DE602004001590D1 - Verbessertes Verfahren zur Herstellung von diamidischen Derivaten vom Tripeptid KPV - Google Patents
Verbessertes Verfahren zur Herstellung von diamidischen Derivaten vom Tripeptid KPVInfo
- Publication number
- DE602004001590D1 DE602004001590D1 DE602004001590T DE602004001590T DE602004001590D1 DE 602004001590 D1 DE602004001590 D1 DE 602004001590D1 DE 602004001590 T DE602004001590 T DE 602004001590T DE 602004001590 T DE602004001590 T DE 602004001590T DE 602004001590 D1 DE602004001590 D1 DE 602004001590D1
- Authority
- DE
- Germany
- Prior art keywords
- optionally
- formula
- alkyl
- proline
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 N,N'-diprotected lysine compound Chemical class 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 125000006239 protecting group Chemical group 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 230000008878 coupling Effects 0.000 abstract 3
- 238000010168 coupling process Methods 0.000 abstract 3
- 238000005859 coupling reaction Methods 0.000 abstract 3
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 3
- 239000011707 mineral Substances 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000001470 diamides Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 229910052710 silicon Inorganic materials 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 239000004474 valine Substances 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0300808A FR2850383B1 (fr) | 2003-01-24 | 2003-01-24 | Procede de synthese ameliore de derives diamides du tripeptide kpv |
| FR0300808 | 2003-01-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004001590D1 true DE602004001590D1 (de) | 2006-09-07 |
| DE602004001590T2 DE602004001590T2 (de) | 2007-07-19 |
Family
ID=32525006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004001590T Expired - Lifetime DE602004001590T2 (de) | 2003-01-24 | 2004-01-22 | Verbessertes Verfahren zur Synthese von Diamidderivaten des Tripeptids KPV |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1440977B1 (de) |
| JP (1) | JP4050238B2 (de) |
| AT (1) | ATE334142T1 (de) |
| CY (1) | CY1105713T1 (de) |
| DE (1) | DE602004001590T2 (de) |
| DK (1) | DK1440977T3 (de) |
| ES (1) | ES2270318T3 (de) |
| FR (1) | FR2850383B1 (de) |
| PT (1) | PT1440977E (de) |
| SI (1) | SI1440977T1 (de) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU604751B2 (en) * | 1986-08-08 | 1991-01-03 | Board Of Regents, The University Of Texas System | Anti-inflammatory peptides |
| AU2001297591A1 (en) * | 2000-11-01 | 2002-09-19 | Zengen, Inc. | A sunburn treatment and sunburn prevention method |
-
2003
- 2003-01-24 FR FR0300808A patent/FR2850383B1/fr not_active Expired - Fee Related
-
2004
- 2004-01-22 AT AT04300039T patent/ATE334142T1/de not_active IP Right Cessation
- 2004-01-22 DK DK04300039T patent/DK1440977T3/da active
- 2004-01-22 SI SI200430088T patent/SI1440977T1/sl unknown
- 2004-01-22 PT PT04300039T patent/PT1440977E/pt unknown
- 2004-01-22 DE DE602004001590T patent/DE602004001590T2/de not_active Expired - Lifetime
- 2004-01-22 ES ES04300039T patent/ES2270318T3/es not_active Expired - Lifetime
- 2004-01-22 EP EP04300039A patent/EP1440977B1/de not_active Expired - Lifetime
- 2004-01-26 JP JP2004017359A patent/JP4050238B2/ja not_active Expired - Fee Related
-
2006
- 2006-10-19 CY CY20061101497T patent/CY1105713T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1440977T3 (da) | 2006-11-20 |
| EP1440977A1 (de) | 2004-07-28 |
| ES2270318T3 (es) | 2007-04-01 |
| DE602004001590T2 (de) | 2007-07-19 |
| SI1440977T1 (sl) | 2006-12-31 |
| FR2850383A1 (fr) | 2004-07-30 |
| ATE334142T1 (de) | 2006-08-15 |
| EP1440977B1 (de) | 2006-07-26 |
| JP4050238B2 (ja) | 2008-02-20 |
| JP2004231653A (ja) | 2004-08-19 |
| FR2850383B1 (fr) | 2005-04-15 |
| PT1440977E (pt) | 2006-12-29 |
| CY1105713T1 (el) | 2010-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |