DE602004010251D1 - Reduzierung von mikroarray schwankungen durch interne referenzpositionen - Google Patents

Reduzierung von mikroarray schwankungen durch interne referenzpositionen

Info

Publication number
DE602004010251D1
DE602004010251D1 DE602004010251T DE602004010251T DE602004010251D1 DE 602004010251 D1 DE602004010251 D1 DE 602004010251D1 DE 602004010251 T DE602004010251 T DE 602004010251T DE 602004010251 T DE602004010251 T DE 602004010251T DE 602004010251 D1 DE602004010251 D1 DE 602004010251D1
Authority
DE
Germany
Prior art keywords
microarray
variations
reduction
internal reference
reference positions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602004010251T
Other languages
English (en)
Other versions
DE602004010251T2 (de
Inventor
Parameswara Meda Reddy
Kurt Brillhart
Firdous Farooqui
Daniel A Keys
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Coulter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Publication of DE602004010251D1 publication Critical patent/DE602004010251D1/de
Application granted granted Critical
Publication of DE602004010251T2 publication Critical patent/DE602004010251T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE602004010251T 2003-05-16 2004-05-14 Reduktion von mikroarray-schwankungen durch interne referenzpunkte Expired - Fee Related DE602004010251T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US439811 2003-05-16
US10/439,811 US20040229226A1 (en) 2003-05-16 2003-05-16 Reducing microarray variation with internal reference spots
PCT/US2004/015209 WO2004104230A1 (en) 2003-05-16 2004-05-14 Reducing microarray variation with internal reference spots

Publications (2)

Publication Number Publication Date
DE602004010251D1 true DE602004010251D1 (de) 2008-01-03
DE602004010251T2 DE602004010251T2 (de) 2008-09-25

Family

ID=33417896

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004010251T Expired - Fee Related DE602004010251T2 (de) 2003-05-16 2004-05-14 Reduktion von mikroarray-schwankungen durch interne referenzpunkte

Country Status (6)

Country Link
US (1) US20040229226A1 (de)
EP (1) EP1625233B1 (de)
JP (1) JP2007500851A (de)
CN (1) CN1771333A (de)
DE (1) DE602004010251T2 (de)
WO (1) WO2004104230A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005118855A1 (en) * 2004-05-20 2005-12-15 Beckman Coulter, Inc. Assay system using labeled oligonucleotides
DE102005062003A1 (de) * 2005-12-22 2007-06-28 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Vorrichtung und Verfahren zur Detektion und/oder quantitativen Messung eines Zielmediums
WO2008104922A1 (en) * 2007-03-01 2008-09-04 Koninklijke Philips Electronics N.V. Grid pattern determination system
EP2140266A1 (de) * 2007-03-26 2010-01-06 Toxispot A/S Quantifizierung von analytmolekülen unter verwendung mehrerer referenzmoleküle und korrelationsfunktionen
WO2012068372A1 (en) * 2010-11-17 2012-05-24 Aushon Biosystems Method of and system for printing in-well calibration features
EP3650117B1 (de) 2011-11-14 2022-07-20 Aushon Biosystems, Inc. Systeme und verfahren zur verbesserung der konsistenz der testleistung

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807755A (en) * 1987-08-06 1998-09-15 Multilyte Limited Determination of ambient concentrations of several analytes
GB9404709D0 (en) * 1994-03-11 1994-04-27 Multilyte Ltd Binding assay
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US6037124A (en) * 1996-09-27 2000-03-14 Beckman Coulter, Inc. Carboxylated polyvinylidene fluoride solid supports for the immobilization of biomolecules and methods of use thereof
US5888740A (en) * 1997-09-19 1999-03-30 Genaco Biomedical Products, Inc. Detection of aneuploidy and gene deletion by PCR-based gene- dose co-amplification of chromosome specific sequences with synthetic sequences with synthetic internal controls
US6351712B1 (en) * 1998-12-28 2002-02-26 Rosetta Inpharmatics, Inc. Statistical combining of cell expression profiles
US6251601B1 (en) * 1999-02-02 2001-06-26 Vysis, Inc. Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays
US6268141B1 (en) * 1999-05-12 2001-07-31 Beckman Coulter, Inc. Immobilization of unmodified biopolymers to acyl fluoride activated substrates
JP3469504B2 (ja) * 1999-06-01 2003-11-25 日立ソフトウエアエンジニアリング株式会社 マイクロアレイチップ及びそのインデックス方法
US6362004B1 (en) * 1999-11-09 2002-03-26 Packard Biochip Technologies, Llc Apparatus and method for using fiducial marks on a microarray substrate
JP3502803B2 (ja) * 2000-03-06 2004-03-02 日立ソフトウエアエンジニアリング株式会社 マイクロアレイ、マイクロアレイ作製方法及びマイクロアレイにおけるピン間スポット量誤差補正方法
AU2001286929A1 (en) * 2000-09-01 2002-03-13 Board Of Regents, The University Of Texas System Compositions and methods for the generation of single stranded cdna microarrays with accurate universal quantitation reference
JP3537752B2 (ja) * 2000-09-01 2004-06-14 日立ソフトウエアエンジニアリング株式会社 バイオチップを用いたハイブリダイゼーション反応の実験結果表示方法及び実験誤差評価方法
EP1203945B1 (de) * 2000-10-26 2006-12-20 Agilent Technologies, Inc. (a Delaware corporation) Mikroarray
CA2446531A1 (en) * 2001-05-07 2002-11-14 Amersham Biosciences Corp Design of artificial genes for use as controls in gene expression analysis systems
EP1423534A4 (de) * 2001-08-16 2006-08-30 Stratagene California Kontrollnukleinsäuren enthaltende zusammensetzungen und verfahren
WO2003025580A1 (en) * 2001-09-19 2003-03-27 Ingenium Pharmaceuticals Ag Parallel miniaturized quantitative immunoassays
AU2002361146A1 (en) * 2001-12-21 2003-07-09 Pamgene B.V. Normalisation of microarray data based on hybridisation with an internal reference
US20030198967A1 (en) * 2002-04-23 2003-10-23 Matson Robert S. Multi-functional microarrays and methods
US7422911B2 (en) * 2002-10-31 2008-09-09 Agilent Technologies, Inc. Composite flexible array substrate having flexible support

Also Published As

Publication number Publication date
WO2004104230A1 (en) 2004-12-02
US20040229226A1 (en) 2004-11-18
DE602004010251T2 (de) 2008-09-25
CN1771333A (zh) 2006-05-10
JP2007500851A (ja) 2007-01-18
EP1625233A1 (de) 2006-02-15
EP1625233B1 (de) 2007-11-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee