DE602004019127D1 - Verfahren zur herstellung von citalopram - Google Patents

Verfahren zur herstellung von citalopram

Info

Publication number
DE602004019127D1
DE602004019127D1 DE602004019127T DE602004019127T DE602004019127D1 DE 602004019127 D1 DE602004019127 D1 DE 602004019127D1 DE 602004019127 T DE602004019127 T DE 602004019127T DE 602004019127 T DE602004019127 T DE 602004019127T DE 602004019127 D1 DE602004019127 D1 DE 602004019127D1
Authority
DE
Germany
Prior art keywords
citalopram
preparation
cyanophthalide
cyclized
bromine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602004019127T
Other languages
English (en)
Inventor
Giovanni Cotticelli
Lernia Gianluca Di
Silvia Milanesi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adorkem Technology SpA
Original Assignee
Adorkem Technology SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adorkem Technology SpA filed Critical Adorkem Technology SpA
Publication of DE602004019127D1 publication Critical patent/DE602004019127D1/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic System
    • C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic System without C-Metal linkages
DE602004019127T 2003-10-28 2004-10-22 Verfahren zur herstellung von citalopram Expired - Fee Related DE602004019127D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03425693A EP1506963B1 (de) 2003-10-28 2003-10-28 Verfahren zur Herstellung von Citalopram
PCT/EP2004/052626 WO2005049595A1 (en) 2003-10-28 2004-10-22 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
DE602004019127D1 true DE602004019127D1 (de) 2009-03-05

Family

ID=33560918

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60300502T Expired - Fee Related DE60300502T2 (de) 2003-10-28 2003-10-28 Verfahren zur Herstellung von Citalopram
DE602004019127T Expired - Fee Related DE602004019127D1 (de) 2003-10-28 2004-10-22 Verfahren zur herstellung von citalopram

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60300502T Expired - Fee Related DE60300502T2 (de) 2003-10-28 2003-10-28 Verfahren zur Herstellung von Citalopram

Country Status (15)

Country Link
US (1) US20070060759A1 (de)
EP (2) EP1506963B1 (de)
JP (1) JP2007511477A (de)
CN (1) CN1875013A (de)
AT (2) ATE293106T1 (de)
BR (1) BRPI0415778A (de)
CA (1) CA2543155A1 (de)
DE (2) DE60300502T2 (de)
DK (2) DK1506963T3 (de)
ES (1) ES2240931T3 (de)
HK (1) HK1075041A1 (de)
PL (1) PL379659A1 (de)
PT (1) PT1506963E (de)
SI (1) SI1506963T1 (de)
WO (1) WO2005049595A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9314444B2 (en) 2009-01-12 2016-04-19 Biokier, Inc. Composition and method for treatment of NASH
US9006288B2 (en) 2009-01-12 2015-04-14 Biokier, Inc. Composition and method for treatment of diabetes
WO2010081079A2 (en) 2009-01-12 2010-07-15 Biokier Inc. Composition and method for treatment of diabetes
JP2013505936A (ja) 2009-09-23 2013-02-21 バイオキアー・インコーポレイテッド 糖尿病の治療のための組成物および方法
CN108451941A (zh) 2011-05-02 2018-08-28 拜奥基尔公司 治疗糖尿病的组合物和方法
US20150073057A1 (en) 2013-09-06 2015-03-12 Biokier, Inc. Composition and method for treatment of diabetes
CN111302971B (zh) * 2018-12-12 2023-08-22 上海奥博生物医药股份有限公司 一种连续制备5-氰二醇的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
WO1998019513A2 (en) * 1997-07-08 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
HUP0002953A3 (en) * 1997-11-11 2002-12-28 Lundbeck & Co As H Method for preparation of citalopram and intermediates used for them
WO2002060886A1 (en) * 2001-01-30 2002-08-08 Orion Corporation, Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate

Also Published As

Publication number Publication date
HK1075041A1 (en) 2005-12-02
DK1506963T3 (da) 2005-08-01
EP1682526A1 (de) 2006-07-26
EP1506963B1 (de) 2005-04-13
JP2007511477A (ja) 2007-05-10
DE60300502T2 (de) 2006-02-23
BRPI0415778A (pt) 2006-12-26
ATE420870T1 (de) 2009-01-15
DE60300502D1 (de) 2005-05-19
EP1682526B1 (de) 2009-01-14
EP1506963A1 (de) 2005-02-16
PT1506963E (pt) 2005-08-31
ES2240931T3 (es) 2005-10-16
US20070060759A1 (en) 2007-03-15
SI1506963T1 (en) 2005-10-31
PL379659A1 (pl) 2006-10-30
DK1682526T3 (da) 2009-03-23
CN1875013A (zh) 2006-12-06
CA2543155A1 (en) 2005-06-02
ATE293106T1 (de) 2005-04-15
WO2005049595A1 (en) 2005-06-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee