DE60024257D1 - Modulatoren der methylierung zur kontrolle von bakterieller virulenz - Google Patents

Modulatoren der methylierung zur kontrolle von bakterieller virulenz

Info

Publication number
DE60024257D1
DE60024257D1 DE60024257T DE60024257T DE60024257D1 DE 60024257 D1 DE60024257 D1 DE 60024257D1 DE 60024257 T DE60024257 T DE 60024257T DE 60024257 T DE60024257 T DE 60024257T DE 60024257 D1 DE60024257 D1 DE 60024257D1
Authority
DE
Germany
Prior art keywords
methylation
modulators
control
bacterial virulence
virulence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60024257T
Other languages
English (en)
Other versions
DE60024257T2 (de
Inventor
Mingxu Xu
Qinghong Han
Yuying Tan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anticancer Inc
Original Assignee
Anticancer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anticancer Inc filed Critical Anticancer Inc
Publication of DE60024257D1 publication Critical patent/DE60024257D1/de
Application granted granted Critical
Publication of DE60024257T2 publication Critical patent/DE60024257T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Cookers (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE60024257T 1999-06-09 2000-06-09 Modulatoren der methylierung zur kontrolle von bakterieller virulenz Expired - Lifetime DE60024257T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13830799P 1999-06-09 1999-06-09
US138307P 1999-06-09
PCT/US2000/015865 WO2000074686A1 (en) 1999-06-09 2000-06-09 Modulators of methylation for control of bacterial virulence

Publications (2)

Publication Number Publication Date
DE60024257D1 true DE60024257D1 (de) 2005-12-29
DE60024257T2 DE60024257T2 (de) 2006-07-20

Family

ID=22481445

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60024257T Expired - Lifetime DE60024257T2 (de) 1999-06-09 2000-06-09 Modulatoren der methylierung zur kontrolle von bakterieller virulenz

Country Status (8)

Country Link
US (1) US6632430B2 (de)
EP (1) EP1183034B1 (de)
JP (1) JP2003501391A (de)
AT (1) ATE310524T1 (de)
AU (1) AU784794B2 (de)
CA (1) CA2375383C (de)
DE (1) DE60024257T2 (de)
WO (1) WO2000074686A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026155B2 (en) * 1999-02-02 2006-04-11 Regents Of The University Of California Method of reducing bacterial proliferation
WO2003057007A2 (en) * 2001-12-31 2003-07-17 Anticancer, Inc. System for monitoring bacterial tumor treatment
US7264819B2 (en) * 2003-06-23 2007-09-04 Anticancer, Inc. Lyase treatment for P. carinii
US9200251B1 (en) 2011-03-31 2015-12-01 David Gordon Bermudes Bacterial methionine analogue and methionine synthesis inhibitor anticancer, antiinfective and coronary heart disease protective microcins and methods of treatment therewith

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5455727A (en) 1977-10-07 1979-05-04 Sankyo Co Ltd Method for preventing growth of mold
US4381004A (en) 1981-01-15 1983-04-26 Biomedics, Inc. Extracorporeal system for treatment of infectious and parasitic diseases
US4507287A (en) 1983-06-20 1985-03-26 Dixon Glen J Preparation and method for the treatment of acne
US4996308A (en) * 1988-03-25 1991-02-26 Merrell Dow Pharmaceuticals Inc. Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group
ZA894534B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Novel neplanocin derivatives
HU204843B (en) * 1988-09-27 1992-02-28 Merrell Dow Pharma Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
US6001840A (en) 1990-03-06 1999-12-14 Southern Research Institute Methods of treatment of viral infections using carbocyclic deoxyguanosine analogs
US5872104A (en) * 1994-12-27 1999-02-16 Oridigm Corporation Combinations and methods for reducing antimicrobial resistance

Also Published As

Publication number Publication date
EP1183034A1 (de) 2002-03-06
WO2000074686A1 (en) 2000-12-14
US6632430B2 (en) 2003-10-14
JP2003501391A (ja) 2003-01-14
AU784794B2 (en) 2006-06-22
DE60024257T2 (de) 2006-07-20
ATE310524T1 (de) 2005-12-15
CA2375383C (en) 2008-07-29
US20030138414A1 (en) 2003-07-24
AU5476900A (en) 2000-12-28
CA2375383A1 (en) 2000-12-14
EP1183034B1 (de) 2005-11-23

Similar Documents

Publication Publication Date Title
NO20005224D0 (no) BTK inhibitorer og fremgangsmÕter for deres identifikasjon og anvendelse
DK1320531T3 (da) Bicyclo-pyrazoler, der er aktive som kinase inhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger, der indeholder disse
TR200103216T2 (tr) Pirimidinon bileşimleri
PA8564901A1 (es) Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo
HUP0201214A3 (en) Inhibitors of impdh enzyme, pharmaceutical compositions containing them and their use
IL139862A0 (en) Thiazolidine or pyrrolidine derivatives as dipeptidyl peptidase iv effectors and pharmaceutical compositions containing the same
DK1311269T3 (da) Fremgangsmåde til anvendelse af diketopiperaziner og sammensætning, som indeholder dem
MY135732A (en) 5,6-trimethylenepyrimidin - 4 - one compounds
DE60124759D1 (en) Dna methyl transferase inhibitoren
HUP0301577A3 (en) Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors, pharmaceutical compositions containing them and their use
HK1044545A1 (zh) 貝他分泌酶組合物及其方法
TR200100054T2 (tr) Paroksetin metansülfonat
HUP0200355A2 (en) 4-aminopyrrolopyrimidines as kinase inhibitors, pharmaceutical compositions containing them and their use
HUP0302337A3 (en) Pyrimidine-2,4,6-trione metalloproteinase inhibitors, pharmaceutical compositions containing them and their use
NO20042144L (no) Enzymatiske sykliseringanalser for homocystein og cystathionin
AR038207A1 (es) Composicion farmaceutica dispersable oralmente de agomelatina
NO20055830D0 (no) Proglitazpnsalter, sa som pioglitazonsulfat og farmasoytiske sammensetnnger og fremgangsmater ved bruk av de samme
NO984290L (no) Farmas°ytisk nyttige forbindelser
HUP0202938A3 (en) N-aryl-2-sulfonamidobenzamides as phosphate transport inhibitors and pharmaceutical compositions containing them
NO980178D0 (no) Cyklo-oksygenase-inhibitor og amidin-derivatsalter, fremgangsmåte for fremstilling derav, anvendelse derav som legemidler, og farmasöytiske blandinger inneholdende slike derivater
MXPA04004372A (es) Derivados heterociclicos de glicinamida y su uso medico.
NO20015659L (no) Purinderivater, fremstillingsmetode og farmasöytiske preparater inneholdende disse
DE60024257D1 (de) Modulatoren der methylierung zur kontrolle von bakterieller virulenz
NO20031396L (no) Derivater av tryptamin og analoge sammensetninger, og farmasoytiske formuleringer som inneholder disse
GB9916810D0 (en) Killing cells

Legal Events

Date Code Title Description
8364 No opposition during term of opposition