DE60100539D1 - Tosylprolin-derivate als thymidylat-synthase inhibitoren - Google Patents

Tosylprolin-derivate als thymidylat-synthase inhibitoren

Info

Publication number
DE60100539D1
DE60100539D1 DE60100539T DE60100539T DE60100539D1 DE 60100539 D1 DE60100539 D1 DE 60100539D1 DE 60100539 T DE60100539 T DE 60100539T DE 60100539 T DE60100539 T DE 60100539T DE 60100539 D1 DE60100539 D1 DE 60100539D1
Authority
DE
Germany
Prior art keywords
tosylprolin
thymidylat
inhibitoren
synthase
derivate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60100539T
Other languages
English (en)
Other versions
DE60100539T2 (de
Inventor
A Erlanson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viracta Therapeutics Inc
Original Assignee
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunesis Pharmaceuticals Inc filed Critical Sunesis Pharmaceuticals Inc
Publication of DE60100539D1 publication Critical patent/DE60100539D1/de
Application granted granted Critical
Publication of DE60100539T2 publication Critical patent/DE60100539T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60100539T 2000-02-02 2001-02-02 Tosylprolin-derivate als thymidylat-synthase inhibitoren Expired - Fee Related DE60100539T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US496378 2000-02-02
US09/496,378 US6143776A (en) 2000-02-02 2000-02-02 Tosylproline analogs as thymidylate synthase inhibitors
PCT/US2001/003391 WO2001056987A1 (en) 2000-02-02 2001-02-02 Tosylproline analogs as thymidylate synthase inhibitors

Publications (2)

Publication Number Publication Date
DE60100539D1 true DE60100539D1 (en) 2003-09-04
DE60100539T2 DE60100539T2 (de) 2004-06-09

Family

ID=23972366

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60100539T Expired - Fee Related DE60100539T2 (de) 2000-02-02 2001-02-02 Tosylprolin-derivate als thymidylat-synthase inhibitoren

Country Status (8)

Country Link
US (1) US6143776A (de)
EP (1) EP1252141B1 (de)
JP (1) JP2003521535A (de)
AT (1) ATE246174T1 (de)
AU (2) AU3324201A (de)
CA (1) CA2398752A1 (de)
DE (1) DE60100539T2 (de)
WO (1) WO2001056987A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6589978B2 (en) * 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives
US7018642B2 (en) * 2001-04-27 2006-03-28 The Procter & Gamble Company Compounds, compositions, and methods for controlling biofilms
US8019550B2 (en) * 2002-07-24 2011-09-13 Keddem Bioscience Ltd. Drug discovery method
WO2010138955A2 (en) * 2009-05-29 2010-12-02 University Of Florida Research Foundation, Inc. Methods and compositions for treating neoplasia
ITMI20130085A1 (it) * 2013-01-22 2014-07-23 Gabriele Cruciani Nuove molecole per uso come agenti antitumorali
CA3098138A1 (en) * 2018-05-16 2019-11-21 Infex Therapeutics Limited Antibacterial compounds
MX2021013594A (es) 2019-05-06 2021-12-10 Janssen Sciences Ireland Unlimited Co Derivados de amida utiles en el tratamiento de la infeccion por vhb o de enfermedades inducidas por vhb.
WO2021242753A1 (en) * 2020-05-26 2021-12-02 The Regents Of The University Of Michigan Mitochondrial targeting compounds for the treatment of associated diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0031237B1 (de) * 1979-12-19 1984-10-17 National Research Development Corporation Chinazolinderivate, Verfahren zu ihrer Herstellung, sie enthaltende Zusammensetzungen und ihre Verwendung als Anti-Krebs-Mittel
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US4925939A (en) * 1989-01-05 1990-05-15 Sloan-Kettering Institute For Cancer Research 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives
US5958930A (en) * 1991-04-08 1999-09-28 Duquesne University Of The Holy Ghost Pyrrolo pyrimidine and furo pyrimidine derivatives
GB9205320D0 (en) * 1992-03-11 1992-04-22 Ici Plc Anti-tumour compounds
GB9205907D0 (en) * 1992-03-18 1992-04-29 Cancer Res Inst Royal Anti-cancer compounds
DK0927161T3 (da) * 1996-08-28 2003-02-17 Procter & Gamble Substitueret cyklisk amin-metalloproteaseinhibitorer
AU4722197A (en) * 1996-10-22 1998-05-15 Daiichi Pharmaceutical Co., Ltd. Novel remedies for infectious diseases
AR016133A1 (es) * 1997-07-31 2001-06-20 Wyeth Corp Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria

Also Published As

Publication number Publication date
JP2003521535A (ja) 2003-07-15
DE60100539T2 (de) 2004-06-09
WO2001056987A1 (en) 2001-08-09
EP1252141A1 (de) 2002-10-30
AU2001233242B2 (en) 2004-11-18
AU3324201A (en) 2001-08-14
US6143776A (en) 2000-11-07
EP1252141B1 (de) 2003-07-30
ATE246174T1 (de) 2003-08-15
CA2398752A1 (en) 2001-08-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee