DE60036224D1 - Screening-verfahren für auf neuronen wirkzamen verbindungen - Google Patents

Screening-verfahren für auf neuronen wirkzamen verbindungen

Info

Publication number
DE60036224D1
DE60036224D1 DE60036224T DE60036224T DE60036224D1 DE 60036224 D1 DE60036224 D1 DE 60036224D1 DE 60036224 T DE60036224 T DE 60036224T DE 60036224 T DE60036224 T DE 60036224T DE 60036224 D1 DE60036224 D1 DE 60036224D1
Authority
DE
Germany
Prior art keywords
neuronic
active compounds
screening procedure
screening
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60036224T
Other languages
English (en)
Other versions
DE60036224T2 (de
Inventor
Pascal Villa
Michel Delaage
Toni Williamson
Christopher Henderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trophos SA
Original Assignee
Trophos SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trophos SA filed Critical Trophos SA
Publication of DE60036224D1 publication Critical patent/DE60036224D1/de
Application granted granted Critical
Publication of DE60036224T2 publication Critical patent/DE60036224T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60036224T 1999-12-09 2000-12-07 Screening-verfahren für auf neuronen wirkzamen verbindungen Expired - Lifetime DE60036224T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99403092 1999-12-09
EP99403092A EP1107003A1 (de) 1999-12-09 1999-12-09 Verfahren zum Screening von Verbindungen die auf Neuronen wirken
PCT/EP2000/012340 WO2001042784A2 (en) 1999-12-09 2000-12-07 Methods for screening compounds active on neurons

Publications (2)

Publication Number Publication Date
DE60036224D1 true DE60036224D1 (de) 2007-10-11
DE60036224T2 DE60036224T2 (de) 2008-05-15

Family

ID=8242213

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60036224T Expired - Lifetime DE60036224T2 (de) 1999-12-09 2000-12-07 Screening-verfahren für auf neuronen wirkzamen verbindungen

Country Status (6)

Country Link
US (1) US6949354B2 (de)
EP (2) EP1107003A1 (de)
JP (1) JP4898047B2 (de)
CA (1) CA2390671C (de)
DE (1) DE60036224T2 (de)
WO (1) WO2001042784A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509190B2 (en) * 1997-11-12 2003-01-21 The Trustees Of Columbia University In The City Of New York DNA regulatory element for the expression of transgenes in neurons of the mouse forebrain
JP2006506970A (ja) 2002-07-12 2006-03-02 ユニバーシティ オブ ワシントン 神経細胞の延長されたインビトロ培養のための方法および系
ES2770067T3 (es) 2004-05-11 2020-06-30 Ncardia Ag Descubrimiento de fármacos basado en células diferenciadas in vitro
EP1955190B1 (de) 2005-11-10 2018-08-29 In Silico Biosciences, Inc. Verfahren und vorrichtung zur computermodellierung des menschlichen gehirns zur vorhersage von medikamenteneffekten
JP5371953B2 (ja) 2007-04-20 2013-12-18 アキュセラ インコーポレイテッド 眼の疾患及び障害を治療するスチレニル誘導体化合物
WO2009005794A2 (en) 2007-06-29 2009-01-08 Acucela, Inc. Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders
RU2014151622A (ru) 2007-10-05 2015-08-20 Акусела Инк. Композиции и способы лечения нейродегенеративных заболеваний
FR2940650B1 (fr) 2008-12-29 2017-01-27 Trophos Nouveaux derives d'oxime du 3,5-seco-4-nor-cholestane, compositions pharmaceutiques les renfermant,et procede de preparation
US8211695B2 (en) * 2010-03-31 2012-07-03 Taipei Medical University Isolated transgenic mammalian neural cell for detection of a sample containing a chemical substance damage to neurological system or selection of drugs for treating neurodegenerative disorders
CN104703598A (zh) 2012-01-20 2015-06-10 奥克塞拉有限公司 用于疾病治疗的取代的杂环化合物
EP2970099A4 (de) 2013-03-12 2016-12-21 Acucela Inc Substituierte 3-phenylpropylaminderivate zur behandlung von augenerkrankungen und -leiden
US20230139724A1 (en) * 2021-10-29 2023-05-04 CCLabs Pty Ltd System and method for testing effects of chemical compounds on cognitive function

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681711A (en) * 1995-03-27 1997-10-28 University Of California-Los Angeles Method for promoting apoptosis in mammalian neual cells
WO1996040982A1 (en) * 1995-06-07 1996-12-19 Athena Neurosciences, Inc. Therapeutic inhibition of phospholipase a2 in neurodegenerative disease
US5902732A (en) * 1995-10-04 1999-05-11 Cytoscan Sciences Llc Drug screening process measuring changes in cell volume
WO1998022608A2 (en) * 1996-11-18 1998-05-28 Mcgill University Post-mitotic neurons containing adenovirus vectors that modulate apoptosis and growth
DE69819524T2 (de) * 1997-08-25 2004-09-23 Mcgill University, Montreal Verwendung von shp-1 und shp-2 zum nachweis von verbindungen, die an neuronalem überleben beteiligt sind
US20020009747A1 (en) * 1997-08-25 2002-01-24 Freda Diane Miller Methods and reagents for identifying modulators of neuronal apoptosis
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells

Also Published As

Publication number Publication date
WO2001042784A3 (en) 2001-12-13
US6949354B2 (en) 2005-09-27
DE60036224T2 (de) 2008-05-15
EP1236046B1 (de) 2007-08-29
JP2003516139A (ja) 2003-05-13
WO2001042784A2 (en) 2001-06-14
EP1236046A2 (de) 2002-09-04
WO2001042784A9 (en) 2002-11-07
US20030077665A1 (en) 2003-04-24
CA2390671A1 (en) 2001-06-14
CA2390671C (en) 2011-05-03
EP1107003A1 (de) 2001-06-13
JP4898047B2 (ja) 2012-03-14

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Legal Events

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