DE59712344D1 - Use of peptidic bradykinin antagonists for the preparation of medicaments - Google Patents

Use of peptidic bradykinin antagonists for the preparation of medicaments

Info

Publication number
DE59712344D1
DE59712344D1 DE59712344T DE59712344T DE59712344D1 DE 59712344 D1 DE59712344 D1 DE 59712344D1 DE 59712344 T DE59712344 T DE 59712344T DE 59712344 T DE59712344 T DE 59712344T DE 59712344 D1 DE59712344 D1 DE 59712344D1
Authority
DE
Germany
Prior art keywords
preparation
medicaments
bradykinin antagonists
peptidic bradykinin
liver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59712344T
Other languages
German (de)
Inventor
Gerhard Breipohl
Stephan Henke
Jochen Knolle
Klaus Wirth
Max Hropot
Martin Bickel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to DE59712344T priority Critical patent/DE59712344D1/en
Application granted granted Critical
Publication of DE59712344D1 publication Critical patent/DE59712344D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/043—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Use of bradykinin antagonists or their salts for the preparation of drugs to treat chronic fibrogenetic liver disease (liver cirrhosis and liver fibrosis) and acute liver disease, as well as the prevention of complications, is claimed.
DE59712344T 1996-03-27 1997-03-14 Use of peptidic bradykinin antagonists for the preparation of medicaments Expired - Lifetime DE59712344D1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE59712344T DE59712344D1 (en) 1996-03-27 1997-03-14 Use of peptidic bradykinin antagonists for the preparation of medicaments

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19612067A DE19612067A1 (en) 1996-03-27 1996-03-27 Use of bradykinin antagonists for the manufacture of medicaments for the treatment of chronic fibrogenetic liver diseases and acute liver diseases
DE59712344T DE59712344D1 (en) 1996-03-27 1997-03-14 Use of peptidic bradykinin antagonists for the preparation of medicaments

Publications (1)

Publication Number Publication Date
DE59712344D1 true DE59712344D1 (en) 2005-07-21

Family

ID=7789557

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19612067A Withdrawn DE19612067A1 (en) 1996-03-27 1996-03-27 Use of bradykinin antagonists for the manufacture of medicaments for the treatment of chronic fibrogenetic liver diseases and acute liver diseases
DE59712344T Expired - Lifetime DE59712344D1 (en) 1996-03-27 1997-03-14 Use of peptidic bradykinin antagonists for the preparation of medicaments

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19612067A Withdrawn DE19612067A1 (en) 1996-03-27 1996-03-27 Use of bradykinin antagonists for the manufacture of medicaments for the treatment of chronic fibrogenetic liver diseases and acute liver diseases

Country Status (24)

Country Link
US (1) US5863901A (en)
EP (1) EP0797997B1 (en)
JP (1) JP4185169B2 (en)
KR (1) KR100453394B1 (en)
CN (1) CN1164421A (en)
AT (1) ATE297749T1 (en)
AU (1) AU1651697A (en)
BR (1) BR9701455A (en)
CA (1) CA2200040A1 (en)
CZ (1) CZ90797A3 (en)
DE (2) DE19612067A1 (en)
DK (1) DK0797997T3 (en)
ES (1) ES2242973T3 (en)
HR (1) HRP970171A2 (en)
HU (1) HUP9700642A3 (en)
ID (1) ID16413A (en)
IL (1) IL120521A0 (en)
NO (1) NO971453L (en)
PL (1) PL319193A1 (en)
PT (1) PT797997E (en)
SI (1) SI0797997T1 (en)
SK (1) SK39297A3 (en)
TR (1) TR199700228A2 (en)
ZA (1) ZA972599B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1914236A1 (en) 2002-04-10 2008-04-23 Ortho-McNeil Pharmaceutical, Inc. Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
TWI407960B (en) 2007-03-23 2013-09-11 Jerini Ag Small molecule bradykinin b2 receptor modulators
US20110288114A1 (en) * 2008-06-20 2011-11-24 Kinemed, Inc. Compositions for the treatment of fibrotic diseases or conditions
SG11202004653TA (en) 2017-11-24 2020-06-29 Pharvaris Netherlands B V Novel bradykinin b2 receptor antagonists
AR118983A1 (en) 2019-05-23 2021-11-17 Pharvaris Gmbh CYCLIC BRADYKININ RECEPTOR ANTAGONISTS
AR118982A1 (en) 2019-05-23 2021-11-17 Pharvaris Gmbh CYCLIC BRADYKININ RECEPTOR ANTAGONISTS

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4374847A (en) * 1980-10-27 1983-02-22 Ciba-Geigy Corporation 1-Carboxyalkanoylindoline-2-carboxylic acids
US4693993A (en) * 1985-06-13 1987-09-15 Stewart John M Bradykinin antagonist peptides
US4923963A (en) * 1987-09-02 1990-05-08 Nova Technology Limited Partnership Bradykinin antagonist peptides
AU3428089A (en) * 1988-03-25 1989-10-16 The Administrators Of The Tulane Eductional Fund Therapeutic peptides
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action
DE4013270A1 (en) * 1990-04-26 1991-10-31 Hoechst Ag PEPTIDES WITH BRADYKININ ANTAGONISTIC EFFECT
DE3926822A1 (en) * 1989-08-14 1991-02-21 Hoechst Ag PEPTIDES WITH BRADYKININ ANTAGONISTIC EFFECT
EP0502987B1 (en) * 1989-12-08 1994-08-31 Trustees Of Boston University Acylated bradykinin antagonists and uses therefor
MX9100717A (en) * 1990-08-24 1992-04-01 Syntex Inc BRADIQUININE ANTAGONISTS
JPH06508116A (en) * 1991-04-01 1994-09-14 コルテク，インコーポレイテッド bradykinin antagonist
CA2106762C (en) * 1991-04-19 2000-10-10 Donald J. Kyle Bradykinin antagonist peptides
EP0618809B1 (en) * 1991-04-19 1998-08-19 Scios Nova Inc. Bradykinin type peptides
WO1993011789A1 (en) * 1991-12-12 1993-06-24 Scios Nova Inc. Modified position (7) bradykinin antagonist peptides
FR2686343B1 (en) * 1992-01-17 1994-03-11 Adir Cie NOVEL PSEUDOPEPTIDE DERIVATIVES WITH ANTAGONIST ACTIVITY OF BRADYKININE, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
TW258739B (en) * 1992-04-04 1995-10-01 Hoechst Ag
FR2692581B1 (en) * 1992-06-18 1994-08-19 Adir New peptide derivatives with bradykinin antagonist activity, their preparation process and the pharmaceutical compositions containing them.
AU5098593A (en) * 1992-09-11 1994-04-12 Lajos Gera Bradykinin antagonists containing aliphatic amino acids in the 5-position
US5521158A (en) * 1992-10-08 1996-05-28 Scios Nova Inc. Pseudopeptide bradykinin receptor antagonists
IL107400A0 (en) * 1992-11-10 1994-01-25 Cortech Inc Bradykinin antagonists
WO1994019372A1 (en) * 1993-02-17 1994-09-01 Scios Nova Inc. Cyclic bradykinin antagonist peptides
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
ES2148347T3 (en) * 1993-09-09 2000-10-16 Scios Inc NON-PEPTIDIC BRADIQUININE RECEPTOR ANTAGONISTS PSEUDO.
DE4345062A1 (en) * 1993-12-31 1995-07-13 Hoechst Ag Use of bradykinin antagonists for the manufacture of medicaments for the treatment of viral diseases
CA2184824A1 (en) * 1994-03-09 1995-09-14 Val S. Goodfellow Bradykinin antagonist peptides incorporating n-substituted glycines

Also Published As

Publication number Publication date
HUP9700642A3 (en) 1998-03-02
EP0797997B1 (en) 2005-06-15
JPH1017491A (en) 1998-01-20
SK39297A3 (en) 1997-10-08
KR970064622A (en) 1997-10-13
SI0797997T1 (en) 2005-10-31
NO971453L (en) 1997-09-29
HU9700642D0 (en) 1997-05-28
BR9701455A (en) 1998-08-18
EP0797997A3 (en) 2000-05-31
CZ90797A3 (en) 1997-10-15
HRP970171A2 (en) 1998-04-30
TR199700228A2 (en) 1997-10-21
EP0797997A2 (en) 1997-10-01
PT797997E (en) 2005-09-30
US5863901A (en) 1999-01-26
CA2200040A1 (en) 1997-09-27
ES2242973T3 (en) 2005-11-16
ZA972599B (en) 1997-09-29
KR100453394B1 (en) 2004-12-30
CN1164421A (en) 1997-11-12
NO971453D0 (en) 1997-03-26
JP4185169B2 (en) 2008-11-26
DE19612067A1 (en) 1997-10-02
MX9702292A (en) 1997-09-30
ATE297749T1 (en) 2005-07-15
DK0797997T3 (en) 2005-10-17
PL319193A1 (en) 1997-09-29
HUP9700642A2 (en) 1998-01-28
ID16413A (en) 1997-09-25
AU1651697A (en) 1997-10-02
IL120521A0 (en) 1997-07-13

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, 65929 FRANKFURT,

8364 No opposition during term of opposition