DE60040801D1 - Antikörper gegen menschlichen toll-ähnlichen rezeptor-2 (tlr2) und seine verwendungen - Google Patents

Antikörper gegen menschlichen toll-ähnlichen rezeptor-2 (tlr2) und seine verwendungen

Info

Publication number
DE60040801D1
DE60040801D1 DE60040801T DE60040801T DE60040801D1 DE 60040801 D1 DE60040801 D1 DE 60040801D1 DE 60040801 T DE60040801 T DE 60040801T DE 60040801 T DE60040801 T DE 60040801T DE 60040801 D1 DE60040801 D1 DE 60040801D1
Authority
DE
Germany
Prior art keywords
tlr2
antibody
human toll
similar receptor
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60040801T
Other languages
English (en)
Inventor
Terje Espevik
Anders Sundan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leiv Eiriksson Nyskapning AS
Original Assignee
Leiv Eiriksson Nyskapning AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiv Eiriksson Nyskapning AS filed Critical Leiv Eiriksson Nyskapning AS
Application granted granted Critical
Publication of DE60040801D1 publication Critical patent/DE60040801D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60040801T 1999-11-18 2000-11-17 Antikörper gegen menschlichen toll-ähnlichen rezeptor-2 (tlr2) und seine verwendungen Expired - Lifetime DE60040801D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9927332.8A GB9927332D0 (en) 1999-11-18 1999-11-18 Novel antibody and uses thereof
PCT/GB2000/004382 WO2001036488A1 (en) 1999-11-18 2000-11-17 Antibody against the human toll-like receptor-2 (tlr2) and uses thereof

Publications (1)

Publication Number Publication Date
DE60040801D1 true DE60040801D1 (de) 2008-12-24

Family

ID=10864770

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60040801T Expired - Lifetime DE60040801D1 (de) 1999-11-18 2000-11-17 Antikörper gegen menschlichen toll-ähnlichen rezeptor-2 (tlr2) und seine verwendungen

Country Status (7)

Country Link
US (1) US7071310B1 (de)
EP (1) EP1232184B1 (de)
AU (1) AU1404701A (de)
DE (1) DE60040801D1 (de)
GB (1) GB9927332D0 (de)
NO (1) NO20022280L (de)
WO (1) WO2001036488A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
US7220723B2 (en) 2001-05-15 2007-05-22 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
US7304034B2 (en) 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
JP2005501917A (ja) * 2001-09-07 2005-01-20 ザ トラスティーズ オブ ボストン ユニバーシティ 免疫複合体関連疾患を処置するための方法および組成物
ATE394671T1 (de) * 2002-07-24 2008-05-15 Centre Nat Rech Scient Verfahren um biologische aktive verbindungen zu identifizieren, die anti-asthmatische und/oder anti-allergische eigenschaften haben
AU2003901325A0 (en) * 2003-03-21 2003-04-03 Stephen Locarnini Therapeutic, prophylactic and diagnostic agents
US7696169B2 (en) 2003-06-06 2010-04-13 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
WO2005019431A2 (en) * 2003-08-20 2005-03-03 University Of Massachusetts Selective inhibition of toll-like receptor-2
JP4792392B2 (ja) 2003-09-11 2011-10-12 コーナーストーン セラピューティクス インコーポレイテッド Ｈｍｇｂ１に対するモノクローナル抗体
EP1664118B1 (de) 2003-09-23 2011-05-25 Technische Universität München Tlr2-antagonistischer antikörper und dessen verwendung
EP1713935B1 (de) 2004-01-22 2011-10-05 University of Massachusetts Modulation einer hsv-infektion
CA2596079A1 (en) * 2005-01-31 2006-08-10 Vaxinnate Corporation Novel polypeptide ligands for toll-like receptor 2 (tlr2)
WO2008132516A1 (en) * 2007-04-26 2008-11-06 Opsona Therapeutics Limited Toll-like receptor binding epitope and compositions for binding thereto
AU2008267151B2 (en) 2007-06-28 2014-02-20 Neuramedy Co., Ltd. Composition and method for treatment of autoimmune disease
EP2215474A4 (de) 2007-07-16 2012-07-18 Avaxia Biologics Inc Antikörpertherapie zur modulation der funktion von darmrezeptoren
EP2725035A1 (de) 2007-10-02 2014-04-30 Avaxia Biologics, Inc. Antikörpertherapie zur Verwendung im Verdauungstrakt
WO2010033294A1 (en) 2008-09-22 2010-03-25 Cedars-Sinai Medical Center Short-form human md-2 as a negative regulator of toll-like receptor 4 signaling
US9512196B2 (en) 2008-09-22 2016-12-06 Cedars-Sinai Medical Center Short-form human MD-2 as a negative regulator of toll-like receptor 4 signaling
IE20090514A1 (en) 2009-07-06 2011-02-16 Opsona Therapeutics Ltd Humanised antibodies and uses therof
GB201205633D0 (en) 2012-03-30 2012-05-16 Opsona Therapeutics Ltd Toll-like receptor 2 binding epitope and binding members thereto
WO2015129858A1 (ja) 2014-02-28 2015-09-03 アステラス製薬株式会社 新規ヒトｔｌｒ２及びヒトｔｌｒ４に結合する二重特異的抗体
CN108196051B (zh) * 2018-04-04 2019-02-26 首都医科大学附属北京地坛医院 包含cd14检测试剂的梅毒检测试剂盒及该试剂在梅毒检测中的应用
CN111440240A (zh) * 2020-03-30 2020-07-24 中国人民解放军南部战区总医院 一种单克隆抗体及其制备方法和应用
CN111393530A (zh) * 2020-03-30 2020-07-10 中国人民解放军南部战区总医院 新人源tlr2胞外区段单克隆抗体及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69434812D1 (de) 1993-05-28 2006-09-14 Scripps Research Inst Methoden für inhibition der cd14-abhängigen zellaktivierung
DE69841514D1 (de) * 1997-05-07 2010-04-01 Schering Corp Menschliche Toll-Like-Rezeptorproteine, zugehörige Reagenzien und Verfahren

Also Published As

Publication number Publication date
NO20022280D0 (no) 2002-05-14
EP1232184A1 (de) 2002-08-21
EP1232184B1 (de) 2008-11-12
NO20022280L (no) 2002-07-08
WO2001036488A1 (en) 2001-05-25
AU1404701A (en) 2001-05-30
GB9927332D0 (en) 2000-01-12
US7071310B1 (en) 2006-07-04

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