DE59707355D1 - Use of bi-specific and trispecific antibodies to induce tumor immunity - Google Patents

Use of bi-specific and trispecific antibodies to induce tumor immunity

Info

Publication number
DE59707355D1
DE59707355D1 DE59707355T DE59707355T DE59707355D1 DE 59707355 D1 DE59707355 D1 DE 59707355D1 DE 59707355 T DE59707355 T DE 59707355T DE 59707355 T DE59707355 T DE 59707355T DE 59707355 D1 DE59707355 D1 DE 59707355D1
Authority
DE
Germany
Prior art keywords
specific
tumor immunity
induce tumor
trispecific antibodies
trispecific
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59707355T
Other languages
German (de)
Inventor
Dr Lindhofer
Prof-Dr Kolb
Prof-Dr Thierfelder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helmholtz Zentrum Muenchen Deutsches Forschung De
Original Assignee
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH filed Critical Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt GmbH
Application granted granted Critical
Publication of DE59707355D1 publication Critical patent/DE59707355D1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE59707355T 1996-09-03 1997-09-02 Use of bi-specific and trispecific antibodies to induce tumor immunity Expired - Lifetime DE59707355D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19635743 1996-09-03
DE19648976 1996-11-26
DE19710497A DE19710497C2 (en) 1996-09-03 1997-03-13 Use bi- and trispecific antibodies to induce tumor immunity

Publications (1)

Publication Number Publication Date
DE59707355D1 true DE59707355D1 (en) 2002-07-04

Family

ID=26028995

Family Applications (3)

Application Number Title Priority Date Filing Date
DE19710497A Expired - Fee Related DE19710497C2 (en) 1996-09-03 1997-03-13 Use bi- and trispecific antibodies to induce tumor immunity
DE59707355T Expired - Lifetime DE59707355D1 (en) 1996-09-03 1997-09-02 Use of bi-specific and trispecific antibodies to induce tumor immunity
DE122009000067C Pending DE122009000067I1 (en) 1996-09-03 1997-09-02 Use of bi- and trispecific antibodies to induce tumor immunity

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19710497A Expired - Fee Related DE19710497C2 (en) 1996-09-03 1997-03-13 Use bi- and trispecific antibodies to induce tumor immunity

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE122009000067C Pending DE122009000067I1 (en) 1996-09-03 1997-09-02 Use of bi- and trispecific antibodies to induce tumor immunity

Country Status (2)

Country Link
DE (3) DE19710497C2 (en)
NL (1) NL300420I1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018435A1 (en) * 1998-09-25 2000-04-06 Horst Lindhofer Time-staggered utilization of tumor cells in combination with intact antibodies for immunization
DE10043437A1 (en) 2000-09-04 2002-03-28 Horst Lindhofer Use of trifunctional bispecific and trispecific antibodies for the treatment of malignant ascites
DE10261223A1 (en) * 2002-12-20 2004-07-08 MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH Increasing the immune response through substances that influence the function of natural killer cells
DE102006006879A1 (en) * 2006-02-15 2007-08-23 Sascha Struffi Flat armpit sweat absorber for placing under an armpit comprises adhesive surfaces arranged on its upper side
EP1820513A1 (en) 2006-02-15 2007-08-22 Trion Pharma Gmbh Destruction of tumor cells expressing low to medium levels of tumor associated target antigens by trifunctional bispecific antibodies

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4419399C1 (en) * 1994-06-03 1995-03-09 Gsf Forschungszentrum Umwelt Process for the preparation of heterologous bispecific antibodies

Also Published As

Publication number Publication date
DE19710497C2 (en) 1998-07-09
DE122009000067I1 (en) 2010-01-21
NL300420I1 (en) 2010-01-04
DE19710497A1 (en) 1998-03-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNG, DE

V448 Application of spc

Free format text: PRODUCT NAME: MONOKLONARER RATTE-MAUS-HYBRIDANTIKOERPER (IGG2) IN ALLEN DEM SCHUTZ DES GRUNDPATENTS ZUGRUNDE LIEGENDEN FORMEN; REGISTRATION NO/DATE: EU/1/09/512/001, EU/1/09/512/002; 20090420

Spc suppl protection certif: 12 2009 000 067

Filing date: 20091020