DE574101C - Process for the production of novel lipoid preparations - Google Patents
Process for the production of novel lipoid preparationsInfo
- Publication number
- DE574101C DE574101C DE1930574101D DE574101DD DE574101C DE 574101 C DE574101 C DE 574101C DE 1930574101 D DE1930574101 D DE 1930574101D DE 574101D D DE574101D D DE 574101DD DE 574101 C DE574101 C DE 574101C
- Authority
- DE
- Germany
- Prior art keywords
- phosphatides
- lipoid
- preparations
- novel
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Fats And Perfumes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung neuartiger Lipoidpräparate Die aus dem Zentralnervensystem gewonnenen Phosphatide bzw. phosphatidhaltigen Lipoide weisen den Nachteil großer Empfindlichkeit gegen Feuchtigkeit, Luft und Licht auf und sind auch wegen ihrer strengen, wachsartigen Konsistenz sehr schlecht dosier-und verarbeitbar.Process for the production of novel lipoid preparations from the central nervous system obtained phosphatides or phosphatide-containing lipoids have the disadvantage of large Sensitivity to moisture, air and light and are also due to them strict, waxy consistency, very difficult to dose and process.
Es wurde nun gefunden, daß alle diese Mängel behoben werden können, wenn. man die genannten Stoffe auf trockene Getreidekeime aufbringt.It has now been found that all of these deficiencies can be remedied, if. the substances mentioned are applied to dry grain germs.
Man stellt die Produkte zweckmäßig in der Weise her, daß man die Phosphatide bzw. Lipoide in einem Lösungsmittel (Alkohol, Wasser u. dgl.) löst oder aufschwemmt bzw. erweicht, die Keime innig damit verrührt und schließlich das Lösungsmittel bei niedriger Temperatur in geeigneter Weise, z. B. durch Verdampfen im Vakuum, entfernt. Bildete öl das Lösungsmittel, so entfernt man dieses zunächst z. B. mit Aceton und trocknet alsdann. Man gelangt durch das Verfahren noch bei einem Gehalt von etwa 6o °1o Lipoide zu pulverförmigen bis kleinkörnigen Produkten. Es eignet sich in gleicher Weise für Phosphatide anderer Herkunft.The products are expediently prepared in such a way that the phosphatides or lipoids are dissolved or suspended or softened in a solvent (alcohol, water, etc.), the germs are intimately mixed with them and finally the solvent is suitably used at a low temperature Way, e.g. B. by evaporation in vacuo, removed. If oil formed the solvent, this is first removed z. B. with acetone and then dries. The process leads to powdery to fine-grained products at a content of about 60 ° 10 lipids. It is equally suitable for phosphatides of other origins.
Der zur Verwendung gelangende Träger wird, wenn nötig, vorher gemahlen; besonders gefördert wird der Zweck des Verfahrens, wenn die Getreidekeime vor ihrer Verwendung mit Wasser oder einem organischen Lösungsmittel - extrahiert werden.The carrier used is, if necessary, ground beforehand; The purpose of the procedure is particularly encouraged when the grain germs are in front of them Use with water or an organic solvent - be extracted.
Das vorliegende Verfahren gestattet erstmals Phosphatide und phosphatidhaltige Lipoide in hoher Konzentration (y5 bzw. 5o °f,) als feinkörnige bzw. pulverförmige Produkte-zu erhalten, welche sich trotz ihrer feinen Verteilung.und trotz der leichten Veränderlichkeit der Phosphatide, insbesondere der Lipoide des Zentralnervensystems, als haltbar erwiesen haben. Beispiel 5oo g Gesamtlipoide aus Hirn werden mit 4oo g. Alkohol in der Wärme verflüssigt und alsdann mit 5oo g Gerstenkeimen, welche vorher entstaubt, gemahlen und mit Alkohol extrahiert wurden, längere Zeit intensiv durchgeknetet. Schließlich destilliert man den Alkohol im Vakuum ab. Man gewinnt auf diese Weise z kg eines 5o °J, Lipoide enthaltenden Produkts.The present process allows for the first time phosphatides and those containing phosphatides Lipoids in high concentration (y5 or 50 ° f,) as fine-grained or powdery Products-to obtain which, despite their fine distribution. And despite the light Variability of the phosphatides, especially the lipoids of the central nervous system, have proven to be durable. Example 500 g of total lipids from brain are combined with 400 G. Alcohol liquefied in the heat and then with 500 g of barley germs, which dusted, ground and extracted with alcohol beforehand, intensively for a long time kneaded. Finally, the alcohol is distilled off in vacuo. One wins in this way z kg of a product containing 50 ° J, lipoids.
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE574101T | 1930-10-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE574101C true DE574101C (en) | 1933-04-08 |
Family
ID=6569426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1930574101D Expired DE574101C (en) | 1930-10-10 | 1930-10-10 | Process for the production of novel lipoid preparations |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE574101C (en) |
-
1930
- 1930-10-10 DE DE1930574101D patent/DE574101C/en not_active Expired
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