DE60117280D1 - Nicht-menschliches transgenes tier, welches ca-ahr exprimiert - Google Patents
Nicht-menschliches transgenes tier, welches ca-ahr exprimiertInfo
- Publication number
- DE60117280D1 DE60117280D1 DE60117280T DE60117280T DE60117280D1 DE 60117280 D1 DE60117280 D1 DE 60117280D1 DE 60117280 T DE60117280 T DE 60117280T DE 60117280 T DE60117280 T DE 60117280T DE 60117280 D1 DE60117280 D1 DE 60117280D1
- Authority
- DE
- Germany
- Prior art keywords
- cancer
- ahr
- investigation
- study
- human animals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000009261 transgenic effect Effects 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 3
- 238000011835 investigation Methods 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract 1
- 208000009956 adenocarcinoma Diseases 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940000406 drug candidate Drugs 0.000 abstract 1
- 206010017758 gastric cancer Diseases 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 238000010874 in vitro model Methods 0.000 abstract 1
- 230000007246 mechanism Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000009456 molecular mechanism Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 201000011549 stomach cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Animal Husbandry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biodiversity & Conservation Biology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24354800P | 2000-10-26 | 2000-10-26 | |
US243548P | 2000-10-26 | ||
PCT/SE2001/002335 WO2002034928A1 (en) | 2000-10-26 | 2001-10-25 | Non-human transgenic animal expressing ca-ahr |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60117280D1 true DE60117280D1 (de) | 2006-04-20 |
DE60117280T2 DE60117280T2 (de) | 2006-11-02 |
Family
ID=22919182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60117280T Expired - Lifetime DE60117280T2 (de) | 2000-10-26 | 2001-10-25 | Nicht-menschliches transgenes tier, welches ca-ahr exprimiert |
Country Status (6)
Country | Link |
---|---|
US (1) | US7098376B2 (de) |
EP (1) | EP1328652B1 (de) |
AT (1) | ATE317907T1 (de) |
AU (1) | AU2001296198A1 (de) |
DE (1) | DE60117280T2 (de) |
WO (1) | WO2002034928A1 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1625395B1 (de) * | 2003-05-14 | 2009-09-16 | InDex Pharmaceuticals AB | Verfahren zur identifizierung von tff2 regulierenden agentien |
US10314810B2 (en) | 2010-07-27 | 2019-06-11 | Trustees Of Boston University | Aryl hydrocarbon receptor (AhR) modifiers as novel cancer therapeutics |
WO2016085876A1 (en) | 2014-11-25 | 2016-06-02 | The Broad Institute Inc. | Clonal haematopoiesis |
US11168369B2 (en) | 2014-11-25 | 2021-11-09 | The Brigham And Women's Hospital, Inc. | Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease |
CN110810323B (zh) * | 2019-04-23 | 2021-09-14 | 中国科学院脑科学与智能技术卓越创新中心 | 制备具有强迫仪式样行为的非人灵长类动物模型的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5378822A (en) * | 1993-04-08 | 1995-01-03 | Wisconsin Alumni Research | Nucleic acids encoding murine and human Ah receptors |
US5650283A (en) * | 1993-04-08 | 1997-07-22 | Northwestern University | Biological assay for detecting agonists to the Ah receptor |
US7105647B1 (en) | 1997-11-28 | 2006-09-12 | Wisconsin Alumni Research Foundation | cDNAs and proteins involved in hypoxia, circadian and orphan signal transduction pathways, and methods of use |
-
2001
- 2001-10-25 DE DE60117280T patent/DE60117280T2/de not_active Expired - Lifetime
- 2001-10-25 US US10/415,255 patent/US7098376B2/en not_active Expired - Fee Related
- 2001-10-25 WO PCT/SE2001/002335 patent/WO2002034928A1/en active IP Right Grant
- 2001-10-25 EP EP01977048A patent/EP1328652B1/de not_active Expired - Lifetime
- 2001-10-25 AU AU2001296198A patent/AU2001296198A1/en not_active Abandoned
- 2001-10-25 AT AT01977048T patent/ATE317907T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1328652B1 (de) | 2006-02-15 |
AU2001296198A1 (en) | 2002-05-06 |
ATE317907T1 (de) | 2006-03-15 |
US7098376B2 (en) | 2006-08-29 |
DE60117280T2 (de) | 2006-11-02 |
WO2002034928A1 (en) | 2002-05-02 |
US20040088743A1 (en) | 2004-05-06 |
EP1328652A1 (de) | 2003-07-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: INDEX THERAPEUTICALS AB, STOCKHOLM, SE |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: INDEX PHARMACEUTICALS AB, STOCKHOLM, SE |