DE602004007662D1 - Rapamycin-carbohydrate derivate - Google Patents
Rapamycin-carbohydrate derivateInfo
- Publication number
- DE602004007662D1 DE602004007662D1 DE602004007662T DE602004007662T DE602004007662D1 DE 602004007662 D1 DE602004007662 D1 DE 602004007662D1 DE 602004007662 T DE602004007662 T DE 602004007662T DE 602004007662 T DE602004007662 T DE 602004007662T DE 602004007662 D1 DE602004007662 D1 DE 602004007662D1
- Authority
- DE
- Germany
- Prior art keywords
- rapamycin
- derivatives
- carbohydrate derivatives
- profiles
- pharmacokinetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47136703P | 2003-05-16 | 2003-05-16 | |
US471367P | 2003-05-16 | ||
US54624004P | 2004-02-20 | 2004-02-20 | |
US546240P | 2004-02-20 | ||
US56284004P | 2004-04-16 | 2004-04-16 | |
US562840P | 2004-04-16 | ||
PCT/CA2004/000724 WO2004101583A1 (en) | 2003-05-16 | 2004-05-14 | Rapamycin carbohydrate derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE602004007662D1 true DE602004007662D1 (de) | 2007-08-30 |
DE602004007662T2 DE602004007662T2 (de) | 2007-11-22 |
Family
ID=33458770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004007662T Expired - Fee Related DE602004007662T2 (de) | 2003-05-16 | 2004-05-14 | Rapamycin-carbohydrate derivate |
Country Status (19)
Country | Link |
---|---|
US (3) | US7160867B2 (de) |
EP (2) | EP1785430A1 (de) |
JP (1) | JP2007503452A (de) |
KR (1) | KR20060031603A (de) |
AT (1) | ATE367396T1 (de) |
AU (1) | AU2004238408A1 (de) |
BR (1) | BRPI0411171A (de) |
CA (1) | CA2525907A1 (de) |
DE (1) | DE602004007662T2 (de) |
DK (1) | DK1644392T3 (de) |
ES (1) | ES2286637T3 (de) |
HR (1) | HRP20070383T3 (de) |
MX (1) | MXPA05012376A (de) |
NO (1) | NO20055283L (de) |
NZ (1) | NZ543479A (de) |
PL (1) | PL1644392T3 (de) |
PT (1) | PT1644392E (de) |
TW (1) | TW200511991A (de) |
WO (1) | WO2004101583A1 (de) |
Families Citing this family (38)
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US6955661B1 (en) | 1999-01-25 | 2005-10-18 | Atrium Medical Corporation | Expandable fluoropolymer device for delivery of therapeutic agents and method of making |
US7160867B2 (en) * | 2003-05-16 | 2007-01-09 | Isotechnika, Inc. | Rapamycin carbohydrate derivatives |
US8021331B2 (en) * | 2003-09-15 | 2011-09-20 | Atrium Medical Corporation | Method of coating a folded medical device |
US7585517B2 (en) * | 2003-09-18 | 2009-09-08 | Macusight, Inc. | Transscleral delivery |
US7563780B1 (en) * | 2004-06-18 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Heparin prodrugs and drug delivery stents formed therefrom |
US9000040B2 (en) | 2004-09-28 | 2015-04-07 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
SI1848431T1 (sl) * | 2005-02-09 | 2016-05-31 | Santen Pharmaceutical Co., Ltd. | Tekoče formulacije za zdravljenje bolezni ali stanj |
US8663639B2 (en) * | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
GB0504994D0 (en) | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Novel compounds |
EP1879632A2 (de) * | 2005-04-29 | 2008-01-23 | Atrium Medical Corporation | Arzneistoffzuführungsbeschichtung zur verwendung bei einer medizinischen vorrichtung sowie verfahren zur behandlung von gefässverletzung |
AU2006314444C1 (en) | 2005-11-21 | 2018-01-04 | Novartis Ag | Neuroendocrine tumor treatment using mTOR inhibitors |
JP5528708B2 (ja) | 2006-02-09 | 2014-06-25 | 参天製薬株式会社 | 安定な製剤ならびにそれらを調製および使用する方法 |
US8222271B2 (en) * | 2006-03-23 | 2012-07-17 | Santen Pharmaceutical Co., Ltd. | Formulations and methods for vascular permeability-related diseases or conditions |
GB0609963D0 (en) * | 2006-05-19 | 2006-06-28 | Biotica Tech Ltd | Novel compounds |
US20080265343A1 (en) * | 2007-04-26 | 2008-10-30 | International Business Machines Corporation | Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof |
US20090253733A1 (en) * | 2008-04-02 | 2009-10-08 | Biointeractions, Ltd. | Rapamycin carbonate esters |
CN101676291B (zh) * | 2008-09-18 | 2012-05-09 | 上海海和药物研究开发有限公司 | 一类雷帕霉素碳酸酯类似物、其药物组合物及其制备方法和用途 |
US20120064143A1 (en) | 2008-11-11 | 2012-03-15 | The Board Of Regents Of The University Of Texas System | Inhibition of mammalian target of rapamycin |
US8653043B2 (en) | 2009-01-07 | 2014-02-18 | Wisconsin Alumni Research Foundation | Enhanced neoglycosides through neoglycosylation and methods of use thereof |
US10485792B2 (en) | 2009-08-26 | 2019-11-26 | Hadasit Medical Research Services & Development Limited | Sustained release delivery systems for the prevention and treatment of head and neck cancers |
WO2015103447A1 (en) | 2013-12-31 | 2015-07-09 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
EP2694520A1 (de) * | 2011-04-01 | 2014-02-12 | Sandoz AG | Regioselektive acylierung von rapamycin an der c-42-position |
EP2589383A1 (de) | 2011-11-06 | 2013-05-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin | FKBP-subtypspezifisches Rapamycin-Analogon zur Verwendung bei der Behandlung von Erkrankungen |
MY172706A (en) | 2012-03-23 | 2019-12-11 | Univ Queensland | Immunomodulatory agent and uses therefor |
DK2859001T3 (da) * | 2012-06-08 | 2016-05-30 | Biotronik Ag | Rapamycin 40-o-cyklisk kulbrinteestere, sammensætninger og fremgangsmåder |
US10751450B2 (en) | 2012-06-08 | 2020-08-25 | Biotronik Ag | Rapamycin 40-O-cyclic hydrocarbon esters, compositions and methods |
DK2968281T3 (da) | 2013-03-13 | 2020-11-02 | Univ Texas | Mtor-hæmmere til forebyggelse af vækst af tarmpolyp |
WO2014184734A1 (en) | 2013-05-14 | 2014-11-20 | Novartis Ag | Markers associated with mtor inhibition |
WO2015013581A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
WO2015044854A1 (en) | 2013-09-24 | 2015-04-02 | Novartis Ag | Markers associated with mtor inhibition |
US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
JP6770008B2 (ja) | 2016-05-10 | 2020-10-14 | 浙江海正薬業股▲ふん▼有限公司Zhejiang Hisun Pharmaceutical CO.,LTD. | 水溶性ラパマイシン誘導体 |
WO2018213352A1 (en) | 2017-05-15 | 2018-11-22 | C.R. Bard, Inc. | Medical device with drug-eluting coating and intermediate layer |
WO2019212990A1 (en) | 2018-05-01 | 2019-11-07 | Revolution Medicines, Inc. | C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors |
CN112368289B (zh) | 2018-05-01 | 2024-02-20 | 锐新医药公司 | 作为mtor抑制剂的c26-连接的雷帕霉素类似物 |
EP3880266A1 (de) | 2018-11-14 | 2021-09-22 | Lutonix, Inc. | Medizinische vorrichtung mit wirkstofffreisetzender beschichtung auf modifizierter vorrichtungsoberfläche |
CN113939324A (zh) | 2019-04-08 | 2022-01-14 | 巴德外周血管股份有限公司 | 在经改性装置表面上具有药物洗脱涂层的医疗装置 |
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ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
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DE4236237A1 (de) | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
US5262423A (en) | 1992-10-29 | 1993-11-16 | American Home Products Corporation | Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents |
US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
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-
2004
- 2004-05-13 US US10/845,747 patent/US7160867B2/en not_active Expired - Fee Related
- 2004-05-14 MX MXPA05012376A patent/MXPA05012376A/es active IP Right Grant
- 2004-05-14 ES ES04732898T patent/ES2286637T3/es active Active
- 2004-05-14 CA CA002525907A patent/CA2525907A1/en not_active Abandoned
- 2004-05-14 PT PT04732898T patent/PT1644392E/pt unknown
- 2004-05-14 NZ NZ543479A patent/NZ543479A/en unknown
- 2004-05-14 JP JP2006529489A patent/JP2007503452A/ja not_active Withdrawn
- 2004-05-14 DE DE602004007662T patent/DE602004007662T2/de not_active Expired - Fee Related
- 2004-05-14 PL PL04732898T patent/PL1644392T3/pl unknown
- 2004-05-14 KR KR1020057021769A patent/KR20060031603A/ko not_active Application Discontinuation
- 2004-05-14 DK DK04732898T patent/DK1644392T3/da active
- 2004-05-14 AT AT04732898T patent/ATE367396T1/de not_active IP Right Cessation
- 2004-05-14 EP EP07003243A patent/EP1785430A1/de not_active Withdrawn
- 2004-05-14 AU AU2004238408A patent/AU2004238408A1/en not_active Abandoned
- 2004-05-14 EP EP04732898A patent/EP1644392B1/de active Active
- 2004-05-14 BR BRPI0411171-0A patent/BRPI0411171A/pt not_active IP Right Cessation
- 2004-05-14 WO PCT/CA2004/000724 patent/WO2004101583A1/en active IP Right Grant
- 2004-05-14 TW TW093113648A patent/TW200511991A/zh unknown
-
2005
- 2005-09-15 US US11/229,007 patent/US20060079466A1/en not_active Abandoned
- 2005-11-10 NO NO20055283A patent/NO20055283L/no not_active Application Discontinuation
-
2006
- 2006-11-09 US US11/595,397 patent/US20070099848A1/en not_active Abandoned
-
2007
- 2007-09-05 HR HR20070383T patent/HRP20070383T3/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU2004238408A1 (en) | 2004-11-25 |
NO20055283L (no) | 2005-12-16 |
JP2007503452A (ja) | 2007-02-22 |
US7160867B2 (en) | 2007-01-09 |
US20070099848A1 (en) | 2007-05-03 |
EP1644392B1 (de) | 2007-07-18 |
KR20060031603A (ko) | 2006-04-12 |
US20040235762A1 (en) | 2004-11-25 |
US20060079466A1 (en) | 2006-04-13 |
MXPA05012376A (es) | 2006-05-25 |
PL1644392T3 (pl) | 2007-12-31 |
EP1785430A1 (de) | 2007-05-16 |
DK1644392T3 (da) | 2007-11-12 |
WO2004101583A1 (en) | 2004-11-25 |
ATE367396T1 (de) | 2007-08-15 |
CA2525907A1 (en) | 2004-11-25 |
NO20055283D0 (no) | 2005-11-10 |
BRPI0411171A (pt) | 2006-07-18 |
HRP20070383T3 (en) | 2007-10-31 |
TW200511991A (en) | 2005-04-01 |
NZ543479A (en) | 2008-03-28 |
EP1644392A1 (de) | 2006-04-12 |
ES2286637T3 (es) | 2007-12-01 |
DE602004007662T2 (de) | 2007-11-22 |
PT1644392E (pt) | 2007-08-03 |
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