmheit bei personen unter supllement von wachstumshormon freisetzendem hormon (ghrh) - Google Patents
Reduzierung von arthritis und lahmheit bei personen unter supllement von wachstumshormon freisetzendem hormon (ghrh)Info
- Publication number
- DE602004027165D1 DE602004027165D1 DE602004027165T DE602004027165T DE602004027165D1 DE 602004027165 D1 DE602004027165 D1 DE 602004027165D1 DE 602004027165 T DE602004027165 T DE 602004027165T DE 602004027165 T DE602004027165 T DE 602004027165T DE 602004027165 D1 DE602004027165 D1 DE 602004027165D1
- Authority
- DE
- Germany
- Prior art keywords
- ghrh
- arthritis
- liberty
- reduction
- growth hormone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010003246 arthritis Diseases 0.000 title abstract 2
- 102000018997 Growth Hormone Human genes 0.000 title 1
- 108010051696 Growth Hormone Proteins 0.000 title 1
- 239000000122 growth hormone Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102100022831 Somatoliberin Human genes 0.000 abstract 1
- 101710142969 Somatoliberin Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 208000030175 lameness Diseases 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53375603P | 2003-12-31 | 2003-12-31 | |
PCT/US2004/042497 WO2005065722A2 (en) | 2003-12-31 | 2004-12-17 | Reducing arthritis and lameness in subjects by growth hormone releasing hormone (ghrh) supplementation |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004027165D1 true DE602004027165D1 (de) | 2010-06-24 |
Family
ID=34748953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004027165T Active DE602004027165D1 (de) | 2003-12-31 | 2004-12-17 | Reduzierung von arthritis und lahmheit bei personen unter supllement von wachstumshormon freisetzendem hormon (ghrh) |
Country Status (6)
Country | Link |
---|---|
US (1) | US8188056B2 (de) |
EP (1) | EP1711187B1 (de) |
AT (1) | ATE467417T1 (de) |
CA (1) | CA2592891C (de) |
DE (1) | DE602004027165D1 (de) |
WO (1) | WO2005065722A2 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1713828B1 (de) * | 2004-01-20 | 2011-04-27 | VGX Pharmaceuticals, LLC | Erhöhte sekretion/retention von wachstumshormonfreisetzendem hormon (ghrh) aus muskelzellen durch speziesspezifisches signalpeptid |
US7846720B2 (en) * | 2005-01-26 | 2010-12-07 | Vgx Pharmaceuticals, Inc. | Optimized high yield synthetic plasmids |
KR20140068000A (ko) | 2011-06-15 | 2014-06-05 | 크론테크 파마 아베 | 주사 바늘 및 장치 |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4226857A (en) * | 1979-03-30 | 1980-10-07 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4223020A (en) * | 1979-03-30 | 1980-09-16 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4223019A (en) * | 1979-03-30 | 1980-09-16 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4228156A (en) * | 1979-03-30 | 1980-10-14 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4228158A (en) | 1979-03-30 | 1980-10-14 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4224316A (en) * | 1979-03-30 | 1980-09-23 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4223021A (en) * | 1979-03-30 | 1980-09-16 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
JPS5841973A (ja) * | 1981-09-07 | 1983-03-11 | 東邦レーヨン株式会社 | 炭素繊維用エマルジヨン型サイジング剤 |
US4410512A (en) | 1981-12-28 | 1983-10-18 | Beckman Instruments, Inc. | Combinations having synergistic pituitary growth hormone releasing activity |
US5134120A (en) | 1984-08-03 | 1992-07-28 | Cornell Research Foundation, Inc. | Use of growth hormone to enhance porcine weight gain |
US5036045A (en) | 1985-09-12 | 1991-07-30 | The University Of Virginia Alumni Patents Foundation | Method for increasing growth hormone secretion |
US4833166A (en) * | 1987-05-01 | 1989-05-23 | Grosvenor Clark E | Growth hormone releasing hormone complementary peptides |
US4839344A (en) * | 1987-06-12 | 1989-06-13 | Eastman Kodak Company | Polypeptide compounds having growth hormone releasing activity |
USRE33699E (en) * | 1987-07-09 | 1991-09-24 | International Minerals & Chemical Corp. | Growth hormone-releasing factor analogs |
FR2622455B1 (fr) * | 1987-11-04 | 1991-07-12 | Agronomique Inst Nat Rech | Application du facteur de stimulation de la secretion de l'hormone de croissance humaine, de ses fragments actifs et des analogues correspondants, pour augmenter la production laitiere et le poids des nouveau-nes chez les mammiferes |
US5023322A (en) * | 1988-08-31 | 1991-06-11 | Mta Kutatas-Es Szervezetelemzo Intezete | Analogs of growth hormone releasing factor (GRF) and a method for the preparation thereof |
US5084442A (en) * | 1988-09-06 | 1992-01-28 | Hoffmann-La Roche Inc. | Cyclic growth hormone releasing factor analogs and method for the manufacture thereof |
US5134210A (en) | 1989-07-27 | 1992-07-28 | Edwards Bill R | Acrylic resin composition |
US5137872A (en) * | 1989-09-18 | 1992-08-11 | Pitman-Moore, Inc. | Growth hormone-releasing factor analogs |
IL98638A (en) * | 1990-06-29 | 1995-07-31 | Hoffmann La Roche | Analogs of the factor that releases human growth hormone, their preparation and pharmaceutical preparations that contain them |
US5486505A (en) | 1990-07-24 | 1996-01-23 | Polygen Holding Corporation | Polypeptide compounds having growth hormone releasing activity |
AU662731B2 (en) * | 1991-04-09 | 1995-09-14 | F. Hoffmann-La Roche Ag | Growth hormone releasing factor analogs |
US5663146A (en) * | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
US5298422A (en) | 1991-11-06 | 1994-03-29 | Baylor College Of Medicine | Myogenic vector systems |
US5545130A (en) | 1992-04-08 | 1996-08-13 | Genetronics, Inc. | Flow through electroporation method |
US6132419A (en) | 1992-05-22 | 2000-10-17 | Genetronics, Inc. | Electroporetic gene and drug therapy |
US5507724A (en) | 1992-07-01 | 1996-04-16 | Genetronics, Inc. | Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells |
DE4228457A1 (de) | 1992-08-27 | 1994-04-28 | Beiersdorf Ag | Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen |
US5702359A (en) * | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
US5439440A (en) * | 1993-04-01 | 1995-08-08 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
FR2722208B1 (fr) | 1994-07-05 | 1996-10-04 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique |
US5792747A (en) | 1995-01-24 | 1998-08-11 | The Administrators Of The Tulane Educational Fund | Highly potent agonists of growth hormone releasing hormone |
WO1996032126A1 (en) | 1995-04-14 | 1996-10-17 | The Administrators Of The Tulane Educational Fund | Analogs of growth hormone-releasing factor |
WO1997007826A1 (en) | 1995-08-29 | 1997-03-06 | Cbr Laboratories, Inc. | In vivo electroporation of cells |
EP0988388A2 (de) * | 1997-07-24 | 2000-03-29 | Valentis Inc. | Ghrh-expressionssystem und dessen verwendungsmethoden |
CN1635898A (zh) * | 1999-07-26 | 2005-07-06 | 贝勒医学院 | 超级活性的猪生长激素释放激素类似物 |
-
2004
- 2004-12-17 WO PCT/US2004/042497 patent/WO2005065722A2/en active Application Filing
- 2004-12-17 EP EP04814650A patent/EP1711187B1/de active Active
- 2004-12-17 AT AT04814650T patent/ATE467417T1/de not_active IP Right Cessation
- 2004-12-17 US US11/015,935 patent/US8188056B2/en active Active
- 2004-12-17 CA CA2592891A patent/CA2592891C/en active Active
- 2004-12-17 DE DE602004027165T patent/DE602004027165D1/de active Active
Also Published As
Publication number | Publication date |
---|---|
US8188056B2 (en) | 2012-05-29 |
WO2005065722A3 (en) | 2005-09-09 |
WO2005065722A2 (en) | 2005-07-21 |
US20050182014A1 (en) | 2005-08-18 |
EP1711187A2 (de) | 2006-10-18 |
CA2592891A1 (en) | 2005-07-21 |
CA2592891C (en) | 2013-05-28 |
EP1711187B1 (de) | 2010-05-12 |
ATE467417T1 (de) | 2010-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Choe et al. | Oxytocin mediates entrainment of sensory stimuli to social cues of opposing valence | |
Carter | Oxytocin pathways and the evolution of human behavior | |
Chambers et al. | Functional localization in the cerebellum: Somatotopic organization in cortex and nuclei | |
Azzopardi et al. | The role of cholinergic midbrain neurons in startle and prepulse inhibition | |
Vianna et al. | Fos-like immunoreactive neurons following electrical stimulation of the dorsal periaqueductal gray at freezing and escape thresholds | |
ES2661500T3 (es) | Variantes de HMGB1 y sus usos | |
DE60228741D1 (de) | T1r-geschmacksrezeptoren und dafür kodierende gene | |
ATE286118T1 (de) | Anwendungen für humane nicht autologe, mesenchymale stammzellen | |
IL154794A0 (en) | Remedies for heart failure | |
Poindron et al. | Sensory and physiological determinants of maternal behavior in the goat (Capra hircus) | |
Yin et al. | A central amygdala–ventrolateral periaqueductal gray matter pathway for pain in a mouse model of depression-like behavior | |
DE602005027322D1 (de) | Verwendung von antikörpern gegen tweak zur behandlung von schlaganfall | |
Xie et al. | A brain-to-spinal sensorimotor loop for repetitive self-grooming | |
Chambers et al. | Functional localization in the cerebellum | |
WO2004067719A3 (en) | Growth hormone releasing hormone (ghrh) for use in reducing culling in herd animals | |
DE602004027165D1 (de) | Reduzierung von arthritis und lahmheit bei personen unter supllement von wachstumshormon freisetzendem hormon (ghrh) | |
CY1110418T1 (el) | Αναστολη της αλληλεπιδρασης μεταξυ οξειδωμενων πρωτεϊνων και cd36 ή ο μηχανισμος δρασης τους | |
Dwyer | Management of blind horses | |
Yoshida et al. | Estrogen reduces the excitability of the female rat medial amygdala afferents from the medial preoptic area but not those from the lateral septum | |
BRPI0508053A (pt) | método de combater toxicidade causada por um composto antifolato, e de tratar uma doença, usos de enzima que possui atividade de carbóxi-peptidase g, de composto antifolato, de agente de resgate de rota de folato, e de enzima que possui atividade de carbóxi-peptidase g e de um agente de resgate de rota de folato, sistema terapêutico, e, método ex vivo de clivar um grupo l-glutamato terminal de um composto, de determinar a taxa e/ou extenção de clivagem de um composto, e de clivagem de um composto | |
DE60208447D1 (de) | Sprachverbindungssystem zwischen menschen und tieren | |
ATE491782T1 (de) | Verfahren zum selektiven expandieren, auswählen und anreichern von stamm- bzw. vorläuferzellen- populationen | |
van der Zee et al. | Whole body vibration, cognition, and the brain | |
Bennett et al. | Is vasoactive intestinal peptide an inhibitory transmitter in the circular but not the longitudinal muscle of guinea‐pig colon? | |
DE60336596D1 (de) | Ortspezifische verabreichung von aktiven substanzen im darm |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |