DE60133010D1 - Radioliganden- und bindungs-assay - Google Patents
Radioliganden- und bindungs-assayInfo
- Publication number
- DE60133010D1 DE60133010D1 DE60133010T DE60133010T DE60133010D1 DE 60133010 D1 DE60133010 D1 DE 60133010D1 DE 60133010 T DE60133010 T DE 60133010T DE 60133010 T DE60133010 T DE 60133010T DE 60133010 D1 DE60133010 D1 DE 60133010D1
- Authority
- DE
- Germany
- Prior art keywords
- radioligand
- binding assay
- hydoxyspiro
- naphthalenyl
- methanesulfonamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002287 radioligand Substances 0.000 title abstract 2
- 238000000159 protein binding assay Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21839700P | 2000-07-14 | 2000-07-14 | |
US218397P | 2000-07-14 | ||
PCT/US2001/021731 WO2002005860A1 (en) | 2000-07-14 | 2001-07-10 | Radioligand and binding assay |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60133010D1 true DE60133010D1 (de) | 2008-04-10 |
DE60133010T2 DE60133010T2 (de) | 2009-03-19 |
Family
ID=22814940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60133010T Expired - Lifetime DE60133010T2 (de) | 2000-07-14 | 2001-07-10 | Radioliganden- und bindungs-assay |
Country Status (9)
Country | Link |
---|---|
US (1) | US6838291B2 (de) |
EP (1) | EP1311300B1 (de) |
JP (1) | JP2004512268A (de) |
AT (1) | ATE387222T1 (de) |
AU (1) | AU2001277863A1 (de) |
CA (1) | CA2415295C (de) |
DE (1) | DE60133010T2 (de) |
ES (1) | ES2300345T3 (de) |
WO (1) | WO2002005860A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0121440D0 (en) * | 2001-09-04 | 2001-10-24 | Pfizer Ltd | Assay |
MXPA04002058A (es) * | 2001-09-04 | 2004-06-07 | Pfizer | Prueba. |
US6743797B2 (en) * | 2002-02-22 | 2004-06-01 | Chantest, Inc. | Methods for treating cardiac arrhythmia |
SE0302775D0 (sv) * | 2003-10-20 | 2003-10-20 | Astrazeneca Ab | Chemical compound and assay |
US7927820B2 (en) | 2004-07-20 | 2011-04-19 | Janssen Pharmaceutica Nv | Assay systems and methods for detecting molecules that interact with membrane channels |
US7326772B2 (en) * | 2005-05-12 | 2008-02-05 | Penta Biotech, Inc. | Peptide for assaying hERG channel binding |
JP2011517317A (ja) * | 2008-02-28 | 2011-06-02 | ライフ テクノロジーズ コーポレーション | 蛍光偏光hERGアッセイ法 |
CA2714617A1 (en) | 2008-03-06 | 2009-09-11 | Banyu Pharmaceutical Co., Ltd. | Alkylaminopyridine derivative |
US10412788B2 (en) | 2008-06-13 | 2019-09-10 | Lg Chem, Ltd. | Heating element and manufacturing method thereof |
WO2009155283A2 (en) * | 2008-06-17 | 2009-12-23 | Duke University | Radiolabled cyclopamine assay for the smoothened receptor |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5206240A (en) * | 1989-12-08 | 1993-04-27 | Merck & Co., Inc. | Nitrogen-containing spirocycles |
US5382587A (en) * | 1993-06-30 | 1995-01-17 | Merck & Co., Inc. | Spirocycles |
WO1995023146A1 (en) * | 1994-02-25 | 1995-08-31 | Merck & Co., Inc. | Morphological forms of (+)-n-[1'-(6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl)-3,4-dihydro-4-hydroxyspiro[2h-1-benzopyran-2,4'-piperidin]yl]methanesulfonamide hydrochloride |
WO1997022367A1 (en) * | 1995-12-20 | 1997-06-26 | Merck & Co., Inc. | Radiolabeled growth hormone secretagogue |
-
2001
- 2001-07-10 AT AT01955807T patent/ATE387222T1/de not_active IP Right Cessation
- 2001-07-10 JP JP2002511791A patent/JP2004512268A/ja active Pending
- 2001-07-10 AU AU2001277863A patent/AU2001277863A1/en not_active Abandoned
- 2001-07-10 WO PCT/US2001/021731 patent/WO2002005860A1/en active IP Right Grant
- 2001-07-10 DE DE60133010T patent/DE60133010T2/de not_active Expired - Lifetime
- 2001-07-10 CA CA2415295A patent/CA2415295C/en not_active Expired - Fee Related
- 2001-07-10 EP EP01955807A patent/EP1311300B1/de not_active Expired - Lifetime
- 2001-07-10 ES ES01955807T patent/ES2300345T3/es not_active Expired - Lifetime
- 2001-07-12 US US09/904,045 patent/US6838291B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE387222T1 (de) | 2008-03-15 |
JP2004512268A (ja) | 2004-04-22 |
CA2415295A1 (en) | 2002-01-24 |
EP1311300B1 (de) | 2008-02-27 |
US20020034730A1 (en) | 2002-03-21 |
WO2002005860A1 (en) | 2002-01-24 |
AU2001277863A1 (en) | 2002-01-30 |
ES2300345T3 (es) | 2008-06-16 |
CA2415295C (en) | 2010-02-16 |
EP1311300A4 (de) | 2004-11-03 |
EP1311300A1 (de) | 2003-05-21 |
DE60133010T2 (de) | 2009-03-19 |
US6838291B2 (en) | 2005-01-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE387222T1 (de) | Radioliganden- und bindungs-assay | |
JPS6445365A (en) | Fluorescent chelate, fluorescently labeled idiosyncratically bonded reagent, immunoassey and compound | |
TR200002015T2 (tr) | Protein tirosin kinaz inhibitörleri olarak bisiklik heteroaromatik bileşikler. | |
BR9710513B1 (pt) | composto, complexo de quelato e intermediário para preparação de compostos tetradentados macrocìclicos. | |
AR021533A1 (es) | Derivados de 2,5-diazabiciclo[2.2.1]heptano, su preparacion y su aplicacion en terapeutica | |
WO1999020756A3 (en) | Human toll homologues | |
ATE505208T1 (de) | Rezeptorbindende konjugate | |
AU3669199A (en) | Methods of identifying and using hla binding compounds as hla-agonists and antagonists | |
WO2002012224A3 (en) | Bicyclic compounds as h3 receptor ligands | |
WO2002030373A3 (de) | Neue verwendung von kurzkettigen aldehyden und formaldehyd abspaltenden verbindungen | |
FR2770517B1 (fr) | Laitier de cimentation d'un puits, notamment d'un puits petrolier | |
AR028648A1 (es) | Derivados de 1,4-diazabiciclo[3.2.2]nonano-fenilisoxazol, su preparacion y su aplicacion en terapéutica | |
SV1999000060A (es) | Procedimiento para la preparacion de (s,s)-bencil-2,8-diazabiciclo 4.3.0 nonano ref. 32965-sv | |
TR200001333T2 (tr) | Kiral amin oksazolinil ligandlara dayanan geçiş metali katalizlenmiş tepkimeler | |
HK1025521A1 (en) | Use of 15-keto-prostaglandin-e compounds as endothelin antagonists | |
TR199900762T2 (xx) | Stresle aktifle�tirilen protein kinazlar�n�n engellenme y�ntemi. | |
TR199800164T1 (xx) | Farmakolojide yararl� norbenzomorfan haz�rlanmas�. | |
WO2001082871A3 (en) | Method of using zinc isotope for therapy and diagnosis of colon cancer | |
WO1999005521A3 (de) | Konjugat zur unterscheidung von krankhaftem und gesundem gewebe | |
BR9812694A (pt) | Derivados de aminoalquilfenol e compostos relacionados | |
DE59712604D1 (de) | Mittel zur identifizierung und therapie metastasierender tumore | |
HU9602157D0 (en) | Cyclic neurokinin a antagonists | |
WO2003038441A3 (en) | Screening methods based on cited family proteins | |
WO2001071346A3 (en) | Binding compounds for cc chemokine receptor 5 and methods for identifying them | |
AR020785A1 (es) | Nuevos procedimientos quimicos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: MERCK SHARP & DOHME CORP., RAHWAY, N.J., US |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: MARKS & CLERK (LUXEMBOURG) LLP, LUXEMBOURG, LU |
|
R081 | Change of applicant/patentee |
Ref document number: 1311300 Country of ref document: EP Owner name: SCHERING CORPORATION, US Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., RAHWAY, US Effective date: 20121213 |
|
R082 | Change of representative |
Ref document number: 1311300 Country of ref document: EP Representative=s name: MARKS & CLERK (LUXEMBOURG) LLP, LU Effective date: 20121213 |