DE60118983D1 - Verfahren zur herstellung von nano- und mikro-teilchen - Google Patents

Verfahren zur herstellung von nano- und mikro-teilchen

Info

Publication number
DE60118983D1
DE60118983D1 DE60118983T DE60118983T DE60118983D1 DE 60118983 D1 DE60118983 D1 DE 60118983D1 DE 60118983 T DE60118983 T DE 60118983T DE 60118983 T DE60118983 T DE 60118983T DE 60118983 D1 DE60118983 D1 DE 60118983D1
Authority
DE
Germany
Prior art keywords
carbon dioxide
solubilizing
supercritical
micronic
conditions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60118983T
Other languages
English (en)
Other versions
DE60118983T2 (de
DE60118983T3 (de
Inventor
Ernesto Reverchon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micro & Nano Materials Sagl Lu
Original Assignee
Micro & Nano Materials Sagl Lu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4563123&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60118983(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Micro & Nano Materials Sagl Lu filed Critical Micro & Nano Materials Sagl Lu
Application granted granted Critical
Publication of DE60118983D1 publication Critical patent/DE60118983D1/de
Publication of DE60118983T2 publication Critical patent/DE60118983T2/de
Publication of DE60118983T3 publication Critical patent/DE60118983T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60118983.3T 2001-07-02 2001-09-27 Verfahren zur Herstellung von Nano- und Mikro-Teilchen Expired - Lifetime DE60118983T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH120901 2001-07-02
CH12092001 2001-07-02
EP01970064.0A EP1401563B2 (de) 2001-07-02 2001-09-27 Verfahren zur herstellung von nano- und mikro-teilchen
PCT/IB2001/001780 WO2003004142A1 (en) 2001-07-02 2001-09-27 Process for the production of micro and/or nano particles

Publications (3)

Publication Number Publication Date
DE60118983D1 true DE60118983D1 (de) 2006-05-24
DE60118983T2 DE60118983T2 (de) 2007-01-11
DE60118983T3 DE60118983T3 (de) 2016-07-07

Family

ID=4563123

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60118983.3T Expired - Lifetime DE60118983T3 (de) 2001-07-02 2001-09-27 Verfahren zur Herstellung von Nano- und Mikro-Teilchen

Country Status (8)

Country Link
US (1) US7276190B2 (de)
EP (1) EP1401563B2 (de)
AT (1) ATE323549T2 (de)
DE (1) DE60118983T3 (de)
DK (1) DK1401563T4 (de)
ES (1) ES2261469T5 (de)
PT (1) PT1401563E (de)
WO (1) WO2003004142A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767249B2 (en) * 2001-06-07 2010-08-03 Hewlett-Packard Development Company, L.P. Preparation of nanoparticles
WO2006035425A2 (en) * 2004-09-27 2006-04-06 Technion Research & Development Foundation Ltd. Spray method for producing semiconductor nanoparticles
WO2006062980A2 (en) * 2004-12-07 2006-06-15 Nektar Therapeutics Stable non-crystalline formulation comprising tiagabine
EP1904219A4 (de) 2005-07-15 2011-07-27 Map Pharmaceuticals Inc Teilchenbildungsverfahren
US20070023035A1 (en) * 2005-07-29 2007-02-01 Kane Kevin M Method for processing drugs
US20080223136A1 (en) * 2005-08-04 2008-09-18 Tokyo Electron Limited Minute structure inspection device, inspection method, and inspection program
WO2007028421A1 (en) * 2005-09-09 2007-03-15 Universita' Degli Studi Di Padova Process for the production of nano-particles
US20070128291A1 (en) * 2005-12-07 2007-06-07 Tokie Jeffrey H Method and Apparatus for Forming Chromonic Nanoparticles
WO2008058054A2 (en) * 2006-11-06 2008-05-15 Novartis Ag Method for making parenteral pharmaceutical compositions in a unit dose container
CN100444943C (zh) * 2007-02-14 2008-12-24 浙江大学 水力空化增强超临界辅助雾化制备微粒的系统及其方法
US9291139B2 (en) 2008-08-27 2016-03-22 Woodward, Inc. Dual action fuel injection nozzle
EP2181604A1 (de) 2008-11-04 2010-05-05 Feyecon Development & Implementation B.V. Dispersionsstrukturierungsmittel
ES2342140B1 (es) 2008-12-30 2011-05-17 Consejo Superior Investigacion Procedimiento para la obtencion de micro- o nanoparticulas solidas
WO2011159218A1 (en) * 2010-06-14 2011-12-22 Xspray Microparticles Ab Apparatus and method for the production of particles
DK3302431T3 (da) 2015-06-04 2020-11-30 Crititech Inc Taxanpartikler og anvendelse deraf
RU2737934C2 (ru) 2016-04-04 2020-12-07 Крититек, Инк. Способы лечения солидных опухолей
KR20200014279A (ko) 2017-06-09 2020-02-10 크리티테크, 인크. 항신생물 입자의 낭내 주사에 의한 상피낭종의 치료
SG10201913400QA (en) 2017-06-14 2020-03-30 Crititech Inc Methods for treating lung disorders
RU2020110399A (ru) 2017-10-03 2021-11-09 Крититек, Инк. Местная доставка противоопухолевых частиц в комбинации с системной доставкой иммунотерапевтических агентов для лечения рака

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348422A (en) * 1978-02-13 1982-09-07 Studiengesellschaft Kohle M.B.H. Process for the direct decaffeination of aqueous coffee extract solutions
DE3937287A1 (de) 1989-11-09 1991-05-16 Henkel Kgaa Verfahren und anlage zum abtrennen von fettsaeuremonoglycerid
US20020018815A1 (en) * 1992-03-06 2002-02-14 Sievers Robert E. Methods and apparatus for fine particle formation
GB9313642D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
SI9400079B (sl) * 1994-02-15 2003-02-28 Dr. Weidner Eckhard, Dipl. Ing. Postopek in naprava za pridobivanje in frakcioniranje majhnih delcev iz raztopin nasičenih s plinom
US5874029A (en) * 1996-10-09 1999-02-23 The University Of Kansas Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent
EP0885038B1 (de) * 1996-03-01 2011-06-15 The University Of Kansas Methoden und vorrichtungen zur teilchenausfallung und -beschichtung mit fast kritischen oder uberkritischen anti-losungsmitteln
US6221153B1 (en) * 1998-06-09 2001-04-24 Trevor Percival Castor Method for producing large crystals of complex molecules
SE9804000D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New composition of matter
GB9828204D0 (en) 1998-12-21 1999-02-17 Smithkline Beecham Plc Process
ES2170008B1 (es) 2000-08-25 2003-05-01 Soc Es Carburos Metalicos Sa Procedimiento para la precipitacion de particulas solidas finamente divididas.

Also Published As

Publication number Publication date
US20040178529A1 (en) 2004-09-16
EP1401563A1 (de) 2004-03-31
ES2261469T5 (es) 2015-12-22
DE60118983T2 (de) 2007-01-11
ATE323549T2 (de) 2006-05-15
DE60118983T3 (de) 2016-07-07
WO2003004142A1 (en) 2003-01-16
PT1401563E (pt) 2006-08-31
EP1401563B1 (de) 2006-04-19
ES2261469T3 (es) 2006-11-16
EP1401563B2 (de) 2015-09-16
US7276190B2 (en) 2007-10-02
DK1401563T3 (da) 2006-08-14
DK1401563T4 (en) 2016-01-11

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Legal Events

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8363 Opposition against the patent